| Positioning of Esketamine Treatment in the Real-world Management of DepressionNCT06103760 · Royal North Shore Hospital | Recruiting | Phase 4 | 1 |
| Esketamine Versus Crisis Response Planning Versus Optimized Treatment as Usual for Suicide Prevention: A Pragmatic Controlled Trial in Two Brazilian CitiesNCT07120477 · University of Sao Paulo | Recruiting | Phase 4 | 1 |
| Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm RepairNCT04894864 · University of Crete | Recruiting | Phase 4 | 1 |
| Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant DepressionNCT06278779 · The George Institute | Recruiting | Phase 4 | 7 |
| Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma PatientsNCT06903819 · Texas Tech University Health Sciences Center | Recruiting | Phase 4 | 2 |
| Esketamine With or Without Integration Therapy for Treatment-Resistant DepressionNCT07369102 · University of Puerto Rico | Recruiting | Phase 4 | 2 |
| Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With DepressionNCT05450432 · Massachusetts General Hospital | Recruiting | Phase 4 | 1 |
| Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General AnesthesiaNCT06853431 · Second Affiliated Hospital of Wenzhou Medical University | Recruiting | Phase 4 | 2 |
| Neural Circuit Effects of Ketamine in DepressionNCT06213324 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 4 | 1 |
| Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECTNCT05655754 · Medical University of Vienna | Recruiting | Phase 4 | 1 |
| Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.NCT06774274 · Universidad de Antioquia | Recruiting | Phase 4 | 1 |
| The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSDNCT06414356 · Margaux M. Salas, PhD | Recruiting | Phase 4 | 1 |
| ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant DepressionNCT03272698 · University of Saskatchewan | Recruiting | Phase 4 | 1 |
| IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric EDNCT05934669 · University of Oklahoma | Recruiting | Phase 4 | 1 |
| InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpressionNCT06781697 · Sunnybrook Health Sciences Centre | Recruiting | Phase 3 | 1 |
| PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence StudyNCT06713616 · Yale University | Recruiting | Phase 3 | 8 |
| A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive DisorderNCT07227454 · Janssen Research & Development, LLC | Recruiting | Phase 3 | 35 |
| A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant DepressionNCT07716098 · Janssen Research & Development, LLC | Recruiting | Phase 3 | 4 |
| Ketamine Treatment of Youth Suicide AttemptersNCT04763343 · Tatiana Falcone, MD | Recruiting | Phase 3 | 1 |
| Understanding and Treating Suicidal Ideation With KetamineNCT06891300 · The Royal's Institute of Mental Health Research | Recruiting | Phase 2 / Phase 3 | 1 |
| Ketamine Augmentation of ECT in Treatment-Resistant DepressionNCT07088380 · Università Vita-Salute San Raffaele | Recruiting | Phase 3 | 1 |
| Nebulized Ketamine for the Treatment of Major Depressive DisorderNCT06752759 · Theresa Jacob, PhD, MPH | Recruiting | Phase 3 | 1 |
| Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureNCT05603104 · Dr. Inge Winter | Recruiting | Phase 3 | 1 |
| The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.NCT05973851 · Dr. Inge Winter | Recruiting | Phase 3 | 12 |
| Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression PatientsNCT06508710 · Assistance Publique - Hôpitaux de Paris | Recruiting | Phase 3 | 4 |
| Ketamine & Crisis Response Plan for Suicidal Ideation in the EDNCT05696691 · The University of Texas Health Science Center at San Antonio | Recruiting | Phase 2 / Phase 3 | 1 |
| Neurobiology of SuicideNCT02543983 · National Institute of Mental Health (NIMH) | Recruiting | Phase 2 | 1 |
| Pilot Study of RR-HNK in OCDNCT06575075 · Carolyn Rodriguez | Recruiting | Phase 1 / Phase 2 | 1 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)NCT07569198 · Joshua Rosenblat | Recruiting | Phase 2 | 1 |
| Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionNCT06511908 · National Institute of Mental Health (NIMH) | Recruiting | Phase 2 | 1 |
| Ketamine for Combined Depression and Alcohol Use DisorderNCT06090422 · University Hospital of North Norway | Recruiting | Phase 1 / Phase 2 | 1 |
| Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit PatientsNCT07639359 · Hospital Italiano de Buenos Aires | Recruiting | Phase 2 | 2 |
| The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsNCT05786066 · Yale University | Recruiting | Phase 2 | 1 |
| Ketamine Alcohol (in Treatment-Resistant Depression)NCT02122562 · Mark Niciu | Recruiting | Phase 2 | 1 |
| Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSDNCT06608277 · Northwestern University | Recruiting | Phase 2 | 3 |
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)NCT05940324 · Stanford University | Recruiting | Phase 2 | 1 |
| Ketamine for Opioid Use DisorderNCT06943859 · University of Maryland, Baltimore | Recruiting | Phase 2 | 1 |
| Imaging Depression in Parkinson's DiseaseNCT06402955 · Yale University | Recruiting | Phase 2 | 1 |
| A Study to Evaluate the Efficacy, Safety, and Pharmacokinetic Characteristics of (R)-Ketamine Hydrochloride Nasal Spray in Patients With Depression and Acute Suicidal Ideation or BehaviorNCT07193901 · Sichuan Purity Pharmaceutical Technology Co., Ltd. | Recruiting | Phase 2 | 8 |
| Ayahuasca, Esketamine and PTSDNCT07317206 · University of Sao Paulo | Recruiting | Phase 2 | 1 |
| Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid DepressionNCT06419439 · VA Office of Research and Development | Recruiting | Phase 2 | 1 |
| i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical TrialNCT06480500 · University Health Network, Toronto | Recruiting | Phase 2 | 1 |
| Ketamine and Neurofeedback as Combined Therapeutic Interventions to Target Glutamatergic Neurotransmission in Alcohol Use DisorderNCT06969937 · Dr. med. Marcus Herdener | Recruiting | Phase 2 | 1 |
| Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator TrialNCT06405607 · University of Iowa | Recruiting | Phase 2 | 1 |
| Pragmatic Trial of Psilocybin Therapy in Palliative CareNCT05403086 · Charles S. Grob, M.D. | Recruiting | Phase 2 | 5 |
| Intravenous Ketamine for Treatment-Resistant DepressionNCT06668571 · Mayo Clinic | Recruiting | Phase 2 | 1 |
| A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With DepressionNCT06597695 · Juliana Zambrano, MD, MPH | Recruiting | Phase 1 / Phase 2 | 1 |
| Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of DepressionNCT06559826 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 2 | 1 |
| Enhancing Week-long Psychological Treatment for PTSD With KetamineNCT05737693 · Yale University | Recruiting | Phase 2 | 2 |
| Pharmacologic Treatment Augmentation in Chronic DepressionNCT06410599 · University Hospital Tuebingen | Recruiting | Phase 2 | 2 |
| Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderNCT03065335 · National Institute of Mental Health (NIMH) | Recruiting | Phase 1 | 1 |
| Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant DepressionNCT06480201 · Texas A&M University | Recruiting | Phase 1 | 2 |
| Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionNCT03973268 · National Institute of Mental Health (NIMH) | Recruiting | Phase 1 | 1 |
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine ResponseNCT05915013 · Yale University | Recruiting | Phase 1 | 1 |
| HNC: Human Neural Circuits Electrophysiology During CognitionNCT05962424 · Stanford University | Recruiting | Phase 1 | 1 |
| Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency DepartmentNCT06085937 · Lindsay Maguire, MD | Recruiting | Phase 1 | 2 |
| Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of KetamineNCT06788249 · University of Pennsylvania | Recruiting | Early Phase 1 | 1 |
| Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With KetamineNCT05327699 · Emory University | Recruiting | Early Phase 1 | 1 |
| Personalized DBS Targeting for Treating DepressionNCT06784388 · Second Affiliated Hospital, Zhejiang University, School of Medicine | Recruiting | Early Phase 1 | 1 |
| Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic StudyNCT07247968 · Min Su | Recruiting | Early Phase 1 | 2 |
| Cognitive Training as an Adjunct to Ketamine in Real-world ClinicsNCT06526078 · University of Pittsburgh | Recruiting | Not applicable | 3 |
| The OBSERVE ProtocolNCT06725277 · Yale University | Recruiting | N/A | 8 |
| Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant DepressionNCT07563868 · Massachusetts General Hospital | Recruiting | Not applicable | 2 |
| Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD ClientsNCT07706478 · Senz | Recruiting | N/A | 1 |
| ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1NCT07528014 · Salma Health, Inc. | Recruiting | N/A | 2 |
| Belief Updating in Treatment Resistant DepressionNCT05577247 · Assistance Publique - Hôpitaux de Paris | Recruiting | N/A | 1 |
| Retrospective Analyses of the Greenbrook Database Evaluating Mental Health TreatmentsNCT06997549 · Neuronetics | Recruiting | N/A | 1 |
| Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant DepressionNCT07146503 · Riccardo Guglielmo | Recruiting | N/A | 5 |
| ACT_for Alcohol Use Disorder and DepressionNCT06620276 · Centre hospitalier de l'Université de Montréal (CHUM) | Recruiting | Not applicable | 1 |
| University of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · Mark Niciu | Recruiting | N/A | 1 |
| Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant DepressionNCT07422519 · Hospital Universitari Vall d'Hebron Research Institute | Recruiting | Not applicable | 1 |
| At-Home tDCS as Maintenance TherapyNCT07269964 · Technical University of Munich | Recruiting | Not applicable | 2 |
| Ketamine in OCD: Efficacy and Effects on Stress and CognitionNCT05577585 · Medical University of Vienna | Recruiting | Not applicable | 1 |
| Metabolic Profiling of Esketamine Treatment in Depressive DisorderNCT07002684 · University of Zagreb | Recruiting | N/A | 1 |
| Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-LifeNCT06824532 · Albany Research Institute, Inc. | Recruiting | N/A | 1 |
| Ketamine Enhances Analgesia and Mood in Chronic Pain PatientsNCT05985811 · Salem Anaesthesia Pain Clinic | Recruiting | N/A | 1 |
| Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot StudyNCT06732089 · Unity Health Toronto | Recruiting | N/A | 1 |
| Dexmedetomidine and Ketamine in VATS SurgeryNCT03596424 · Ciusss de L'Est de l'Île de Montréal | Recruiting | Not applicable | 1 |
| Ketamine Treatment Plans for Chronic ConditionsNCT06038409 · RIVER Foundation | Recruiting | N/A | 1 |
| RIVER At Home Ketamine ProtocolsNCT06070766 · RIVER Foundation | Recruiting | N/A | 2 |
| Study of the Neural Circuits Underlying the Negative Emotional Bias of Depressive Disorders and Their Response to KetamineNCT06630065 · Centre Hospitalier St Anne | Recruiting | Not applicable | 1 |
| IV Ketamine vs. IN Esketamine for MDD TRDNCT06488586 · Gustavo Vazquez | Recruiting | N/A | 1 |
| Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral ReconstructionNCT07753772 · Peking University First Hospital | Not yet recruiting | Phase 4 | 1 |
| A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant DepressionNCT07053345 · Janssen Korea, Ltd., Korea | Completed | Phase 4 | 6 |
| Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal ThoughtsNCT07139106 · New York State Psychiatric Institute | Not yet recruiting | Phase 4 | 1 |
| Biomarker-Guided Antidepressant SelectionNCT07680140 · Weill Medical College of Cornell University | Not yet recruiting | Phase 4 | 1 |
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum DepressionNCT07639099 · Peking University First Hospital | Not yet recruiting | Phase 4 | 1 |
| IM Ketamine vs Midazolam for Suicidal ER PatientsNCT04640636 · New York State Psychiatric Institute | Suspended | Phase 4 | 1 |
| Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)NCT04814381 · University Hospital, Clermont-Ferrand | Completed | Phase 4 | 14 |
| The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative DepressionNCT07179913 · The First Hospital of Jilin University | Active, not recruiting | Phase 4 | 1 |
| Postpartum Perineal Pain After Obstetric Anal Sphincter InjuriesNCT03470675 · Northwestern University | Completed | Phase 4 | 1 |
| Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for DepressionNCT05615948 · Theresa Jacob, PhD, MPH | Completed | Phase 4 | 1 |
| Ketamine + Cognitive Training for Suicidality in the Medical SettingNCT04578938 · Rebecca Price | Active, not recruiting | Phase 4 | 1 |
| Anhedonia, Development, and Emotions: Phenotyping and TherapeuticsNCT05487885 · Erika Forbes | Completed | Phase 4 | 1 |
| Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt InsertionNCT06060210 · Benha University | Completed | Phase 4 | 1 |
| Comparative Effectiveness of ECT vs. KETAMINE Over the LifespanNCT06034821 · Brigham and Women's Hospital | Enrolling by invitation | Phase 4 | 10 |
| Propofol-Enhanced Assessment of Ketamine for Chronic Pain and DepressionNCT06317636 · Stanford University | Active, not recruiting | Phase 4 | 1 |
| A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray TreatmentNCT04829318 · Janssen-Cilag Ltd. | Completed | Phase 4 | 59 |
| Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant DepressionNCT05045378 · Taipei Veterans General Hospital, Taiwan | Completed | Phase 4 | 1 |
| Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot StudyNCT05950711 · Ohio State University | Active, not recruiting | Phase 4 | 1 |
| Ketamine for Postherpetic Neuralgia With DepressionNCT06968624 · Huazhong University of Science and Technology | Not yet recruiting | Phase 4 | — |
| Ketamine-assisted Therapy for Advanced GI CancerNCT06077487 · Brian Anderson, MD | Terminated | Phase 4 | 1 |
| A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant DepressionNCT04599855 · Janssen Research & Development, LLC | Completed | Phase 4 | 54 |
| The Impact of Perioperative Ketamine Infusion on Surgical RecoveryNCT04625283 · Vanderbilt University Medical Center | Completed | Phase 4 | 1 |
| Different Doses of Dexmedetomidine Combined With Esketamine in Women Undergoing Cesarean DeliveryNCT06613243 · Peking University First Hospital | Completed | Phase 4 | 1 |
| Effect of Low-dose Esketamine on Maternal Depression at 3 Years After ChildbirthNCT05698394 · Peking University First Hospital | Active, not recruiting | Phase 4 | 4 |
| Effects of Epidural Labor Analgesia With Esketamine on the Incidence of Postpartum Depression in ParturientsNCT05826327 · Women's Hospital School Of Medicine Zhejiang University | Unknown status | Phase 4 | 1 |
| Ketamine + Cognitive Training for Suicidality in the Medical Setting: PilotNCT04154150 · Rebecca Price | Terminated | Phase 4 | 1 |
| Effect of Esketamine on Postoperative Depression、Gut Microbiota、Bispectral Index Data of Depression Patients Undergoing Breast Cancer Operation (ESPOD-BI)NCT04303325 · China Medical University, China | Unknown status | Phase 4 | 1 |
| A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health | Completed | Phase 4 | 11 |
| Effectiveness of Ketamine Treatment for Three Consecutive Days in DepressionNCT05026203 · Mahidol University | Completed | Phase 4 | 1 |
| Safety and Efficacy Evaluation of S (+) - Ketamine in ChildrenNCT04834427 · Chinese PLA General Hospital | Unknown status | Phase 4 | 1 |
| VA Aripiprazole vs Esketamine for Treatment Resistant DepressionNCT05554627 · VA Office of Research and Development | Withdrawn | Phase 4 | 26 |
| Ketamine Treatment Effects on Synaptic Plasticity in DepressionNCT04091971 · New York State Psychiatric Institute | Completed | Phase 4 | 1 |
| Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac SurgeryNCT03861988 · Stanford University | Completed | Phase 4 | 1 |
| Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the EDNCT05422001 · University of Aarhus | Terminated | Phase 4 | 1 |
| Clinical Study of Oral Midazolam Combined With Esketamine Administered Intranasally for Pediatric Preoperative SedationNCT05925283 · Second Affiliated Hospital of Wenzhou Medical University | Unknown status | Phase 4 | 1 |
| Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department PatientsNCT03043430 · Brooke Army Medical Center | Terminated | Phase 4 | 1 |
| Ketamine for Acute Pain Management After TraumaNCT04129086 · The University of Texas Health Science Center, Houston | Completed | Phase 4 | 1 |
| The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel DiseaseNCT05506787 · Jinling Hospital, China | Completed | Phase 4 | 1 |
| Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in DepressionNCT01881763 · Northwell Health | Completed | Phase 4 | 1 |
| Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve GastrectomyNCT04260659 · Medical University of Warsaw | Completed | Phase 4 | 1 |
| Ketamine for Older Adults PilotNCT04504175 · Washington University School of Medicine | Completed | Phase 4 | 5 |
| Preoperative Ketamine and Perioperative DepressionNCT04220125 · Northwestern University | Withdrawn | Phase 4 | — |
| An EEG Study of Intravenous Ketamine for Major Depression DisorderNCT05506462 · Ehave Inc. | Unknown status | Phase 4 | — |
| Ketamine Versus Fentanyl for Surgical AbortionsNCT04871425 · University of Washington | Completed | Phase 4 | 1 |
| The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.NCT03156504 · Mayo Clinic | Completed | Phase 4 | 4 |
| Effects of Esketamine on Postpartum DepressionNCT05229913 · Qinghai University | Unknown status | Phase 4 | — |
| Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal DepressionNCT03336541 · Peking University First Hospital | Completed | Phase 4 | 1 |
| Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive TherapyNCT02579642 · University of Alberta | Completed | Phase 4 | 2 |
| Intra-nasal vs. Intra-venous Ketamine AdministrationNCT02644629 · Shalvata Mental Health Center | Completed | Phase 4 | 1 |
| Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency DepartmentNCT04266288 · MercyOne Des Moines Medical Center | Completed | Phase 4 | 1 |
| A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)NCT03149991 · Massachusetts General Hospital | Completed | Phase 4 | 6 |
| Ketamine Infusion for Adolescent Depression and AnxietyNCT02579928 · Yale University | Completed | Phase 4 | 2 |
| Intranasal Sedation With Dexmedetomidine and Ketamine in Pediatric Dentistry (NASO II)NCT03290625 · Universidade Federal de Goias | Completed | Phase 4 | 1 |
| The Effect of Ketamine on the Length of Hospital Stay of Patients Hospitalized With Suicidal Ideation.NCT02997722 · Allen Richert | Terminated | Phase 4 | 1 |
| Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)NCT04352621 · University of Cincinnati | Unknown status | Phase 4 | — |
| Ketamine in the Treatment of Suicidal DepressionNCT01700829 · New York State Psychiatric Institute | Completed | Phase 4 | 1 |
| Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant DepressionNCT04234776 · University of Sao Paulo | Unknown status | Phase 4 | 1 |
| Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or KetamineNCT03788889 · Santa Barbara Cottage Hospital | Withdrawn | Phase 4 | — |
| Research Study for Major Depressive Disorder: Investigation of Glutamate MedicationsNCT00419003 · Baylor College of Medicine | Completed | Phase 4 | 1 |
| Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive TherapyNCT03829124 · Chang Gung Memorial Hospital | Unknown status | Phase 4 | — |
| Ketamine for Depression: An MRI StudyNCT02544607 · Massachusetts General Hospital | Completed | Phase 4 | 1 |
| RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn PainNCT03305055 · Johns Hopkins University | Terminated | Phase 4 | 1 |
| Ketamine Co-induction for Patients With Major Depressive DisorderNCT03666494 · University of Saskatchewan | Unknown status | Phase 4 | — |
| Ketamine v. Ketorolac for Management of Generalized Tension Type HeadacheNCT03221569 · The Brooklyn Hospital Center | Unknown status | Phase 4 | 1 |
| Ketamine vs. Placebo as Adjunctive Therapies for Severe Alcohol WithdrawalNCT02823977 · University of Colorado, Denver | Withdrawn | Phase 4 | 1 |
| Comparing Ketamine and Propofol Anesthesia for Electroconvulsive TherapyNCT01935115 · University of Saskatchewan | Completed | Phase 4 | 1 |
| Randomised Trial Ketiapine Olanzapine Fast Sedation Agitated Patients Emergency WardNCT03216941 · Universidad Nacional de Rosario | Completed | Phase 4 | 1 |
| Dexamethasone and Ketamine on Change of Postoperative MoodNCT03194594 · Wonkwang University Hospital | Completed | Phase 4 | 1 |
| N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major DepressionNCT01260649 · Massachusetts General Hospital | Terminated | Phase 4 | 1 |
| Treatment Study of Bipolar DepressionNCT00947791 · Icahn School of Medicine at Mount Sinai | Terminated | Phase 4 | 1 |
| Intranasal Ketamine for Late-Life Depression and Suicidal IdeationNCT02295787 · Massachusetts General Hospital | Withdrawn | Phase 4 | — |
| Ketamine For Suicidal IdeationNCT01507181 · James Murrough | Completed | Phase 4 | 1 |
| Effects of Ketamine and Risperidone on CognitionNCT01140620 · University of Manchester | Completed | Phase 4 | 3 |
| Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major DepressionNCT02924090 · University of Manitoba | Unknown status | Phase 4 | 1 |
| Clinical Trial of the Use of Ketamine in Treatment Resistant DepressionNCT02610712 · National Institute of Neurology and Neurosurgery, Mexico | Unknown status | Phase 4 | 1 |
| The Use of Ketamine as an Anaesthetic During Electroconvulsive TherapyNCT01306760 · University of Aberdeen | Completed | Phase 4 | 1 |
| NMDA Antagonists in Bipolar DepressionNCT01833897 · New York State Psychiatric Institute | Completed | Phase 4 | 1 |
| D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant DepressionNCT02772211 · Sheba Medical Center | Unknown status | Phase 4 | 1 |
| A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn PatientsNCT02336308 · University of Colorado, Denver | Withdrawn | Phase 4 | 1 |
| Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive TherapyNCT02305394 · First Affiliated Hospital of Chongqing Medical University | Unknown status | Phase 4 | 1 |
| Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive TherapyNCT02267980 · Inonu University | Unknown status | Phase 4 | 1 |
| Effects of Sevoflurane and Ketamine on QT in Electroconvulsive TherapyNCT01870219 · Inonu University | Completed | Phase 4 | 1 |
| Ketamine as an Anaesthetic Agent in Electroconvulsive Therapy (ECT)NCT00680433 · Northside Clinic, Australia | Completed | Phase 4 | 1 |
| Ketamine Frequency Treatment for Major Depressive DisorderNCT00646087 · Essentia Health | Withdrawn | Phase 4 | 1 |
| Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility TrialNCT05233566 · Washington University School of Medicine | Completed | Phase 3 | 1 |
| Opioid-Free Pain Control Regimen Following Robotic Radical ProstatectomyNCT05597878 · Wake Forest University Health Sciences | Terminated | Phase 2 / Phase 3 | 1 |
| Opiate Suicide Study in Patients With Major DepressionNCT04116528 · Stanford University | Completed | Phase 3 | 1 |
| Predictors of Intravenous Ketamine Response in TRDNCT05625555 · Abraham Nunes | Active, not recruiting | Phase 3 | 1 |
| Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive DiseaseNCT02783430 · University Hospital, Lille | Completed | Phase 2 / Phase 3 | 9 |
| Effects of Ketamine in the Acute Phase of Suicidal IdeationNCT02299440 · Centre Hospitalier Universitaire de Nīmes | Completed | Phase 3 | 9 |
| Ketamine Versus Midazolam for Recurrence of Suicidality in AdolescentsNCT04592809 · University of Texas Southwestern Medical Center | Completed | Phase 3 | 1 |
| The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case SeriesNCT06048263 · Washington University School of Medicine | Withdrawn | Phase 2 / Phase 3 | 1 |
| Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly PatientsNCT07153406 · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | Not yet recruiting | Phase 3 | 9 |
| Esketamine and Perioperative Depressive SymptomsNCT04425473 · Beijing Tiantan Hospital | Completed | Phase 2 / Phase 3 | 1 |
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency DepartmentNCT04260607 · Naval Medical Center Camp Lejeune | Terminated | Phase 3 | 1 |
| Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in AdolescentsNCT06957704 · Federal University of São Paulo | Not yet recruiting | Phase 3 | — |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02417064 · Janssen Research & Development, LLC | Completed | Phase 3 | 90 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02418585 · Janssen Research & Development, LLC | Completed | Phase 3 | 48 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant DepressionNCT02422186 · Janssen Research & Development, LLC | Completed | Phase 3 | 69 |
| A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant DepressionNCT02493868 · Janssen Research & Development, LLC | Completed | Phase 3 | 155 |
| A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant DepressionNCT02497287 · Janssen Research & Development, LLC | Completed | Phase 3 | 109 |
| A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant DepressionNCT02782104 · Janssen Research & Development, LLC | Completed | Phase 3 | 173 |
| 54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03039192 · Janssen Research & Development, LLC | Completed | Phase 3 | 56 |
| 54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03097133 · Janssen Research & Development, LLC | Completed | Phase 3 | 61 |
| A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT03434041 · Janssen Research & Development, LLC | Completed | Phase 3 | 30 |
| A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive DisorderNCT04338321 · Janssen-Cilag International NV | Completed | Phase 3 | 171 |
| A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant DepressionNCT03852160 · Janssen-Cilag International NV | Withdrawn | Phase 3 | — |
| Ketamine As an Adjunctive Therapy for Major Depression (2)NCT04939649 · University of Dublin, Trinity College | Completed | Phase 3 | 1 |
| NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar DepressionNCT03396601 · NeuroRx, Inc. | Unknown status | Phase 3 | 2 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)NCT03113968 · Bo Hu | Completed | Phase 2 / Phase 3 | 5 |
| An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment AlternativesNCT04476446 · Janssen-Cilag, S.A. | Completed | Phase 3 | 8 |
| Ketamine Versus Electroconvulsive Therapy in DepressionNCT03674671 · University of Ottawa | Suspended | Phase 3 | 4 |
| Ketamine for Severe Adolescent Depression: Intermediate-term Safety and EfficacyNCT03889756 · Yale University | Terminated | Phase 2 / Phase 3 | 1 |
| Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol AbuseNCT03539887 · The University of Texas Health Science Center, Houston | Completed | Phase 3 | 1 |
| Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal IdeationNCT05468840 · University of Ottawa | Unknown status | Phase 3 | 1 |
| Ketamine to Prevent PPD After CesareanNCT04227704 · Washington University School of Medicine | Completed | Phase 3 | 1 |
| ECT vs. EsketamineNCT04924257 · Medical University Innsbruck | Withdrawn | Phase 3 | 1 |
| Ketamine for Treatment Resistant Late-Life DepressionNCT02556606 · VA Office of Research and Development | Completed | Phase 3 | 1 |
| Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing TonsillectomyNCT02987985 · University of Saskatchewan | Completed | Phase 3 | 1 |
| Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)NCT02397889 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 / Phase 3 | 1 |
| Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal KetamineNCT04216888 · Dan Iosifescu | Completed | Phase 2 / Phase 3 | 1 |
| Ketamine Infusion for Comorbid PTSD and Chronic PainNCT04322968 · VA Ann Arbor Healthcare System | Completed | Phase 3 | 1 |
| Ketamine and Postoperative Depressive Symptom-PASSIONNCT03086148 · Beijing Tiantan Hospital | Completed | Phase 2 / Phase 3 | 1 |
| The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major DepressionNCT02037503 · Tel-Aviv Sourasky Medical Center | Unknown status | Phase 3 | 1 |
| Study on the Use of Low Dose Ketamine After Gastric Bypass and GastrectomyNCT02452060 · NYU Langone Health | Completed | Phase 2 / Phase 3 | 1 |
| Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency DepartmentNCT03436121 · Maria Pacella | Withdrawn | Phase 2 / Phase 3 | — |
| Endogenous Opioid Modulation by KetamineNCT03051945 · University of Utah | Withdrawn | Phase 3 | 1 |
| Ketamine as an Alternative Treatment to ECT in Major Depressive DisorderNCT02659085 · Pouya Movahed Rad | Completed | Phase 2 / Phase 3 | 1 |
| Evaluation of Schemes of Administration of Intravenous Ketamine in DepressionNCT03742557 · National Institute of Neurology and Neurosurgery, Mexico | Unknown status | Phase 3 | 1 |
| A Study to Decrease Suicidal Thinking Using KetamineNCT02418702 · United States Naval Medical Center, San Diego | Withdrawn | Phase 3 | 1 |
| Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of PainNCT03915938 · Hospital de Clinicas de Porto Alegre | Completed | Phase 2 / Phase 3 | — |
| Action of Ketamine in Treatment-Resistant DepressionNCT01945047 · University of Ottawa | Completed | Phase 2 / Phase 3 | 1 |
| Lamotrigine for Ketamine Dependence TrialNCT02556060 · Taipei City Hospital | Completed | Phase 2 / Phase 3 | 1 |
| Intranasal Ketamine In the Treatment of Pediatric Bipolar DisorderNCT01504659 · Juvenile Bipolar Research Foundation | Terminated | Phase 2 / Phase 3 | 4 |
| The Impact of Ketamine on the Reward Circuitry of Suicidal PatientsNCT02532153 · Massachusetts General Hospital | Withdrawn | Phase 3 | 1 |
| Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six WeeksNCT01557712 · University Hospital, Grenoble | Completed | Phase 3 | 1 |
| Emergency Ketamine Treatment of Suicidal IdeationNCT02183272 · University of Cincinnati | Unknown status | Phase 2 / Phase 3 | 1 |
| To Test the Potential Efficacy of Repeated Intranasal Administration of Ketamine as a Treatment for PTSDNCT02398136 · Adriana Feder | Withdrawn | Phase 2 / Phase 3 | — |
| An Open Prospective Trial of IV Ketamine in Suicidal AdolescentsNCT02048423 · Nationwide Children's Hospital | Unknown status | Phase 2 / Phase 3 | 1 |
| Systemic Ketamine for the Improvement of Post-Operative Analgesia at the Alcohol-Dependent PatientNCT00329394 · University Hospital, Clermont-Ferrand | Suspended | Phase 3 | 1 |
| Electrophysiologic Mechanisms of Ketamine Antidepressant ResponseNCT07768618 · Emory University | Not yet recruiting | Phase 2 | 1 |
| Understanding How Ketamine Brings About Rapid Improvement in OCDNCT02624596 · Stanford University | Completed | Phase 2 | 1 |
| A Study of Ketamine Infusions to Treat Clinically-depressed ICU PatientsNCT05803551 · Mayo Clinic | Terminated | Phase 2 | 1 |
| Ketamine-enhanced Prolonged Exposure Therapy in PTSDNCT04560660 · VA Office of Research and Development | Completed | Phase 2 | 1 |
| Ketamine for Methamphetamine Use DisorderNCT06496750 · University of Texas Southwestern Medical Center | Active, not recruiting | Phase 2 | 5 |
| A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive DisorderNCT06340958 · Clexio Biosciences Ltd. | Completed | Phase 2 | 23 |
| A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major DepressionNCT07396272 · Daniel Lindqvist | Active, not recruiting | Phase 2 | 1 |
| Ketamine Effects on Learning In Eating DisordersNCT06736769 · Amanda Downey, MD | Enrolling by invitation | Phase 2 | 1 |
| Adjunctive Oral KET-AD Capsules in Treatment Resistant Bipolar DepressionNCT07644767 · Neurocentrx Pharma Pty Ltd | Not yet recruiting | Phase 2 | — |
| Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002NCT06816433 · Global Coalition for Adaptive Research | Suspended | Phase 2 | 9 |
| KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn InjuryNCT07563296 · Irma Fleming | Not yet recruiting | Phase 2 | 1 |
| Ketamine-Assisted Psychotherapy for Treatment-Resistant DepressionNCT07247006 · University of Rochester | Not yet recruiting | Phase 2 | 1 |
| Ketamine for Treatment-Resistant Bipolar DisorderNCT05004896 · Joshua Rosenblat | Completed | Phase 2 | 3 |
| Maintenance Ketamine Infusions for Treatment-Resistant Bipolar DepressionNCT05339074 · Joshua Rosenblat | Completed | Phase 2 | 3 |
| Repeated Neurocognitive Measurements in Depressed PatientsNCT05991232 · Jay Fournier | Withdrawn | Phase 1 / Phase 2 | 1 |
| Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery EnhancementNCT07369089 · University of California, San Diego | Not yet recruiting | Phase 2 | 2 |
| Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)NCT06795659 · The University of Texas Health Science Center at San Antonio | Completed | Phase 1 / Phase 2 | 1 |
| Ayahuasca and Esketamine for Major DepressionNCT07212946 · University of Sao Paulo | Completed | Phase 2 | 1 |
| Ketamine for the Treatment of Depression in Parkinson's DiseaseNCT04944017 · Yale University | Completed | Phase 2 | 1 |
| Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL)NCT07247370 · South West Sydney Local Health District | Not yet recruiting | Phase 1 / Phase 2 | 1 |
| Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use DisorderNCT05421065 · Peggy C Nopoulos | Active, not recruiting | Phase 2 | 1 |
| FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar DepressionNCT06620042 · Brian Barnett | Completed | Phase 2 | 2 |
| A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO StudyNCT04103892 · Clexio Biosciences Ltd. | Completed | Phase 2 | 46 |
| Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.NCT07180095 · Liaquat National Hospital & Medical College | Not yet recruiting | Phase 1 / Phase 2 | — |
| Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous KetamineNCT04613453 · Yale University | Terminated | Phase 2 | 1 |
| Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSDNCT07009158 · Queen's University | Not yet recruiting | Phase 1 / Phase 2 | — |
| Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic TargetsNCT05046184 · University of Texas Southwestern Medical Center | Completed | Phase 2 | 1 |
| A Study of Ketamine in Patients With Treatment-resistant DepressionNCT01627782 · Janssen Research & Development, LLC | Completed | Phase 2 | 13 |
| A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant DepressionNCT01640080 · Janssen Research & Development, LLC | Completed | Phase 2 | 9 |
| A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant DepressionNCT01998958 · Janssen Research & Development, LLC | Completed | Phase 2 | 25 |
| A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for SuicideNCT02133001 · Janssen Research & Development, LLC | Completed | Phase 2 | 14 |
| A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant DepressionNCT02918318 · Janssen Pharmaceutical K.K. | Completed | Phase 2 | 43 |
| Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for SuicideNCT03185819 · Janssen Research & Development, LLC | Completed | Phase 2 | 51 |
| Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderNCT02461927 · VA Office of Research and Development | Completed | Phase 1 / Phase 2 | 1 |
| Ketamine for OUD and Suicidal Ideation in the EDNCT06111339 · Brigham and Women's Hospital | Terminated | Phase 2 | 1 |
| Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive ImpairmentNCT06069843 · Icahn School of Medicine at Mount Sinai | Active, not recruiting | Phase 2 | 1 |
| Ketamine for the Treatment for Alcohol Use Disorder in the EDNCT05661669 · Brigham and Women's Hospital | Withdrawn | Phase 2 | 1 |
| Ketamine Infusion for Rapid Reduction of Suicidality in PediatricsNCT04955470 · University of British Columbia | Terminated | Phase 1 / Phase 2 | 1 |
| Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSDNCT04889664 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 | 1 |
| Repeated Neurocognitive Measurements in Depressed PatientsNCT04916548 · Rebecca Price | Completed | Phase 1 / Phase 2 | 1 |
| Ketamine + Mindfulness for DepressionNCT05168735 · Rebecca Price | Completed | Phase 1 / Phase 2 | 1 |
| Ketamine for the Treatment of Opioid Use Disorder and DepressionNCT04177706 · Medical University of South Carolina | Completed | Phase 2 | 1 |
| A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRDNCT05414422 · Perception Neuroscience | Completed | Phase 2 | 21 |
| KAP for Depression in Abstinent Opioid UsersNCT05193318 · Medical University of South Carolina | Terminated | Phase 2 | 1 |
| Efficacy of Repeated Ketamine Infusions for Treatment-resistant DepressionNCT02360280 · VA Office of Research and Development | Completed | Phase 2 | 1 |
| Intravenous Ketamine Plus Neurocognitive Training for DepressionNCT03237286 · Rebecca Price | Completed | Phase 1 / Phase 2 | 1 |
| Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSDNCT06036511 · University of New Mexico | Withdrawn | Phase 1 / Phase 2 | 1 |
| Ketamine Treatment for PTSD and MDD in TBINCT06228391 · Minneapolis Veterans Affairs Medical Center | Not yet recruiting | Phase 2 | 1 |
| Ketamine or Placebo in Patients With Major Depression and Advanced CancerNCT04471818 · Instituto Nacional de Cancerologia de Mexico | Completed | Phase 1 / Phase 2 | 1 |
| A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of SuicideNCT04669665 · Seelos Therapeutics, Inc. | Completed | Phase 2 | 21 |
| Open Label Ketamine Treatment for Major Depressive Disorder in VeteransNCT03053830 · VA Connecticut Healthcare System | Completed | Phase 2 | 1 |
| Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant DepressionNCT05323019 · Zylorion Health | Terminated | Phase 2 | 1 |
| Trial of Ketamine and Lithium Therapy in Bipolar DepressionNCT01768767 · Yale University | Withdrawn | Phase 2 | — |
| Ketamine to Improve Recovery After Cesarean Delivery - Part 1NCT04037085 · Grace Lim, MD, MS | Completed | Phase 2 | 2 |
| Repeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension StudyNCT05438758 · Zylorion Health | Withdrawn | Phase 2 | — |
| Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure TherapyNCT02727998 · Yale University | Terminated | Phase 2 | 1 |
| The Effects of Sedatives on Tobacco Use DisorderNCT03813121 · Wake Forest University Health Sciences | Completed | Phase 1 / Phase 2 | 1 |
| Ketamine and Epigenetic AgingNCT05294835 · TruDiagnostic | Unknown status | Phase 2 | 1 |
| miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment OutcomeNCT02418195 · University of Alabama at Birmingham | Completed | Phase 2 | 1 |
| Combined Ketamine and eCBT Intervention for PTSDNCT04771767 · Queen's University | Unknown status | Phase 2 | 1 |
| CAP-Ketamine for Antidepressant Resistant PTSDNCT02655692 · VA Office of Research and Development | Completed | Phase 2 | 3 |
| Psilocybin Versus Ketamine in Treatment-Resistant DepressionNCT05383313 · National Institute of Mental Health, Czech Republic | Unknown status | Phase 2 | 1 |
| Study of Ketamine for Depression in Cancer Patients Receiving Palliative CareNCT03410446 · University Health Network, Toronto | Completed | Phase 2 | 1 |
| Intramuscular Ketamine for Suicidal IdeationNCT05105061 · Icahn School of Medicine at Mount Sinai | Withdrawn | Phase 2 | 1 |
| Low Dose Intravenous Ketamine in Treatment Resistant Depression PatientsNCT02935595 · The University of Texas Health Science Center, Houston | Completed | Phase 2 | 1 |
| Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum DepressionNCT04011592 · The University of Texas Health Science Center, Houston | Terminated | Phase 2 | 1 |
| Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant DepressionNCT03756129 · Novartis Pharmaceuticals | Completed | Phase 2 | 12 |
| Ketamine for Reduction of Alcoholic RelapseNCT02649231 · University College, London | Completed | Phase 2 | 2 |
| Sequential Therapy for the Treatment of Severe Bipolar Depression.NCT02974010 · NeuroRx, Inc. | Completed | Phase 2 | 4 |
| A Single Ketamine Infusion Combined With Music for Suicidal IdeationNCT04658420 · The University of Texas Health Science Center at Tyler | Unknown status | Phase 2 | 1 |
| Ketamine and Prolonged Exposure in PTSDNCT03960658 · Minneapolis Veterans Affairs Medical Center | Completed | Phase 1 / Phase 2 | 1 |
| Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar DepressionNCT03965871 · Celon Pharma SA | Completed | Phase 2 | 12 |
| Effect of Ketamine Intranasal Spray in Treatment of Chronic Cluster HeadacheNCT04179266 · CCH Pharmaceuticals | Completed | Phase 1 / Phase 2 | 1 |
| The UTHealth Ketamine ProjectNCT02882711 · The University of Texas Health Science Center, Houston | Terminated | Phase 2 | 1 |
| Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)NCT02422290 · New York State Psychiatric Institute | Completed | Phase 1 / Phase 2 | 1 |
| Examining the Impact of Sirolimus on Ketamine's Antidepressant EffectsNCT02487485 · Yale University | Completed | Phase 2 | 2 |
| Ketamine and Nitroprusside for DepressionNCT03102736 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 | 1 |
| Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant DepressionNCT03965858 · Celon Pharma SA | Completed | Phase 2 | 12 |
| Ketamine for Suicidality in Bipolar DepressionNCT01944293 · New York State Psychiatric Institute | Completed | Phase 1 / Phase 2 | 1 |
| Ketamine in Adolescents With Treatment-Resistant DepressionNCT02078817 · University of Minnesota | Completed | Phase 2 | 1 |
| The Effect of Intravenous Ketamine on Non Suicidal Self Injuries.NCT04242914 · Tel-Aviv Sourasky Medical Center | Unknown status | Phase 1 / Phase 2 | 1 |
| Ketamine in the Treatment of DepressionNCT01558063 · Columbia University | Completed | Phase 2 | 1 |
| Investigation of Antidepressant Efficacy of Oral Ketamine TreatmentNCT02992496 · Medical University of Vienna | Unknown status | Phase 2 | 1 |
| ED Treatment of Suicidal Patients With Ketamine InfusionNCT03502551 · University of California, Davis | Withdrawn | Phase 2 | 1 |
| Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin TransporterNCT02717052 · Medical University of Vienna | Unknown status | Phase 2 | 1 |
| Rapid Antidepressant Effects of Ketamine in Major DepressionNCT00088699 · National Institute of Mental Health (NIMH) | Completed | Phase 1 / Phase 2 | 1 |
| Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department PatientsNCT02106325 · NYU Langone Health | Completed | Phase 2 | 2 |
| Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderNCT03658330 · VA Connecticut Healthcare System | Completed | Phase 2 | — |
| Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving KetamineNCT03290963 · William V. Bobo, M.D. | Withdrawn | Phase 2 | 1 |
| Ketamine Plus Lithium in Treatment-Resistant DepressionNCT01880593 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 | 1 |
| Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)NCT01920555 · Massachusetts General Hospital | Completed | Phase 2 | 6 |
| Efficacy and Safety of TAK-653 in Treatment-Resistant DepressionNCT03312894 · Millennium Pharmaceuticals, Inc. | Withdrawn | Phase 2 | — |
| Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)NCT00749203 · Dennis Charney | Completed | Phase 2 | 1 |
| Intravenous Ketamine in the Treatment of Obsessive-Compulsive DisorderNCT01371110 · Wayne Goodman MD | Terminated | Phase 1 / Phase 2 | 1 |
| Psilocybin and DepressionNCT03380442 · University of Helsinki | Unknown status | Phase 2 | — |
| Ketamine for Depression and Suicide RiskNCT02094898 · Mayo Clinic | Completed | Phase 2 | 1 |
| Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive DisorderNCT00956085 · New York State Psychiatric Institute | Completed | Phase 2 | 1 |
| A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive DisorderNCT02234011 · Mclean Hospital | Terminated | Phase 2 | 1 |
| Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With OCDNCT02206776 · New York State Psychiatric Institute | Terminated | Phase 2 | 1 |
| Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD)NCT01100255 · New York State Psychiatric Institute | Completed | Phase 2 | 1 |
| A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive DisorderNCT01957410 · Janssen Research & Development, LLC | Terminated | Phase 2 | 1 |
| Sevoflurane Associated With Oral Midazolam and Ketamine for Dental SedationNCT02284204 · Universidade Federal de Goias | Completed | Phase 2 | 1 |
| Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)NCT02062658 · New York State Psychiatric Institute | Completed | Phase 2 | 1 |
| Oral Ketamine in the Treatment of Depression and Anxiety in Patients With CancerNCT01680172 · Mayo Clinic | Terminated | Phase 2 | 2 |
| Study of Depression-Ketamine-Brain FunctionNCT01135758 · Markus KOSEL | Terminated | Phase 2 | 1 |
| The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With DepressionNCT01809340 · Janssen Research & Development, LLC | Terminated | Phase 2 | 12 |
| Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican PopulationNCT01868802 · Paul J. Lamothe | Unknown status | Phase 2 | 1 |
| Ketamine Infusion for Obsessive-Compulsive DisorderNCT01349231 · Yale University | Completed | Phase 2 | 1 |
| Optimization of IV Ketamine for Treatment Resistant DepressionNCT00768430 · Baylor College of Medicine | Completed | Phase 2 | 2 |
| A Study of Ketamine as an AntidepressantNCT01441505 · The University of New South Wales | Unknown status | Phase 2 | 1 |
| Study of Ketamine as an Antidepressant in Major Depressive DisorderNCT01573741 · Shi Jinyun | Unknown status | Phase 1 / Phase 2 | 1 |
| Oral and Sublingual KetamineNCT07683988 · Western University, Canada | Not yet recruiting | Phase 1 | — |
| Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean DeliveryNCT06767566 · University of Utah | Suspended | Phase 1 | 1 |
| Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural ConnectomeNCT06698848 · Massachusetts General Hospital | Active, not recruiting | Phase 1 | 1 |
| KET-RO Plus RO DBT for Treatment Resistant DepressionNCT06138691 · Washington University School of Medicine | Completed | Phase 1 | 1 |
| Ketamine Biomarker ValidationNCT07307768 · Soterix Medical | Not yet recruiting | Phase 1 | 1 |
| Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)NCT05907213 · Grace Lim, MD, MS | Completed | Phase 1 | 1 |
| Repeated Ketamine Infusions for Comorbid PTSD and MDD in VeteransNCT04032301 · University of Minnesota | Completed | Phase 1 | 1 |
| A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive DisorderNCT02919579 · Janssen Research & Development, LLC | Completed | Phase 1 | 1 |
| A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant DepressionNCT05268497 · Janssen Research & Development, LLC | Withdrawn | Phase 1 | 5 |
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot TrialNCT03367533 · Yale University | Completed | Phase 1 | 1 |
| Phase 1 Evaluation of (2R,6R)-HydroxynorketamineNCT04711005 · National Institute of Mental Health (NIMH) | Completed | Phase 1 | 1 |
| The Effect of Ketamine on Aesthetics and Role for Antidepressant EffectsNCT05320107 · Medical University of Vienna | Unknown status | Phase 1 | 1 |
| Ketamine for OUD and Comorbid Depression (OUDCD)NCT05051449 · University of Maryland, Baltimore | Terminated | Phase 1 | 1 |
| [11C]-(R)-Rolipram to Measure cAMP Signaling Before and After KetamineNCT05522673 · National Institute of Mental Health (NIMH) | Terminated | Phase 1 | 1 |
| Imaging Neural Correlates of Ketamine Using PET/MRNCT04587778 · Medical University of Vienna | Unknown status | Phase 1 | 1 |
| Spreading Depolarization and Ketamine SuppressionNCT02501941 · University of New Mexico | Completed | Phase 1 | 1 |
| Ketamine Trial for the Treatment of DepressionNCT02401139 · The University of New South Wales | Completed | Phase 1 | 2 |
| Modified Ketogenic Diet and Ketamine for Anorexia NervosaNCT04714541 · Homeostasis Therapeutics, LLC | Completed | Phase 1 | 1 |
| A Study of HR071603(Ketamine Nasal Spray) in Healthy SubjectsNCT04108234 · Jiangsu HengRui Medicine Co., Ltd. | Completed | Phase 1 | 1 |
| Use of Transmucosal Ketamine in Post Stroke DepressionNCT04876066 · West Virginia University | Unknown status | Phase 1 | 1 |
| Ketamine Interleaved With Electroconvulsive Therapy for DepressionNCT04082858 · St Patrick's Hospital, Ireland | Terminated | Phase 1 | 1 |
| The Role of HNKs in the Antidepressant Effect of KetamineNCT03977675 · Columbia University | Terminated | Phase 1 | 1 |
| Ketamine for Low Mood States in the ERNCT01209845 · Yale University | Completed | Phase 1 | 1 |
| Intravenous Ketamine Effects on Functional NeuroanatomyNCT04205890 · Neurological Associates of West Los Angeles | Withdrawn | Phase 1 | 1 |
| Ketamine for Depression and Alcohol DependenceNCT01551329 · Yale University | Completed | Phase 1 | 1 |
| Ketamine as an Adjunctive Therapy for Major DepressionNCT03256162 · St Patrick's Hospital, Ireland | Completed | Phase 1 | 1 |
| Ketamine for Relapse Prevention in Recurrent Depressive DisorderNCT02661061 · St Patrick's Hospital, Ireland | Terminated | Phase 1 | 1 |
| A Study To Examine The Effects Of PF-04958242 On Ketamine-Induced Cognitive Impairment In Healthy VolunteersNCT01749098 · Biogen | Completed | Phase 1 | 2 |
| Biomarkers of Fast Acting Therapies in Major DepressionNCT02165449 · University of California, Los Angeles | Completed | Phase 1 | 1 |
| Ketamine Infusions for PTSD and Treatment-Resistant DepressionNCT02577250 · Minneapolis Veterans Affairs Medical Center | Completed | Phase 1 | 1 |
| Ketamine for Major Depressive DisorderNCT03721900 · Shenox Pharmaceuticals, LLC | Unknown status | Phase 1 | 3 |
| Touchscreen-based Cognitive Tests in Healthy VolunteersNCT03469089 · University of Eastern Finland | Unknown status | Phase 1 | 1 |
| Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)NCT02911597 · Stanford University | Completed | Phase 1 | 1 |
| A Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy MalesNCT02935725 · Autifony Therapeutics Limited | Completed | Phase 1 | 1 |
| Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous KetamineNCT02289248 · Yale University | Completed | Phase 1 | 2 |
| Parallel Effects of Schizophrenia and N-methyl-D-aspartate (NMDA) AntagonismNCT02675530 · Yale University | Completed | Phase 1 | 1 |
| Subanesthetic IV Bolus Ketamine in the Treatment of Acute DepressionNCT02378415 · United States Naval Medical Center, San Diego | Terminated | Phase 1 | 1 |
| Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female SubjectsNCT01046630 · AstraZeneca | Completed | Phase 1 | 2 |
| Continuation Ketamine in Major DepressionNCT00548964 · James Murrough | Completed | Phase 1 | 1 |
| Ketamine Challenge Study With JNJ-40411813NCT01101659 · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Completed | Phase 1 | 1 |
| The Effect of Ketamine on AttentivenessNCT01165294 · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Completed | Phase 1 | — |
| Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic CancerNCT05086250 · Cedars-Sinai Medical Center | Completed | Early Phase 1 | 1 |
| Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:NCT03573349 · Mayo Clinic | Active, not recruiting | Early Phase 1 | 1 |
| Transition From Acute to Chronic Opioid Use and Chronic PainNCT07211399 · Jacques E. Chelly | Withdrawn | Early Phase 1 | 1 |
| The Effects of Sedatives on Tobacco Use Disorder Version 2NCT05505630 · Wake Forest University Health Sciences | Completed | Early Phase 1 | 1 |
| Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)NCT06378528 · University of Wisconsin, Madison | Suspended | Early Phase 1 | 1 |
| Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use DisorderNCT05796791 · Medical University of South Carolina | Completed | Early Phase 1 | 1 |
| Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer PatientsNCT06665568 · University of Zurich | Not yet recruiting | Early Phase 1 | 1 |
| Ketamine and Lidocaine Infusion in Refractory Chronic MigraineNCT06935552 · Assiut University | Not yet recruiting | Early Phase 1 | — |
| Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI CancersNCT06001372 · University of Utah | Terminated | Early Phase 1 | 1 |
| EEG Characteristics in ECTNCT04022226 · University of New Mexico | Completed | Early Phase 1 | 1 |
| Inpatient Single Dose Interventions for Alcohol Use DisorderNCT04562779 · Denver Health and Hospital Authority | Completed | Early Phase 1 | 1 |
| Ketamine-Assisted PsychoTherapy ViAbility in Treating Cancer-related Emotional DistressNCT05344625 · Northwell Health | Withdrawn | Early Phase 1 | — |
| Effect of Esketamine on Reducing Postoperative Anxiety and Depression in Adolescent PatientsNCT06073015 · Henan Provincial People's Hospital | Unknown status | Early Phase 1 | — |
| Intranasal Ketamine for Suicidal Ideation in VeteransNCT03788694 · Bronx Veterans Medical Research Foundation, Inc | Withdrawn | Early Phase 1 | 1 |
| Glutamate and Opioid Mechanisms of Antidepressant Response to KetamineNCT04977674 · King's College London | Completed | Early Phase 1 | 1 |
| Low-Dose Intravenous Ketamine for Adolescents With Depression and Suicidal Ideation in the Emergency DepartmentNCT05217706 · Rady Children's Hospital, San Diego | Unknown status | Early Phase 1 | 1 |
| S-ketamin Premedication in Pediatric EENT SurgeryNCT04757675 · Eye & ENT Hospital of Fudan University | Completed | Early Phase 1 | 1 |
| Examining The Effect Of Ketamine On Glutamate/Glutamine CyclingNCT02037035 · Yale University | Completed | Early Phase 1 | 1 |
| The Effectiveness and Safety of Esketamine in Modified Electroconvulsive TherapyNCT04777110 · First Affiliated Hospital of Chongqing Medical University | Unknown status | Early Phase 1 | — |
| Ketamine for Depression Relapse Prevention Following ECTNCT02414932 · St Patrick's Hospital, Ireland | Completed | Early Phase 1 | 1 |
| Ketamine Infusion for Social Anxiety DisorderNCT02083926 · Yale University | Completed | Early Phase 1 | 1 |
| Ketamine for Mood Disorders With Suicidal IdeationNCT04099771 · The Miriam Hospital | Unknown status | Early Phase 1 | 1 |
| Ketamine for Refractory Chronic Migraine: a Pilot StudyNCT03896256 · Thomas Jefferson University | Completed | Early Phase 1 | 1 |
| A Multimodal Neuroimaging Study of Brain Activation Patterns Under KetamineNCT03609190 · Psychiatric University Hospital, Zurich | Completed | Early Phase 1 | — |
| Ketamine for Preventing Depression in Patients Undergoing Treatment for Pancreatic or Head and Neck CancersNCT02442739 · Cedars-Sinai Medical Center | Withdrawn | Early Phase 1 | 1 |
| Study of Oral Ketamine Versus Placebo for Treating Depression in Patients Undergoing Treatment for CancerNCT02836288 · Scott A. Irwin, MD, PhD | Completed | Early Phase 1 | 1 |
| Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.NCT02593643 · Sunnybrook Health Sciences Centre | Completed | Early Phase 1 | 1 |
| Effect of Ketamine and Etomidate During RSI on Long Term OutcomesNCT06179485 · Vanderbilt University Medical Center | Enrolling by invitation | N/A | 6 |
| Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of OpioidsNCT05752799 · G.Gennimatas General Hospital | Active, not recruiting | Not applicable | 1 |
| Using Virtual Reality to Control the Audio-visual Inputs During Ketamine/Esketamine TreatmentNCT06139016 · Yale University | Completed | Not applicable | 1 |
| Biomarker Discovery for Suicide Precision Circuit TherapeuticsNCT07723066 · Massachusetts General Hospital | Not yet recruiting | N/A | — |
| Phenomenological Explorations of the Esketamine-Induced Transient Dissociative StateNCT06133309 · Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer | Completed | Not applicable | 1 |
| Imaging SV2A in Mood DisordersNCT02734602 · Yale University | Active, not recruiting | Not applicable | 1 |
| Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot StudyNCT07614581 · Adriaan Dirk van der Wart | Not yet recruiting | N/A | 1 |
| Multimodal Pharmacological Study of Clinical Cohorts for Major Depressive DisorderNCT07602153 · Shanghai Mental Health Center | Not yet recruiting | N/A | — |
| The Effects of Ketamine on Respiratory Stimulation and Transpulmonary PressuresNCT01969227 · Massachusetts General Hospital | Completed | Not applicable | 2 |
| Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive DisorderNCT07526454 · Tanta University | Completed | Not applicable | 1 |
| Treatment Response In ECT PatientsNCT07463911 · Nurdan Sağbaş | Active, not recruiting | N/A | 1 |
| Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee ArthroplastyNCT07059429 · State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | Completed | Not applicable | 1 |
| Esketamine for Prevention of Depression After Cytoreductive Surgery in Ovarian CancerNCT06624878 · Zhejiang Cancer Hospital | Completed | Not applicable | 1 |
| Mitochondrial Function After KetamineNCT07399756 · Sheba Medical Center | Not yet recruiting | N/A | 1 |
| Psychotherapy Combined With Intranasal Esketamine for the Treatment of Suicidal IdeationNCT07396220 · University of California, San Diego | Enrolling by invitation | Not applicable | 1 |
| Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe DepressionNCT07374198 · Chinese PLA General Hospital | Not yet recruiting | Not applicable | — |
| Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe DepressionNCT07374211 · Chinese PLA General Hospital | Not yet recruiting | Not applicable | — |
| Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer SurgeryNCT07367542 · Chinese PLA General Hospital | Not yet recruiting | Not applicable | 1 |
| Role Of Non-Specific Effects in The Treatment of Depression With EsketamineNCT05910775 · Yale University | Terminated | Not applicable | 1 |
| Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine TreatmentNCT05719909 · University of Pittsburgh | Suspended | Not applicable | 1 |
| Comparison of Propofol and Ketofol as Induction Agents for Electroconvulsive TherapyNCT07273851 · Fauji Foundation Hospital | Completed | Not applicable | 1 |
| Effect of Esketamine on Perioperative Negative Mood in Patients Undergoing Cardiac Valve SurgeryNCT06608030 · Chinese PLA General Hospital | Completed | Not applicable | 2 |
| Outcome of Multimodal Anesthesia BernNCT06985069 · Insel Gruppe AG, University Hospital Bern | Completed | Not applicable | 1 |
| Behavioural Activation Therapy and Esketamine for Resistant DepressionNCT06431386 · The Royal's Institute of Mental Health Research | Terminated | Not applicable | 1 |
| Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and AnhedoniaNCT07199179 · University Hospital, Montpellier | Active, not recruiting | N/A | 1 |
| Effect of Esketamine on Anxiety State in Patients Undergoing Abdominal Tumor SurgeryNCT06530706 · Zhejiang Cancer Hospital | Completed | Not applicable | 1 |
| Esketamine vs ECT for Acute SuicidalityNCT06355180 · Capital Medical University | Completed | Not applicable | 6 |
| 2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy RecommendationNCT07097025 · Dr.Yoav Domany | Completed | N/A | 2 |
| Chart Review of Patients Undergoing Ketamine Treatments for DepressionNCT07099235 · Sunnybrook Health Sciences Centre | Completed | N/A | 1 |
| Opioid-based Versus Opioid-free Endotracheal IntubationNCT06464393 · Aretaieion University Hospital | Completed | Not applicable | 1 |
| Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse PreventionNCT04760652 · Yale University | Completed | Not applicable | 3 |
| Long Term Follow Up KET-PDNCT06164756 · Yale University | Enrolling by invitation | N/A | 1 |
| Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)NCT03829579 · Janssen Research & Development, LLC | Approved for marketing | N/A | — |
| (GluEsk) Glutamate and EsketamineNCT06432322 · University of Oxford | Completed | Not applicable | 1 |
| Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)NCT05565352 · Medical University of Gdansk | Enrolling by invitation | N/A | 1 |
| Sustained Ketamine Effectiveness for Suicidal IdeationNCT06806475 · University Hospital, Montpellier | Completed | N/A | 1 |
| Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on SuicidalityNCT04101474 · Assiut University | Completed | Not applicable | 1 |
| Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar DepressionNCT05177146 · Centre for Addiction and Mental Health | Completed | Not applicable | 1 |
| Synaptic Imaging and Network Activity in Treatment Resistant DepressionNCT05870501 · King's College London | Completed | Not applicable | 1 |
| Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG)NCT05095792 · Entheon Biomedical Corp. | Terminated | N/A | 1 |
| Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant DepressionNCT04239963 · Mclean Hospital | Completed | N/A | 1 |
| Brain Network Dynamics of Depression During Esketamine TreatmentNCT06012916 · University of North Carolina, Chapel Hill | Completed | N/A | 1 |
| Chart Review of Patients Undergoing Ketamine InfusionsNCT04209296 · Brain and Cognition Discovery Foundation | Completed | N/A | 1 |
| Esketamine on Postpartum Depression in Cesarean Section WomenNCT04860661 · Ailin Luo | Completed | Not applicable | 1 |
| The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric SurgeryNCT05591105 · Tiva Group | Completed | N/A | 1 |
| Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal IdeationNCT06366334 · Children's Hospital of Eastern Ontario | Unknown status | Not applicable | 1 |
| Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant DepressionNCT06232291 · Medical University of Gdansk | Completed | N/A | 1 |
| Glutamate Emotion Memory StudyNCT05809609 · University of Oxford | Unknown status | Not applicable | 1 |
| Dose Low Dose Ketamine in CasesarianNCT06237569 · Inonu University | Unknown status | N/A | 1 |
| Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve GastrectomyNCT06199011 · The Second Hospital of Anhui Medical University | Unknown status | Not applicable | — |
| Auditory MMN EEG in TRD in Response to KetamineNCT05464264 · Unity Health Toronto | Unknown status | N/A | 1 |
| Tolerance and Potential Synergistic Effect of the Combination of Intranasal Esketamine and Non-selective MAOINCT05530668 · University Hospital, Strasbourg, France | Completed | N/A | 1 |
| A Naturalistic Study of Ketamine for Treatment Resistant Mood DisordersNCT04226963 · Medical University of Gdansk | Completed | N/A | 1 |
| Naturalistic Study of Ketamine in the Treatment of DepressionNCT05249309 · Hospital de Clinicas de Porto Alegre | Unknown status | N/A | 2 |
| Treatment Resistant Depression (Pilot)NCT01179009 · Washington University School of Medicine | Completed | Not applicable | 1 |
| Prospective Multicentre Study of the Use of Ketamine in the Treatment of Refractory Chronic Pain in the French CLCCNCT04459234 · Centre Leon Berard | Completed | N/A | 12 |
| Intranasal Ketamine in Ultra-REsistant Depression (SURE-ECT Non Responders)NCT05137938 · Centre for Addiction and Mental Health | Completed | Not applicable | 1 |
| Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces CohortNCT05855876 · Stella Center | Unknown status | N/A | 1 |
| In Vitro Modeling of Drug-resistant Psychiatric Disorders Using Induced Pluripotent CellsNCT05887310 · University of Milano Bicocca | Unknown status | N/A | 1 |
| The Role of Ketamine and Dexmedetomidine in Opioid-Sparing AnalgesiaNCT05474183 · Fayoum University Hospital | Completed | Not applicable | 1 |
| Low-dose S-Ketamine and Postpartum Depression in Parturients With Prenatal DepressionNCT03927378 · Peking University First Hospital | Completed | Not applicable | 7 |
| Low-dose S-ketamine in Women With Prenatal DepressionNCT04414943 · Peking University First Hospital | Completed | Not applicable | 7 |
| Reward Emotion Learning and Ketamine StudyNCT04850911 · University of Oxford | Unknown status | Not applicable | 1 |
| Opioid-free Anesthesia in Laparoscopic CholecystectomiesNCT05089526 · Aretaieion University Hospital | Unknown status | Not applicable | 1 |
| Opioid Free Anesthesia and Major Spine SurgeryNCT03417193 · Lebanese American University | Completed | Not applicable | 1 |
| Lidocaine and Magnesium and Ketamine in Gynecological SurgeryNCT04622904 · Aretaieion University Hospital | Unknown status | Not applicable | 1 |
| Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamineNCT04858711 · Aretaieion University Hospital | Unknown status | Not applicable | 1 |
| Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in DepressionNCT04701866 · Douglas Mental Health University Institute | Completed | Not applicable | 2 |
| Effect of Low-dose Esketamine on Postoperative Depression in Patients With Breast CancerNCT04850937 · Yangzhou University | Completed | Not applicable | 1 |
| Study on Opioid-free Anesthesia Protocol With S-ketamine and PropofolNCT05242081 · The First Affiliated Hospital with Nanjing Medical University | Unknown status | Not applicable | 1 |
| Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine SprayNCT04843462 · Lukas Pezawas | Unknown status | Not applicable | 1 |
| Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar DisorderNCT05209217 · Mclean Hospital | Unknown status | N/A | 1 |
| Intravenous Esketamine on Prevention of Postoperative Depression in Patients Undergoing Cardiac SurgeryNCT05155969 · Anshi Wu | Unknown status | Not applicable | 2 |
| Ketamine/Placebo Family History Positive StudyNCT00588952 · Yale University | Completed | Not applicable | 1 |
| Pharmacogenetics Associated With IV KetamineNCT04695405 · Brain and Cognition Discovery Foundation | Completed | N/A | 1 |
| Cognitive Recovery After Electroconvulsive Therapy and General AnesthesiaNCT02761330 · Washington University School of Medicine | Completed | Not applicable | 1 |
| Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic KetamineNCT04856124 · Psych Atlanta | Completed | N/A | 1 |
| Cognitive Dysfunction After Cataract SurgeryNCT04730596 · Tanta University | Completed | Not applicable | 1 |
| Esketamine Adjuvant Therapy for Patients With Chronic Visceral Pain Comorbid Major Depressive DisorderNCT04847245 · Peking University | Unknown status | Not applicable | — |
| Ketamine IV Classic Protocol : Five Years Follow upNCT04824157 · Sheba Medical Center | Completed | N/A | 1 |
| Ketamine Infusion Therapy for the Treatment of PTSD in ParamedicsNCT03947099 · Klarisana Physician Services PLLC | Completed | N/A | 1 |
| The Efficacy and Safety of S-ketamine in Elective Cesarean SectionNCT04657107 · Beijing Obstetrics and Gynecology Hospital | Unknown status | Not applicable | — |
| Ketamine's Actions on Rumination Mechanisms as an AntidepressantNCT04656886 · King's College London | Completed | Not applicable | — |
| Opioid Free Anesthesia in Bariatric SurgeryNCT03507634 · Lebanese American University | Completed | Not applicable | 1 |
| Substance Misuse To Psychosis for Ketamine (SToP-K)NCT03485339 · The University of Hong Kong | Completed | N/A | 2 |
| The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)NCT04399070 · Yan Qiu | Unknown status | Not applicable | 1 |
| Low Dose Ketamine Infusion for the Treatment of Resistant DepressionNCT04283058 · Loma Linda University | Withdrawn | N/A | 1 |
| Neurocognitive Features of Patients With Treatment-Resistant DepressionNCT03134066 · Massachusetts General Hospital | Completed | N/A | — |
| Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant DepressionNCT03027362 · Yale University | Completed | Not applicable | 1 |
| Pediatric Laser Acupuncture and Renal BiopsyNCT01879826 · University of California, San Francisco | Completed | Not applicable | 2 |
| Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant DepressionNCT02522377 · The Cleveland Clinic | Completed | Not applicable | 1 |
| Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related PainNCT04057989 · Defense and Veterans Center for Integrative Pain Management | Completed | N/A | 1 |
| Ketamine for Treatment Resistant MDDNCT04021433 · Hadassah Medical Organization | Unknown status | Not applicable | 1 |
| Personality Disorders and Substance Use Disorders in a Sexual Context in the Man Having Sex With Other Men PopulationNCT03753737 · Hospices Civils de Lyon | Completed | N/A | 1 |
| Effect of Ketamine in Depressive Symptoms of Elderly Patients With Visual Impairment.NCT03473431 · Instituto Mexicano del Seguro Social | Completed | Not applicable | 1 |
| Ketamine Infusion Therapy for PTSD in Combat VeteransNCT03088384 · Klarisana Physician Services PLLC | Completed | N/A | 1 |
| Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and SuicideNCT03666390 · Taipei Veterans General Hospital, Taiwan | Unknown status | Not applicable | 1 |
| Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine AbusersNCT03644719 · National Taiwan University | Completed | Not applicable | — |
| Ketamine Anesthesia for Improvement of Depression in ECTNCT02752724 · VA Puget Sound Health Care System | Completed | Not applicable | 1 |
| Physiological and Cognitive Biomarkers for Ketamine's Antidepressant EffectsNCT02669043 · Massachusetts General Hospital | Terminated | Not applicable | 1 |
| Respiratory Depression During an Analgosedation Combining Remifentanil and Ketamine in TCI for Oocyte RetrievalNCT03458143 · Erasme University Hospital | Unknown status | N/A | 1 |
| Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive DisorderNCT01613820 · Massachusetts General Hospital | Withdrawn | Not applicable | 1 |
| Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive SymptomsNCT02422303 · The University of Texas Health Science Center at San Antonio | Terminated | Not applicable | 1 |
| Prospective Analgesic Compound Efficacy (PACE) StudyNCT02403687 · Express Specialty Pharmacy | Completed | N/A | — |
| Treatment of Suicidal Ideation With Intravenous Ketamine InfusionNCT01887990 · University of Alabama at Birmingham | Completed | Not applicable | 1 |
| PET Imaging of mGLuR5 With Drug ChallengeNCT01691092 · Yale University | Completed | Not applicable | 3 |
| Ketamine Infusion for Treatment-resistant Major Depressive DisorderNCT01582945 · Massachusetts General Hospital | Completed | Not applicable | 1 |
| Ketamine Versus Placebo for Treatment Resistant Major Depressive DisorderNCT01667926 · Massachusetts General Hospital | Completed | Not applicable | 1 |
| MRI Studies of Emotion in DepressionNCT02429011 · Icahn School of Medicine at Mount Sinai | Completed | N/A | 1 |
| Intranasal Ketamine in Treatment-Resistant DepressionNCT01304147 · James Murrough | Completed | Not applicable | 1 |
| TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSDNCT02766192 · The Cooper Health System | Unknown status | Not applicable | 1 |
| Ketamine Use in Electroconvulsive TherapyNCT02012335 · Hospital de Clinicas de Porto Alegre | Withdrawn | Not applicable | 1 |
| Ketamine for Acute Suicidal Ideation in the Emergency Department: Randomized Controlled TrialNCT01892995 · Brooke Army Medical Center | Unknown status | Not applicable | 1 |
| Ketamine Infusions for Major Depression DisorderNCT02219867 · Sheba Medical Center | Unknown status | Not applicable | 1 |
| Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in DepressionNCT01309581 · James Murrough | Terminated | Not applicable | 1 |
| Ketamine Anesthesia in Electroconvulsive TherapyNCT01367119 · Mayo Clinic | Completed | Not applicable | 1 |
| Neuromodulation to Facilitate the Effect of KetamineNCT01816958 · The Neuroscience Center, LLC | Completed | N/A | 1 |