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CompletedNot applicable

Outcome of Multimodal Anesthesia Bern

NCT06985069 · Insel Gruppe AG, University Hospital Bern

Closed to entry
Status
Not accepting participants
Not applicable
Phase
240
Target enrolment
1
Study sites
Outside the US

What it is testing

Summary

In the context of the ongoing opioid crisis in the USA and Europe, reducing perioperative opioid use is a growing priority. Multimodal anesthesia (MMA) offers a patient-centered alternative to opioid-free anesthesia, combining regional techniques, non-opioid analgesics, and adjunct therapies to enhance pain control while minimizing opioid reliance. By targeting multiple pain pathways, MMA can improve recovery outcomes, reduce side effects, and optimize resource use, representing a potential paradigm shift in perioperative medicine. This study compares (patient-centered) outcomes after application of MMA (a standardized combination of Magnesium, Ketamine, Lidocain and Dexmedetomidine before and during surgery in combination with opioids) with an opioid based general anesthesia regimen in the context of major surgery.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Patient centered satisfaction measured by the QoR-15 (Quality of Recovery-15 questionnaire with 15 questions)

    Measured over Postoperative day 1

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years
Ages
All
Sex
Accepted
Healthy volunteers
Inclusion Criteria: * Existing informed consent * German, Italian or French speaking * Age 18 or more * Planned duration of surgery 60min or more * Inpatients and postoperative transfer to PACU or 24h ICU Exclusion Criteria: * Palliative or emergency procedures * Reoperation (e.g. 2nd look) * Bariatric surgery patients * Pregnancy / breastfeeding * Adults legally protected * Known allergy or contraindication to interventional medication

Where

1 study site

FacilityCityRegionCountry
Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University HospitalBern—Switzerland

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT06985069 on ClinicalTrials.gov →

Last updated in the registry 2025-11-18. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

All 2 trials from Insel Gruppe AG, University Hospital Bern →