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Unknown statusPhase 4

Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression

NCT02924090 · University of Manitoba

Closed to entry
Status
Not accepting participants
Phase 4
Phase
48
Target enrolment
1
Study sites
Outside the US

What it is testing

Summary

This is a randomized controlled study assessing the effect of pre-emptive hyperventilation on ECT seizure duration, cerebral desaturation and remission of depressive symptoms in patients with Major Depressive Disorder. Comparison of etomidate and ketamine on remission of depressive symptoms with and without pre-emptive hyperventilation will also be studied.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • EEG seizure duration (seconds)

    Measured over Up to 3 minutes post ECT

  • ECT-induced seizure duration (seconds)

    Measured over Up to 3 minutes post ECT

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 85 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Adults patients aged 18 to 85 years * Diagnosed with Major Depressive Disorder, unipolar or bipolar depression * Undergoing ECT for treatment of their symptoms * Currently residing in Manitoba Exclusion Criteria: * Relative contraindications to ECT therapy (recent MI or CVA, increased intracranial pressure, intracranial mass lesion, intracranial aneurysm, epilepsy, known cardiac arrhythmia, pheochromocytoma, pregnancy) * Contraindications to etomidate (sepsis, primary or secondary adrenal insufficiency, porphyria) * DSM-V diagnosis of a lifetime history of psychotic spectrum disorder * Drug or alcohol dependence, or abuse within the past 3 months, soy-bean oil allergy

Where

1 study site

FacilityCityRegionCountry
Health Sciences CentreWinnipegManitobaCanada

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT02924090 on ClinicalTrials.gov →

Last updated in the registry 2016-10-21. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

Indication