Modified Ketogenic Diet and Ketamine for Anorexia Nervosa

Inclusion Criteria: * Adults Between 18 and 65 * Anorexia Nervosa Diagnosis For at Least 3 Years * Treatment Resistance, as Evidenced by Having Failed at Least 2 Treatments * Body Mass Index (BMI) Greater than or Equal to 18.5 * Stable Weight for the Last 3 Months (No Consistent Change Greater than 5 Pounds) * Abstinence From Substance Abuse for At Least 3 Months * No Cannabis Use for At Least 3 Months * Currently Under the Care of a Primary Care Provider (PCP) * Participant Must Agree to have PCP Contacted by Study Staff * Willingness to Participant in a 2-Day Program in Central Connecticut * Identified Support Partner Who Will Attend Program * Willingness to Have Weight Recorded and Reported by PCP or Support Partner * Willingness to Attend 4-6 Clinic Visits For Ketamine Infusion * Willingness to Be Contacted for Follow Up for 12 Months * Willingness to Abide By All COVID Safety Measures Exclusion Criteria * Concomitant Disease (Gastroentestinal, Renal, Respiratory, Cardiac, Etc) or Any Clinically Significant Finding at Screening that Would Pose a Risk to the Participant * Primary Carnitine Deficiency, Beta Oxidation Defects, Pyruvate Carboxylase Deficiency, Porphyria, or Treatment with Carbonic Anhydrase Inhibitors * Bulimia Nervosa as The Primary Diagnosis * Weight Change of Greater Than 5 Pounds in Last 3 Months * Pregnancy * Sexually Active Females Not Using Birth Control * Interstitial Cystitis * Unmanaged/Unstable Hypertenison (Greater than 140 Systolic; 90 Diastolic * Cardiac Arrythmia * Uncontrolled Seizure Disorder or Seizure Withen 30 Days Prior to Screening * QTc Interval of 470 ms or Greater * Current or Past History of Psychotic Disorder * Active Suicidal Ideation * Enrolled in any Clinical Trial or Used Any Investigational Agent, Device, and/or Investigational Procedure Within 30 Days Before Screening, or Does so Concurrently With this Study