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Unknown statusPhase 2

Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican Population

NCT01868802 · Paul J. Lamothe

Closed to entry
Status
Not accepting participants
Phase 2
Phase
60
Target enrolment
1
Study sites
Outside the US

What it is testing

Summary

A randomized multicentric parallel arms study involving the use of ketamine for treatment-resistant depression will be held at three national health provider clinics in the Mexican population. The purpose of this study is to determine whether clinical response seen in previous studies is replicable in this population.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Changes in baseline HDRS Score

    Measured over 20 minutes before and 40 minutes after ketamine infusion.

  • Daily change in HDRS post-ketamine infusion.

    Measured over 1,2,3,4,5,6 and 7. Days after ketamine infusion

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 65 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Age: 18-65 years old * Mayor Depressive Disorder Diagnosis based on DSM-IV TR. * Classification of MDD as treatment-resistant. * No brain structural abnormalities as evidenced by an MRI scan. * Signed acceptance of Informed Consent. Exclusion Criteria: * Other psychiatric diagnosis apart from MDD. * Substance abuse or dependence (prior or during study). * Pregnancy. * Congestive heart disease. * Personal history of psychosis. * First-degree relative with history of psychosis. * Glaucoma. * Present neurological disease. * High blood or pulmonary artery pressure. * Declining the signing of the informed consent.

Where

1 study site

FacilityCityRegionCountry
ABC Neurological CenterMexico CityMexico CityMexico

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT01868802 on ClinicalTrials.gov →

Last updated in the registry 2015-03-17. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance