Effect of Esketamine on Reducing Postoperative Anxiety and Depression in Adolescent Patients

Inclusion Criteria: 1. 8 years ≤ age ≤17 years; 2. Patients who plan to undergo elective surgery under general anesthesia, and the operation time is ≥2h; 3. ASA grade I-II Exclusion Criteria: 1. Patients expected to be admitted to ICU after surgery; 2. Patients who need to return to the ward with tracheal intubation after surgery; 3. Allergic to the active ingredients or excipients of isketamine hydrochloride injection; 4. Patients with severe consciousness disorder or mental system disease (schizophrenia, mania, bipolar disorder, psychosis, etc.) or cognitive dysfunction; 5. Patients with congenital heart disease and severe developmental delay; 6. Patients with one of the following contraindications to esketamine :(a) patients at risk of a significant increase in blood pressure or intracranial pressure; (b) Patients with ocular hypertension (glaucoma) or penetrating ocular trauma; (c) Patients with poorly controlled or untreated hypertension (resting systolic blood pressure greater than 180 mmHg or resting diastolic blood pressure greater than 100 mmHg); (d) Untreated or undertreated hyperthyroidism; 7. Previous history of ketamine abuse or dependence, drug or alcohol dependence for more than 6 months, previous ketamine ineffective tests or adverse reactions.