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Intravenous Esketamine on Prevention of Postoperative Depression in Patients Undergoing Cardiac Surgery

NCT05155969 · Anshi Wu

Closed to entry
Status
Not accepting participants
Not applicable
Phase
80
Target enrolment
2
Study sites
Outside the US

What it is testing

Summary

Esketamine is a general anesthetic with anti-depressant effects at subanaesthetic doses. This study hypothesized that intraoperative administration of ketamine would prevent or mitigate postoperative depressive symptoms in surgical patients.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Response rate

    Measured over Postoperative 5 Days

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * 1:Patients scheduled for heart surgery * 2:Moderate to severe depressive symptom measured by the qualified psychiatric doctors * 3:Over 18 years of age * 4:American Society of Anesthesiologists physical status I-III Exclusion Criteria: * 1:History of epilepsy * 2:Major depression disorder patients undergoing antidepressive therapy within 2 weeks * 3: Psychiatric illness * 4: Drug abuse * 5:History of allergy to esketamine * 6:Hyperthyroidism * 7:Patients can not cooperate with investigators on psychiatric assessments * 8:Pregnant or breastfeeding woman * 9:refuse to sign informed consent.

Where

2 study sites

FacilityCityRegionCountry
Beijing Chaoyang Hospital, Capital Medical UniversityBeijingBeijing MunicipalityChina
Beijing Chaoyang HospitalBeijingBeijing MunicipalityChina

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT05155969 on ClinicalTrials.gov →

Last updated in the registry 2021-12-14. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance