Indication

Obsessive-Compulsive Disorder

28 registered trials testing LSD, Psilocybin, MDMA, Ketamine, DMT for this indication, 9 recruiting now.

Sponsors register this under 6 different names, all collected here: OCD · Obsessive - Compulsive Disorder · Obsessive Compulsive Disorder · Obsessive-Compulsive Disorder · Obsessive-compulsive Disorder · Obsessive-compulsive Disorder (OCD)

Registered trials

Recruiting

In Phase 3

Substances tested

Being studied with

Stay told

When a new trial opens

Trials

All 28 trials for Obsessive-Compulsive Disorder

Trial	Status	Phase	Substance	Sites
Pilot Study of RR-HNK in OCDNCT06575075 · Carolyn Rodriguez	Recruiting	Phase 1 / Phase 2	ketamine	1
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)NCT05940324 · Stanford University	Recruiting	Phase 2	ketamine	1
MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)NCT05783817 · Carolyn Rodriguez	Recruiting	Phase 2	mdma	1
Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCDNCT04882839 · Beersheva Mental Health Center	Recruiting	Phase 2	psilocybin	1
Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.NCT07347405 · Francisco A Moreno	Recruiting	Phase 1	psilocybin	1
Open-Label Psilocybin Study in Transdiagnostic PopulationNCT06442423 · Yale University	Recruiting	Phase 1	psilocybin	1
Retrospective Analyses of the Greenbrook Database Evaluating Mental Health TreatmentsNCT06997549 · Neuronetics	Recruiting	N/A	ketamine	1
University of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · Mark Niciu	Recruiting	N/A	ketamine	1
Ketamine in OCD: Efficacy and Effects on Stress and CognitionNCT05577585 · Medical University of Vienna	Recruiting	Not applicable	ketamine	1
Understanding How Ketamine Brings About Rapid Improvement in OCDNCT02624596 · Stanford University	Completed	Phase 2	ketamine	1
Psilocybin for Treatment of OCD-2NCT06992999 · Francisco A Moreno	Not yet recruiting	Phase 1 / Phase 2	psilocybin	1
Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)NCT02422290 · New York State Psychiatric Institute	Completed	Phase 1 / Phase 2	ketamine	1
Intravenous Ketamine in the Treatment of Obsessive-Compulsive DisorderNCT01371110 · Wayne Goodman MD	Terminated	Phase 1 / Phase 2	ketamine	1
Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive DisorderNCT00956085 · New York State Psychiatric Institute	Completed	Phase 2	ketamine	1
A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive DisorderNCT02234011 · Mclean Hospital	Terminated	Phase 2	ketamine	1
Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With OCDNCT02206776 · New York State Psychiatric Institute	Terminated	Phase 2	ketamine	1
Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD)NCT01100255 · New York State Psychiatric Institute	Completed	Phase 2	ketamine	1
Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)NCT02062658 · New York State Psychiatric Institute	Completed	Phase 2	ketamine	1
Ketamine Infusion for Obsessive-Compulsive DisorderNCT01349231 · Yale University	Completed	Phase 2	ketamine	1
Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCDNCT06299319 · Centre for Addiction and Mental Health	Active, not recruiting	Phase 1	psilocybin	1
Effects of Repeated Psilocybin Dosing in OCDNCT05370911 · Yale University	Active, not recruiting	Phase 1	psilocybin	2
Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.NCT03356483 · Yale University	Completed	Phase 1	psilocybin	1
PsilOCD: A Pharmacological-Challenge Feasibility StudyNCT06258031 · Imperial College London	Completed	Phase 1	psilocybin	1
Psilocybin for Treatment of Obsessive Compulsive DisorderNCT03300947 · University of Arizona	Completed	Phase 1	psilocybin	1
Effects of Psilocybin in Obsessive Compulsive DisorderNCT05546658 · Johns Hopkins University	Active, not recruiting	Early Phase 1	psilocybin	1
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic PsychedelicsNCT06624137 · Yale University	Terminated	N/A	lsd, psilocybin, dmt	2
Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)NCT05565352 · Medical University of Gdansk	Enrolling by invitation	N/A	ketamine	1
Chart Review of Patients Undergoing Ketamine InfusionsNCT04209296 · Brain and Cognition Discovery Foundation	Completed	N/A	ketamine	1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.