| Positioning of Esketamine Treatment in the Real-world Management of DepressionNCT06103760 · Royal North Shore Hospital | Recruiting | Phase 4 | ketamine | 1 |
| Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With DepressionNCT05450432 · Massachusetts General Hospital | Recruiting | Phase 4 | ketamine | 1 |
| Neural Circuit Effects of Ketamine in DepressionNCT06213324 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 4 | ketamine | 1 |
| A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited | Recruiting | Phase 3 | psilocybin | 68 |
| The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive DisorderNCT06247839 · Sharmin Ghaznavi | Recruiting | Phase 3 | psilocybin | 1 |
| A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc. | Recruiting | Phase 3 | lsd | 30 |
| A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive DisorderNCT07227454 · Janssen Research & Development, LLC | Recruiting | Phase 3 | ketamine | 35 |
| Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive DisorderNCT07703722 · Khyber Medical University Peshawar | Recruiting | Phase 3 | psilocybin | 3 |
| Understanding and Treating Suicidal Ideation With KetamineNCT06891300 · The Royal's Institute of Mental Health Research | Recruiting | Phase 2 / Phase 3 | ketamine | 1 |
| Ketamine Augmentation of ECT in Treatment-Resistant DepressionNCT07088380 · Università Vita-Salute San Raffaele | Recruiting | Phase 3 | ketamine | 1 |
| Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureNCT05603104 · Dr. Inge Winter | Recruiting | Phase 3 | ketamine | 1 |
| The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.NCT05973851 · Dr. Inge Winter | Recruiting | Phase 3 | ketamine | 12 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)NCT07569198 · Joshua Rosenblat | Recruiting | Phase 2 | ketamine | 1 |
| A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and AnxietyNCT06820723 · Ohio State University | Recruiting | Phase 2 | psilocybin | 1 |
| Inhaled DMT for Major Depressive DisorderNCT07562191 · Universidade Federal do Rio Grande do Norte | Recruiting | Phase 2 | dmt | 5 |
| Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionNCT06511908 · National Institute of Mental Health (NIMH) | Recruiting | Phase 2 | ketamine | 1 |
| Psilocybin Therapy for Psychological Distress in Palliative PatientsNCT06782724 · University Medical Center Groningen | Recruiting | Phase 2 | psilocybin | 4 |
| The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsNCT05786066 · Yale University | Recruiting | Phase 2 | ketamine | 1 |
| Cancer Related Major Depression Treated With a Single Dose of PsilocybinNCT06319378 · Section for Affective Disorders; Northern Stockholm Psychiatry | Recruiting | Phase 2 | psilocybin | 4 |
| A Randomized Neuroimaging Trial of Psilocybin in DepressionNCT06072898 · Sunnybrook Health Sciences Centre | Recruiting | Phase 2 | psilocybin | 1 |
| Imaging Depression in Parkinson's DiseaseNCT06402955 · Yale University | Recruiting | Phase 2 | ketamine | 1 |
| A Study to Evaluate the Efficacy, Safety, and Pharmacokinetic Characteristics of (R)-Ketamine Hydrochloride Nasal Spray in Patients With Depression and Acute Suicidal Ideation or BehaviorNCT07193901 · Sichuan Purity Pharmaceutical Technology Co., Ltd. | Recruiting | Phase 2 | ketamine | 8 |
| i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical TrialNCT06480500 · University Health Network, Toronto | Recruiting | Phase 2 | ketamine | 1 |
| Psilocybin rTMS for Treatment Resistant DepressionNCT06132178 · University of Texas at Austin | Recruiting | Phase 2 | psilocybin | 1 |
| Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of DepressionNCT06559826 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 2 | ketamine | 1 |
| Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive DisorderNCT06592833 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 2 | psilocybin | 1 |
| Pharmacologic Treatment Augmentation in Chronic DepressionNCT06410599 · University Hospital Tuebingen | Recruiting | Phase 2 | ketamine | 2 |
| Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderNCT03065335 · National Institute of Mental Health (NIMH) | Recruiting | Phase 1 | ketamine | 1 |
| Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant DepressionNCT06480201 · Texas A&M University | Recruiting | Phase 1 | ketamine | 2 |
| Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionNCT03973268 · National Institute of Mental Health (NIMH) | Recruiting | Phase 1 | ketamine | 1 |
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine ResponseNCT05915013 · Yale University | Recruiting | Phase 1 | ketamine | 1 |
| Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of KetamineNCT06788249 · University of Pennsylvania | Recruiting | Early Phase 1 | ketamine | 1 |
| Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With KetamineNCT05327699 · Emory University | Recruiting | Early Phase 1 | ketamine | 1 |
| Antidepressant Response of DMT Masked With PropofolNCT06927076 · University Hospital, Basel, Switzerland | Recruiting | Not applicable | dmt | 1 |
| University of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · Mark Niciu | Recruiting | N/A | ketamine | 1 |
| At-Home tDCS as Maintenance TherapyNCT07269964 · Technical University of Munich | Recruiting | Not applicable | ketamine | 2 |
| Metabolic Profiling of Esketamine Treatment in Depressive DisorderNCT07002684 · University of Zagreb | Recruiting | N/A | ketamine | 1 |
| Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot StudyNCT06732089 · Unity Health Toronto | Recruiting | N/A | ketamine | 1 |
| RIVER At Home Ketamine ProtocolsNCT06070766 · RIVER Foundation | Recruiting | N/A | ketamine | 2 |
| Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal ThoughtsNCT07139106 · New York State Psychiatric Institute | Not yet recruiting | Phase 4 | ketamine | 1 |
| Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for DepressionNCT05615948 · Theresa Jacob, PhD, MPH | Completed | Phase 4 | ketamine | 1 |
| A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray TreatmentNCT04829318 · Janssen-Cilag Ltd. | Completed | Phase 4 | ketamine | 59 |
| Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant DepressionNCT05045378 · Taipei Veterans General Hospital, Taiwan | Completed | Phase 4 | ketamine | 1 |
| Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot StudyNCT05950711 · Ohio State University | Active, not recruiting | Phase 4 | ketamine | 1 |
| VA Aripiprazole vs Esketamine for Treatment Resistant DepressionNCT05554627 · VA Office of Research and Development | Withdrawn | Phase 4 | ketamine | 26 |
| Ketamine Treatment Effects on Synaptic Plasticity in DepressionNCT04091971 · New York State Psychiatric Institute | Completed | Phase 4 | ketamine | 1 |
| Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac SurgeryNCT03861988 · Stanford University | Completed | Phase 4 | ketamine | 1 |
| An EEG Study of Intravenous Ketamine for Major Depression DisorderNCT05506462 · Ehave Inc. | Unknown status | Phase 4 | ketamine | — |
| Intra-nasal vs. Intra-venous Ketamine AdministrationNCT02644629 · Shalvata Mental Health Center | Completed | Phase 4 | ketamine | 1 |
| Ketamine Infusion for Adolescent Depression and AnxietyNCT02579928 · Yale University | Completed | Phase 4 | ketamine | 2 |
| Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)NCT04352621 · University of Cincinnati | Unknown status | Phase 4 | ketamine | — |
| Ketamine in the Treatment of Suicidal DepressionNCT01700829 · New York State Psychiatric Institute | Completed | Phase 4 | ketamine | 1 |
| Ketamine for Depression: An MRI StudyNCT02544607 · Massachusetts General Hospital | Completed | Phase 4 | ketamine | 1 |
| N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major DepressionNCT01260649 · Massachusetts General Hospital | Terminated | Phase 4 | ketamine | 1 |
| "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"NCT06564818 · Cybin IRL Limited | Active, not recruiting | Phase 3 | psilocybin | 45 |
| A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)NCT06941844 · Definium Therapeutics US, Inc. | Active, not recruiting | Phase 3 | lsd | 22 |
| Psilocybin for Major Depressive Disorder (MDD)NCT06308653 · Usona Institute | Active, not recruiting | Phase 3 | psilocybin | 29 |
| Opiate Suicide Study in Patients With Major DepressionNCT04116528 · Stanford University | Completed | Phase 3 | ketamine | 1 |
| Predictors of Intravenous Ketamine Response in TRDNCT05625555 · Abraham Nunes | Active, not recruiting | Phase 3 | ketamine | 1 |
| 54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03039192 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 56 |
| 54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03097133 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 61 |
| A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive DisorderNCT04338321 · Janssen-Cilag International NV | Completed | Phase 3 | ketamine | 171 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)NCT03113968 · Bo Hu | Completed | Phase 2 / Phase 3 | ketamine | 5 |
| Ketamine Versus Electroconvulsive Therapy in DepressionNCT03674671 · University of Ottawa | Suspended | Phase 3 | ketamine | 4 |
| Ketamine for Severe Adolescent Depression: Intermediate-term Safety and EfficacyNCT03889756 · Yale University | Terminated | Phase 2 / Phase 3 | ketamine | 1 |
| ECT vs. EsketamineNCT04924257 · Medical University Innsbruck | Withdrawn | Phase 3 | ketamine | 1 |
| The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major DepressionNCT02037503 · Tel-Aviv Sourasky Medical Center | Unknown status | Phase 3 | ketamine | 1 |
| Endogenous Opioid Modulation by KetamineNCT03051945 · University of Utah | Withdrawn | Phase 3 | ketamine | 1 |
| Ketamine as an Alternative Treatment to ECT in Major Depressive DisorderNCT02659085 · Pouya Movahed Rad | Completed | Phase 2 / Phase 3 | ketamine | 1 |
| Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six WeeksNCT01557712 · University Hospital, Grenoble | Completed | Phase 3 | ketamine | 1 |
| An Open Prospective Trial of IV Ketamine in Suicidal AdolescentsNCT02048423 · Nationwide Children's Hospital | Unknown status | Phase 2 / Phase 3 | ketamine | 1 |
| Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of PsilocybinNCT06341426 · University Health Network, Toronto | Active, not recruiting | Phase 2 | psilocybin | 2 |
| A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major DepressionNCT07396272 · Daniel Lindqvist | Active, not recruiting | Phase 2 | ketamine | 1 |
| Psilocybin for Treatment-Resistant DepressionNCT06230757 · University of Colorado, Denver | Completed | Phase 2 | psilocybin | 1 |
| Two Doses of Psilocybin for the Treatment of MDD in Adults With CancerNCT05947383 · Sunstone Medical | Active, not recruiting | Phase 2 | psilocybin | 1 |
| A Study of Psilocybin for Major Depressive Disorder (MDD)NCT03866174 · Usona Institute | Completed | Phase 2 | psilocybin | 11 |
| Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use DisorderNCT04620759 · Johns Hopkins University | Active, not recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use DisorderNCT07405606 · Centre for Addiction and Mental Health | Not yet recruiting | Phase 2 | psilocybin | 1 |
| Microdosing Psychedelics to Improve MoodNCT05259943 · Rotem Petranker | Completed | Phase 2 | psilocybin | 1 |
| Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality DisorderNCT05399498 · University of Chicago | Completed | Phase 2 | psilocybin | 1 |
| Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL)NCT07247370 · South West Sydney Local Health District | Not yet recruiting | Phase 1 / Phase 2 | ketamine | 1 |
| Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electrical Activity MarkersNCT06746441 · Khyber Medical University Peshawar | Completed | Phase 2 | psilocybin | 1 |
| A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive DisorderNCT05733546 · COMPASS Pathways | Active, not recruiting | Phase 2 | psilocybin | 5 |
| Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic TargetsNCT05046184 · University of Texas Southwestern Medical Center | Completed | Phase 2 | ketamine | 1 |
| A Study of Ketamine in Patients With Treatment-resistant DepressionNCT01627782 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 13 |
| A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant DepressionNCT01640080 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 9 |
| A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for SuicideNCT02133001 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 14 |
| Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for SuicideNCT03185819 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 51 |
| LSD Therapy for Persons Suffering From Major DepressionNCT03866252 · University Hospital, Basel, Switzerland | Completed | Phase 2 | lsd | 1 |
| Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderNCT02461927 · VA Office of Research and Development | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative MechanismsNCT03429075 · Imperial College London | Completed | Phase 2 | psilocybin | 1 |
| Psilocybin for Major Depressive DisorderNCT05675800 · Washington University School of Medicine | Withdrawn | Phase 2 | psilocybin | — |
| KAP for Depression in Abstinent Opioid UsersNCT05193318 · Medical University of South Carolina | Terminated | Phase 2 | ketamine | 1 |
| The Effect of Psilocybin on MDD Symptom Severity and Synaptic DensityNCT04630964 · Section for Affective Disorders; Northern Stockholm Psychiatry | Completed | Phase 2 | psilocybin | 1 |
| SPL026 (DMT Fumarate) in Healthy Subjects and MDD PatientsNCT04673383 · Small Pharma Ltd | Completed | Phase 1 / Phase 2 | dmt | 2 |
| A Study of a Psilocybin Analog (CYB003) in Healthy Participants With and Without Major Depressive DisorderNCT05385783 · Cybin IRL Limited | Completed | Phase 1 / Phase 2 | psilocybin | 3 |
| Ketamine Treatment for PTSD and MDD in TBINCT06228391 · Minneapolis Veterans Affairs Medical Center | Not yet recruiting | Phase 2 | ketamine | 1 |
| Ketamine or Placebo in Patients With Major Depression and Advanced CancerNCT04471818 · Instituto Nacional de Cancerologia de Mexico | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of SuicideNCT04669665 · Seelos Therapeutics, Inc. | Completed | Phase 2 | ketamine | 21 |
| Open Label Ketamine Treatment for Major Depressive Disorder in VeteransNCT03053830 · VA Connecticut Healthcare System | Completed | Phase 2 | ketamine | 1 |
| Clinical Study of GH001 in DepressionNCT04698603 · GH Research Ireland Limited | Completed | Phase 1 / Phase 2 | dmt | 1 |
| Effect of SSRIs on Response to Psilocybin TherapyNCT05594667 · Cybin Therapeutics Inc. | Withdrawn | Phase 2 | psilocybin | 1 |
| PET Synaptogenesis After Psilocybin In DEpression RecoveryNCT05601648 · Washington University School of Medicine | Withdrawn | Phase 2 | psilocybin | 1 |
| miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment OutcomeNCT02418195 · University of Alabama at Birmingham | Completed | Phase 2 | ketamine | 1 |
| Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of ConceptNCT03715127 · University of Zurich | Completed | Phase 2 | psilocybin | 1 |
| Effects of Psilocybin in Major Depressive DisorderNCT03181529 · Johns Hopkins University | Completed | Phase 2 | psilocybin | 1 |
| The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive DisorderNCT04593563 · Maryland Oncology Hematology, PA | Unknown status | Phase 2 | psilocybin | 1 |
| The UTHealth Ketamine ProjectNCT02882711 · The University of Texas Health Science Center, Houston | Terminated | Phase 2 | ketamine | 1 |
| Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant DepressionNCT03965858 · Celon Pharma SA | Completed | Phase 2 | ketamine | 12 |
| Ketamine in Adolescents With Treatment-Resistant DepressionNCT02078817 · University of Minnesota | Completed | Phase 2 | ketamine | 1 |
| Ketamine in the Treatment of DepressionNCT01558063 · Columbia University | Completed | Phase 2 | ketamine | 1 |
| Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderNCT03658330 · VA Connecticut Healthcare System | Completed | Phase 2 | ketamine | — |
| A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive DisorderNCT01957410 · Janssen Research & Development, LLC | Terminated | Phase 2 | ketamine | 1 |
| Optimization of IV Ketamine for Treatment Resistant DepressionNCT00768430 · Baylor College of Medicine | Completed | Phase 2 | ketamine | 2 |
| Study of Ketamine as an Antidepressant in Major Depressive DisorderNCT01573741 · Shi Jinyun | Unknown status | Phase 1 / Phase 2 | ketamine | 1 |
| Psilocybin-assisted CBT for DepressionNCT05227612 · University of California, Los Angeles | Completed | Phase 1 | psilocybin | 1 |
| Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive DisorderNCT03554174 · Yale University | Active, not recruiting | Phase 1 | psilocybin | 1 |
| Fixed Order, Open-Label, Dose-Escalation Study of DMT in HumansNCT04711915 · Yale University | Active, not recruiting | Phase 1 | dmt | 1 |
| Repeated Ketamine Infusions for Comorbid PTSD and MDD in VeteransNCT04032301 · University of Minnesota | Completed | Phase 1 | ketamine | 1 |
| A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive DisorderNCT02919579 · Janssen Research & Development, LLC | Completed | Phase 1 | ketamine | 1 |
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot TrialNCT03367533 · Yale University | Completed | Phase 1 | ketamine | 1 |
| SPL026 With or Without SSRIs in Participants With MDDNCT05553691 · Small Pharma Ltd | Completed | Phase 1 | dmt | 2 |
| Phase 1 Evaluation of (2R,6R)-HydroxynorketamineNCT04711005 · National Institute of Mental Health (NIMH) | Completed | Phase 1 | ketamine | 1 |
| The Effect of Ketamine on Aesthetics and Role for Antidepressant EffectsNCT05320107 · Medical University of Vienna | Unknown status | Phase 1 | ketamine | 1 |
| IM and IV SPL026 Drug Product in Healthy ParticipantsNCT05644093 · Small Pharma Ltd | Completed | Phase 1 | dmt | 1 |
| Imaging Neural Correlates of Ketamine Using PET/MRNCT04587778 · Medical University of Vienna | Unknown status | Phase 1 | ketamine | 1 |
| The Role of HNKs in the Antidepressant Effect of KetamineNCT03977675 · Columbia University | Terminated | Phase 1 | ketamine | 1 |
| Ketamine for Relapse Prevention in Recurrent Depressive DisorderNCT02661061 · St Patrick's Hospital, Ireland | Terminated | Phase 1 | ketamine | 1 |
| Biomarkers of Fast Acting Therapies in Major DepressionNCT02165449 · University of California, Los Angeles | Completed | Phase 1 | ketamine | 1 |
| Ketamine for Major Depressive DisorderNCT03721900 · Shenox Pharmaceuticals, LLC | Unknown status | Phase 1 | ketamine | 3 |
| Continuation Ketamine in Major DepressionNCT00548964 · James Murrough | Completed | Phase 1 | ketamine | 1 |
| Mood Effects of Serotonin Agonists: DepressionNCT07017478 · University of Chicago | Completed | Early Phase 1 | lsd | 1 |
| Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:NCT03573349 · Mayo Clinic | Active, not recruiting | Early Phase 1 | ketamine | 1 |
| Ketamine for Mood Disorders With Suicidal IdeationNCT04099771 · The Miriam Hospital | Unknown status | Early Phase 1 | ketamine | 1 |
| A Multimodal Neuroimaging Study of Brain Activation Patterns Under KetamineNCT03609190 · Psychiatric University Hospital, Zurich | Completed | Early Phase 1 | ketamine | — |
| Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.NCT02593643 · Sunnybrook Health Sciences Centre | Completed | Early Phase 1 | ketamine | 1 |
| Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic PsychedelicsNCT06624137 · Yale University | Terminated | N/A | lsd, psilocybin, dmt | 2 |
| Imaging SV2A in Mood DisordersNCT02734602 · Yale University | Active, not recruiting | Not applicable | ketamine | 1 |
| Multimodal Pharmacological Study of Clinical Cohorts for Major Depressive DisorderNCT07602153 · Shanghai Mental Health Center | Not yet recruiting | N/A | ketamine | — |
| PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive DisorderNCT04353921 · Usona Institute | Terminated | N/A | psilocybin | 1 |
| Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive DisorderNCT07526454 · Tanta University | Completed | Not applicable | ketamine | 1 |
| Mitochondrial Function After KetamineNCT07399756 · Sheba Medical Center | Not yet recruiting | N/A | ketamine | 1 |
| Comparison of Propofol and Ketofol as Induction Agents for Electroconvulsive TherapyNCT07273851 · Fauji Foundation Hospital | Completed | Not applicable | ketamine | 1 |
| Retrospective Observational Study of Intensity Effects in Psychedelic-assisted TreatmentNCT07164287 · University Hospital, Geneva | Active, not recruiting | N/A | lsd, psilocybin | 1 |
| Behavioural Activation Therapy and Esketamine for Resistant DepressionNCT06431386 · The Royal's Institute of Mental Health Research | Terminated | Not applicable | ketamine | 1 |
| Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)NCT05565352 · Medical University of Gdansk | Enrolling by invitation | N/A | ketamine | 1 |
| Synaptic Imaging and Network Activity in Treatment Resistant DepressionNCT05870501 · King's College London | Completed | Not applicable | ketamine | 1 |
| Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant DepressionNCT04239963 · Mclean Hospital | Completed | N/A | ketamine | 1 |
| Brain Network Dynamics of Depression During Esketamine TreatmentNCT06012916 · University of North Carolina, Chapel Hill | Completed | N/A | ketamine | 1 |
| Chart Review of Patients Undergoing Ketamine InfusionsNCT04209296 · Brain and Cognition Discovery Foundation | Completed | N/A | ketamine | 1 |
| Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant DepressionNCT06232291 · Medical University of Gdansk | Completed | N/A | ketamine | 1 |
| Glutamate Emotion Memory StudyNCT05809609 · University of Oxford | Unknown status | Not applicable | ketamine | 1 |
| A Naturalistic Study of Ketamine for Treatment Resistant Mood DisordersNCT04226963 · Medical University of Gdansk | Completed | N/A | ketamine | 1 |
| Naturalistic Study of Ketamine in the Treatment of DepressionNCT05249309 · Hospital de Clinicas de Porto Alegre | Unknown status | N/A | ketamine | 2 |
| Reward Emotion Learning and Ketamine StudyNCT04850911 · University of Oxford | Unknown status | Not applicable | ketamine | 1 |
| Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in DepressionNCT04701866 · Douglas Mental Health University Institute | Completed | Not applicable | ketamine | 2 |
| Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine SprayNCT04843462 · Lukas Pezawas | Unknown status | Not applicable | ketamine | 1 |
| Esketamine Adjuvant Therapy for Patients With Chronic Visceral Pain Comorbid Major Depressive DisorderNCT04847245 · Peking University | Unknown status | Not applicable | ketamine | — |
| Ketamine IV Classic Protocol : Five Years Follow upNCT04824157 · Sheba Medical Center | Completed | N/A | ketamine | 1 |
| The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)NCT04399070 · Yan Qiu | Unknown status | Not applicable | ketamine | 1 |
| Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant DepressionNCT03027362 · Yale University | Completed | Not applicable | ketamine | 1 |
| Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant DepressionNCT02522377 · The Cleveland Clinic | Completed | Not applicable | ketamine | 1 |
| Ketamine for Treatment Resistant MDDNCT04021433 · Hadassah Medical Organization | Unknown status | Not applicable | ketamine | 1 |
| Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and SuicideNCT03666390 · Taipei Veterans General Hospital, Taiwan | Unknown status | Not applicable | ketamine | 1 |
| Ketamine Anesthesia for Improvement of Depression in ECTNCT02752724 · VA Puget Sound Health Care System | Completed | Not applicable | ketamine | 1 |
| Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive DisorderNCT01613820 · Massachusetts General Hospital | Withdrawn | Not applicable | ketamine | 1 |
| Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive SymptomsNCT02422303 · The University of Texas Health Science Center at San Antonio | Terminated | Not applicable | ketamine | 1 |
| PET Imaging of mGLuR5 With Drug ChallengeNCT01691092 · Yale University | Completed | Not applicable | ketamine | 3 |
| Ketamine Infusion for Treatment-resistant Major Depressive DisorderNCT01582945 · Massachusetts General Hospital | Completed | Not applicable | ketamine | 1 |
| Ketamine Versus Placebo for Treatment Resistant Major Depressive DisorderNCT01667926 · Massachusetts General Hospital | Completed | Not applicable | ketamine | 1 |
| MRI Studies of Emotion in DepressionNCT02429011 · Icahn School of Medicine at Mount Sinai | Completed | N/A | ketamine | 1 |
| Intranasal Ketamine in Treatment-Resistant DepressionNCT01304147 · James Murrough | Completed | Not applicable | ketamine | 1 |
| Ketamine Infusions for Major Depression DisorderNCT02219867 · Sheba Medical Center | Unknown status | Not applicable | ketamine | 1 |