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Unknown statusPhase 4

Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy

NCT02305394 · First Affiliated Hospital of Chongqing Medical University

Closed to entry
Status
Not accepting participants
Phase 4
Phase
132
Target enrolment
1
Study sites
Outside the US

What it is testing

Summary

Electroconvulsive therapy (ECT) is an effective treatment for depression compared with the current antidepressant agents，but the most important side effect is cognitive dysfunction. The purpose of this study is to determine whether subanesthetic dose of ketamine combined with propofol is superior to propofol anesthesia alone in improving cognitive function in depressive patients undergoing ECT.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Mini-Mental State examination score

    Measured over at 24 hours after the sixth ECT

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 65 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: 1. diagnosed with moderate or severe depression according to Diagnostic and Statistical Manual of Mental Disorders 2. aged from 18 to 65 years old Exclusion Criteria: 1. cerebrovascular malformation, arterial aneurysm, hypertension, or glaucoma; 2. classification of American Society of Anesthesiologists physical status score IV or V; 3. complications such as respiratory disease, cardiovascular disease, intracranial hypertension, cerebral vascular disorder; 4. presence of a foreign body such as pacemaker, intracranial electrode, and clips; 5. history of seizures; 6. history of drug abuse; 7. concomitant presence of a mental disorder; 8. pregnancy; 9. history of serious adverse effects related to anesthetics; 10. refusal to consent for the study, or refusal to undergo one single ECT during the first week of therapy. 11. hyperthyreosis

Where

1 study site

FacilityCityRegionCountry
China,Chongqing The First Affiliated Hospital of Chongqing Medical UniversityChongqingChongqing MunicipalityChina

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT02305394 on ClinicalTrials.gov →

Last updated in the registry 2014-12-02. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

All 2 trials from First Affiliated Hospital of Chongqing Medical University →