Indication

Bipolar Depression

24 registered trials testing Psilocybin, Ketamine for this indication, 3 recruiting now.

Sponsors register this under 2 different names, all collected here: Bipolar Depression · Depression, Bipolar

Registered trials

Recruiting

In Phase 3

Substances tested

Being studied with

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When a new trial opens

Trials

All 24 trials for Bipolar Depression

Trial	Status	Phase	Substance	Sites
Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureNCT05603104 · Dr. Inge Winter	Recruiting	Phase 3	ketamine	1
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and SuicidalityNCT06706232 · The University of Texas Health Science Center, Houston	Recruiting	Phase 2	psilocybin	1
University of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · Mark Niciu	Recruiting	N/A	ketamine	1
IM Ketamine vs Midazolam for Suicidal ER PatientsNCT04640636 · New York State Psychiatric Institute	Suspended	Phase 4	ketamine	1
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in DepressionNCT01881763 · Northwell Health	Completed	Phase 4	ketamine	1
Ketamine As an Adjunctive Therapy for Major Depression (2)NCT04939649 · University of Dublin, Trinity College	Completed	Phase 3	ketamine	1
NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar DepressionNCT03396601 · NeuroRx, Inc.	Unknown status	Phase 3	ketamine	2
Ketamine Versus Electroconvulsive Therapy in DepressionNCT03674671 · University of Ottawa	Suspended	Phase 3	ketamine	4
Ketamine for Treatment-Resistant Bipolar DisorderNCT05004896 · Joshua Rosenblat	Completed	Phase 2	ketamine	3
Maintenance Ketamine Infusions for Treatment-Resistant Bipolar DepressionNCT05339074 · Joshua Rosenblat	Completed	Phase 2	ketamine	3
FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar DepressionNCT06620042 · Brian Barnett	Completed	Phase 2	ketamine	2
Trial of Ketamine and Lithium Therapy in Bipolar DepressionNCT01768767 · Yale University	Withdrawn	Phase 2	ketamine	—
Sequential Therapy for the Treatment of Severe Bipolar Depression.NCT02974010 · NeuroRx, Inc.	Completed	Phase 2	ketamine	4
Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar DepressionNCT03965871 · Celon Pharma SA	Completed	Phase 2	ketamine	12
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar DepressionNCT06506019 · University Health Network, Toronto	Active, not recruiting	Phase 1	psilocybin	1
Ketamine as an Adjunctive Therapy for Major DepressionNCT03256162 · St Patrick's Hospital, Ireland	Completed	Phase 1	ketamine	1
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:NCT03573349 · Mayo Clinic	Active, not recruiting	Early Phase 1	ketamine	1
Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.NCT02593643 · Sunnybrook Health Sciences Centre	Completed	Early Phase 1	ketamine	1
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy RecommendationNCT07097025 · Dr.Yoav Domany	Completed	N/A	ketamine	2
A Naturalistic Study of Ketamine for Treatment Resistant Mood DisordersNCT04226963 · Medical University of Gdansk	Completed	N/A	ketamine	1
Naturalistic Study of Ketamine in the Treatment of DepressionNCT05249309 · Hospital de Clinicas de Porto Alegre	Unknown status	N/A	ketamine	2
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in DepressionNCT04701866 · Douglas Mental Health University Institute	Completed	Not applicable	ketamine	2
The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)NCT04399070 · Yan Qiu	Unknown status	Not applicable	ketamine	1
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in DepressionNCT01309581 · James Murrough	Terminated	Not applicable	ketamine	1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.