Seven molecules
Substances
Each of these is being tested as a medicine somewhere on the federal registry. Ketamine appears only where the indication is psychiatric: it is also one of the world’s most common surgical anaesthetics, and those trials are a different subject.
LSD
Lysergic acid diethylamide
52 trials · 5 in Phase 3
8 recruiting
Psilocybin
Psilocybin
302 trials · 14 in Phase 3
100 recruiting
MDMA
3,4-Methylenedioxymethamphetamine
117 trials · 8 in Phase 3
24 recruiting
Ketamine
Ketamine and esketamine
522 trials · 70 in Phase 3
83 recruiting
DMT
Dimethyltryptamine and ayahuasca
72 trials · 0 in Phase 3
11 recruiting
Ibogaine
Ibogaine and noribogaine
8 trials · 0 in Phase 3
1 recruiting
Mescaline
Mescaline
3 trials · 0 in Phase 3
Counts from ClinicalTrials.gov API v2, data build 2026-10-06.