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CompletedPhase 2Results posted

CAP-Ketamine for Antidepressant Resistant PTSD

NCT02655692 · VA Office of Research and Development

Closed to entry
Status
Not accepting participants
Phase 2
Phase
163
Target enrolment
3
Study sites
3 US states

What it is testing

Summary

The purpose of this study is to test the safety and efficacy of repeated doses of ketamine as compared to placebo, in reducing symptoms of Posttraumatic Stress Disorder (PTSD) in an active duty military and Veteran population.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • PTSD Checklist (PCL)

    Measured over Session 1 -Day 0

  • The PTSD Checklist (PCL)

    Measured over Session 2 - Day 1

  • The PTSD Checklist (PCL)

    Measured over Session 3 - Day 3

  • The PTSD Checklist (PCL)

    Measured over Session 4 - Day 7

  • The PTSD Checklist (PCL)

    Measured over Session 5 - Day 10

  • The PTSD Checklist (PCL)

    Measured over Session 6 - Day 14

  • The PTSD Checklist (PCL)

    Measured over Session 7 - Day 17

  • The PTSD Checklist (PCL)

    Measured over Session 8 - Day 21

  • The PTSD Checklist (PCL)

    Measured over Session 9 - Day 24

  • The PTSD Checklist (PCL)

    Measured over Follow-up 1 - Day 25

  • The PTSD Checklist (PCL)

    Measured over Follow-up 2 - Day 28

  • The PTSD Checklist (PCL)

    Measured over Follow-up 3 - Day 29

  • The PTSD Checklist (PCL)

    Measured over Follow-up 4 - Day 35

  • The PTSD Checklist (PCL)

    Measured over Follow-up 5 - Day 42

  • The PTSD Checklist (PCL)

    Measured over Follow-up 6 - Day 49

  • The PTSD Checklist (PCL)

    Measured over Follow-up 7 - Day 56

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 70 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * male or female Veterans or active duty military personnel between the ages of 18 and 70 years * diagnosis of PTSD * history of trialing one or more antidepressant medications with little to no PTSD symptom improvement * ability to provide written informed consent Exclusion Criteria: * females who are currently pregnant or breastfeeding * current high risk for suicide * history of severe head injury

Where

3 study sites

FacilityCityRegionCountry
VA Connecticut Healthcare System West Haven Campus, West Haven, CTWest HavenConnecticutUnited States
Minneapolis VA Health Care System, Minneapolis, MNMinneapolisMinnesotaUnited States
Brooke Army Medical CenterSan AntonioTexasUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT02655692 on ClinicalTrials.gov →

Last updated in the registry 2022-06-02. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

All 9 trials from VA Office of Research and Development →