CompletedNot applicable

The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia

NCT05474183 · Fayoum University Hospital

Closed to entry

Status

Not accepting participants

Not applicable

Phase

Target enrolment

Study sites

Outside the US

What it is testing

Summary

Optimal multimodal opioid-sparing analgesic technique is considered as one of the most important Enhanced recovery pathways (ERPs) or enhanced recovery after surgery (ERAS) interventions that mitigate the undesirable effects of surgical stress response. Implementation of ERP has been shown to reduce postoperative complications and shorten the hospital LOS.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

The total postoperative fentanyl consumption (μg)
Measured over the first 48 hours postoperative

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 65 Years

Ages

All

Sex

Accepted

Healthy volunteers

Inclusion Criteria: * Age 18 - 65 years * Ejection fraction (EF) \> 35% * Elective isolated CABG * Valve surgery, Atrial septal defect (ASD) closure * Cross clamp time ≤ 90 min * Cardiopulmonary bypass time ≤ 120 min. Exclusion Criteria: * Poor left ventricular function with intra-aortic balloon pump support * Recent myocardial infarction (last seven days) * Combined procedure (i.e., CABG + other heart/vascular procedure) * Emergency surgery, and Redo surgery,Hepatic or renal failure, creatinine \>1.5 -History of neurological disorders or convulsions

Where

1 study site

Facility	City	Region	Country
Fayoum University hospital	Al Fayyum	Faiyum Governorate	Egypt

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT05474183 on ClinicalTrials.gov →

Last updated in the registry 2023-05-24. Registry records change; this page reflects the data build of 2026-08-25.

Where this trial sits

Substance

Ketamine