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CompletedPhase 1

A Study To Examine The Effects Of PF-04958242 On Ketamine-Induced Cognitive Impairment In Healthy Volunteers

NCT01749098 · Biogen

Closed to entry
Status
Not accepting participants
Phase 1
Phase
29
Target enrolment
2
Study sites
1 US states

What it is testing

Summary

To assess if PF-04958242 can attenuate the ketamine-induced cognitive impairment in verbal learning and memory, episodic memory and spatial working memory in healthy volunteers.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Test score on the Hopkins Verbal Learning Test - Immediate Recall

    Measured over Day 5

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

21 Years to 45 Years
Ages
MALE
Sex
Accepted
Healthy volunteers
Inclusion Criteria: * Healthy male subjects 21 - 45 years old. * Able to read and write English as primary language. * Subjects who are willing to comply with study procedures. Exclusion Criteria: * History of any substance abuse or dependence disorder meeting DSM-IV criteria and/or by SCID-NP within the past 12 months, with the exception of nicotine. * Known sensitivity to ketamine * Any history of DSM-IV Axis I psychiatric disorders, determined by SCID-NP interview or diagnoses in the view of the investigator.

Where

2 study sites

FacilityCityRegionCountry
Pfizer Investigational SiteNew HavenConnecticutUnited States
Pfizer Investigational SiteWest HavenConnecticutUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT01749098 on ClinicalTrials.gov →

Last updated in the registry 2019-11-21. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

Indication

Recruiting in

All 2 trials from Biogen →