| Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma PatientsNCT06903819 · Texas Tech University Health Sciences Center | Recruiting | Phase 4 | ketamine | 2 |
| Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECTNCT05655754 · Medical University of Vienna | Recruiting | Phase 4 | ketamine | 1 |
| A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited | Recruiting | Phase 3 | psilocybin | 68 |
| PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence StudyNCT06713616 · Yale University | Recruiting | Phase 3 | ketamine | 8 |
| Neurobiology of SuicideNCT02543983 · National Institute of Mental Health (NIMH) | Recruiting | Phase 2 | ketamine | 1 |
| Psilocybin-Assisted Therapy for Intergenerational TraumaNCT06899165 · Rachel Yehuda | Recruiting | Phase 2 | psilocybin | 1 |
| TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer SurvivorsNCT06801041 · M.D. Anderson Cancer Center | Recruiting | Phase 2 | psilocybin | 1 |
| Investigation to Understand and Optimize PsilocybinNCT06512194 · Charles Raison | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin Therapy for Depression in Parkinson's DiseaseNCT06455293 · Joshua Woolley, MD, PhD | Recruiting | Phase 2 | psilocybin | 1 |
| A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and AnxietyNCT06820723 · Ohio State University | Recruiting | Phase 2 | psilocybin | 1 |
| The Efficacy of Psilocybin Therapy for Depression in Parkinson's DiseaseNCT07610369 · Yale University | Recruiting | Phase 2 | psilocybin | 1 |
| Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionNCT06511908 · National Institute of Mental Health (NIMH) | Recruiting | Phase 2 | ketamine | 1 |
| Ketamine for Combined Depression and Alcohol Use DisorderNCT06090422 · University Hospital of North Norway | Recruiting | Phase 1 / Phase 2 | ketamine | 1 |
| Lysergic Acid Diethylamide (LSD) in Palliative CareNCT05883540 · University Hospital, Basel, Switzerland | Recruiting | Phase 2 | lsd | 4 |
| Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid DepressionNCT06419439 · VA Office of Research and Development | Recruiting | Phase 2 | ketamine | 1 |
| Psilocybin rTMS for Treatment Resistant DepressionNCT06132178 · University of Texas at Austin | Recruiting | Phase 2 | psilocybin | 1 |
| A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With DepressionNCT06597695 · Juliana Zambrano, MD, MPH | Recruiting | Phase 1 / Phase 2 | ketamine | 1 |
| Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderNCT03065335 · National Institute of Mental Health (NIMH) | Recruiting | Phase 1 | ketamine | 1 |
| Psilocybin in Chronic Low Back Pain and DepressionNCT06355414 · Johns Hopkins University | Recruiting | Phase 1 | psilocybin | 1 |
| Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionNCT03973268 · National Institute of Mental Health (NIMH) | Recruiting | Phase 1 | ketamine | 1 |
| Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in HumansNCT06671977 · Deepak C. D'Souza | Recruiting | Phase 1 | dmt | 1 |
| Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency DepartmentNCT06085937 · Lindsay Maguire, MD | Recruiting | Phase 1 | ketamine | 2 |
| Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's DiseaseNCT04123314 · Johns Hopkins University | Recruiting | Early Phase 1 | psilocybin | 1 |
| Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic StudyNCT07247968 · Min Su | Recruiting | Early Phase 1 | ketamine | 2 |
| Cognitive Training as an Adjunct to Ketamine in Real-world ClinicsNCT06526078 · University of Pittsburgh | Recruiting | Not applicable | ketamine | 3 |
| Retrospective Analyses of the Greenbrook Database Evaluating Mental Health TreatmentsNCT06997549 · Neuronetics | Recruiting | N/A | ketamine | 1 |
| Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-LifeNCT06824532 · Albany Research Institute, Inc. | Recruiting | N/A | ketamine | 1 |
| Anhedonia, Development, and Emotions: Phenotyping and TherapeuticsNCT05487885 · Erika Forbes | Completed | Phase 4 | ketamine | 1 |
| Propofol-Enhanced Assessment of Ketamine for Chronic Pain and DepressionNCT06317636 · Stanford University | Active, not recruiting | Phase 4 | ketamine | 1 |
| Effect of Esketamine on Postoperative Depression、Gut Microbiota、Bispectral Index Data of Depression Patients Undergoing Breast Cancer Operation (ESPOD-BI)NCT04303325 · China Medical University, China | Unknown status | Phase 4 | ketamine | 1 |
| A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health | Completed | Phase 4 | ketamine | 11 |
| Effectiveness of Ketamine Treatment for Three Consecutive Days in DepressionNCT05026203 · Mahidol University | Completed | Phase 4 | ketamine | 1 |
| The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel DiseaseNCT05506787 · Jinling Hospital, China | Completed | Phase 4 | ketamine | 1 |
| Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency DepartmentNCT04266288 · MercyOne Des Moines Medical Center | Completed | Phase 4 | ketamine | 1 |
| A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)NCT03149991 · Massachusetts General Hospital | Completed | Phase 4 | ketamine | 6 |
| Ketamine for Depression: An MRI StudyNCT02544607 · Massachusetts General Hospital | Completed | Phase 4 | ketamine | 1 |
| Ketamine Co-induction for Patients With Major Depressive DisorderNCT03666494 · University of Saskatchewan | Unknown status | Phase 4 | ketamine | — |
| Intranasal Ketamine for Late-Life Depression and Suicidal IdeationNCT02295787 · Massachusetts General Hospital | Withdrawn | Phase 4 | ketamine | — |
| Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major DepressionNCT02924090 · University of Manitoba | Unknown status | Phase 4 | ketamine | 1 |
| The Use of Ketamine as an Anaesthetic During Electroconvulsive TherapyNCT01306760 · University of Aberdeen | Completed | Phase 4 | ketamine | 1 |
| Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive DiseaseNCT02783430 · University Hospital, Lille | Completed | Phase 2 / Phase 3 | ketamine | 9 |
| Frontline Clinician Psilocybin StudyNCT05163496 · University of Washington | Completed | Phase 3 | psilocybin | 1 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)NCT03113968 · Bo Hu | Completed | Phase 2 / Phase 3 | ketamine | 5 |
| An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment AlternativesNCT04476446 · Janssen-Cilag, S.A. | Completed | Phase 3 | ketamine | 8 |
| Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol AbuseNCT03539887 · The University of Texas Health Science Center, Houston | Completed | Phase 3 | ketamine | 1 |
| Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency DepartmentNCT03436121 · Maria Pacella | Withdrawn | Phase 2 / Phase 3 | ketamine | — |
| A Study to Decrease Suicidal Thinking Using KetamineNCT02418702 · United States Naval Medical Center, San Diego | Withdrawn | Phase 3 | ketamine | 1 |
| Emergency Ketamine Treatment of Suicidal IdeationNCT02183272 · University of Cincinnati | Unknown status | Phase 2 / Phase 3 | ketamine | 1 |
| A Study of Ketamine Infusions to Treat Clinically-depressed ICU PatientsNCT05803551 · Mayo Clinic | Terminated | Phase 2 | ketamine | 1 |
| Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic MalignanciesNCT07336238 · University of Washington | Active, not recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of PsilocybinNCT06341426 · University Health Network, Toronto | Active, not recruiting | Phase 2 | psilocybin | 2 |
| Psilocybin-Assisted Therapy as a Treatment for DepressionNCT07582120 · Washington University School of Medicine | Not yet recruiting | Phase 2 | psilocybin | 1 |
| Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of DepressionNCT07565909 · University of Washington | Not yet recruiting | Phase 2 | psilocybin | — |
| Ketamine for the Treatment of Depression in Parkinson's DiseaseNCT04944017 · Yale University | Completed | Phase 2 | ketamine | 1 |
| A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant DepressionNCT02918318 · Janssen Pharmaceutical K.K. | Completed | Phase 2 | ketamine | 43 |
| Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive ImpairmentNCT06069843 · Icahn School of Medicine at Mount Sinai | Active, not recruiting | Phase 2 | ketamine | 1 |
| Psilocybin Therapy for Depression and Anxiety in Parkinson's DiseaseNCT04932434 · Joshua Woolley, MD, PhD | Completed | Phase 2 | psilocybin | 1 |
| Ketamine for the Treatment of Opioid Use Disorder and DepressionNCT04177706 · Medical University of South Carolina | Completed | Phase 2 | ketamine | 1 |
| Psilocybin-assisted Therapy for Alcohol Use DisorderNCT06444243 · University of Sydney | Unknown status | Phase 2 | psilocybin | — |
| The Effect of Psilocybin on MDD Symptom Severity and Synaptic DensityNCT04630964 · Section for Affective Disorders; Northern Stockholm Psychiatry | Completed | Phase 2 | psilocybin | 1 |
| Intravenous Ketamine Plus Neurocognitive Training for DepressionNCT03237286 · Rebecca Price | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSDNCT06141876 · Apex Labs Ltd. | Unknown status | Phase 2 | psilocybin | — |
| Clinical Study of GH001 in DepressionNCT04698603 · GH Research Ireland Limited | Completed | Phase 1 / Phase 2 | dmt | 1 |
| Effect of SSRIs on Response to Psilocybin TherapyNCT05594667 · Cybin Therapeutics Inc. | Withdrawn | Phase 2 | psilocybin | 1 |
| Ketamine and Epigenetic AgingNCT05294835 · TruDiagnostic | Unknown status | Phase 2 | ketamine | 1 |
| Study of Ketamine for Depression in Cancer Patients Receiving Palliative CareNCT03410446 · University Health Network, Toronto | Completed | Phase 2 | ketamine | 1 |
| Examining the Impact of Sirolimus on Ketamine's Antidepressant EffectsNCT02487485 · Yale University | Completed | Phase 2 | ketamine | 2 |
| Ketamine and Nitroprusside for DepressionNCT03102736 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 | ketamine | 1 |
| Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin TransporterNCT02717052 · Medical University of Vienna | Unknown status | Phase 2 | ketamine | 1 |
| Rapid Antidepressant Effects of Ketamine in Major DepressionNCT00088699 · National Institute of Mental Health (NIMH) | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department PatientsNCT02106325 · NYU Langone Health | Completed | Phase 2 | ketamine | 2 |
| Ketamine Plus Lithium in Treatment-Resistant DepressionNCT01880593 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 | ketamine | 1 |
| Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)NCT00749203 · Dennis Charney | Completed | Phase 2 | ketamine | 1 |
| Ketamine for Depression and Suicide RiskNCT02094898 · Mayo Clinic | Completed | Phase 2 | ketamine | 1 |
| Oral Ketamine in the Treatment of Depression and Anxiety in Patients With CancerNCT01680172 · Mayo Clinic | Terminated | Phase 2 | ketamine | 2 |
| Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural ConnectomeNCT06698848 · Massachusetts General Hospital | Active, not recruiting | Phase 1 | ketamine | 1 |
| Fixed Order, Open-Label, Dose-Escalation Study of DMT in HumansNCT04711915 · Yale University | Active, not recruiting | Phase 1 | dmt | 1 |
| A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant DepressionNCT05268497 · Janssen Research & Development, LLC | Withdrawn | Phase 1 | ketamine | 5 |
| PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related BurnoutNCT05557643 · University of Utah | Completed | Phase 1 | psilocybin | 1 |
| [11C]-(R)-Rolipram to Measure cAMP Signaling Before and After KetamineNCT05522673 · National Institute of Mental Health (NIMH) | Terminated | Phase 1 | ketamine | 1 |
| A Study of HR071603(Ketamine Nasal Spray) in Healthy SubjectsNCT04108234 · Jiangsu HengRui Medicine Co., Ltd. | Completed | Phase 1 | ketamine | 1 |
| Ketamine Interleaved With Electroconvulsive Therapy for DepressionNCT04082858 · St Patrick's Hospital, Ireland | Terminated | Phase 1 | ketamine | 1 |
| Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS SurvivorsNCT02950467 · Joshua Woolley | Completed | Phase 1 | psilocybin | 1 |
| Ketamine for Low Mood States in the ERNCT01209845 · Yale University | Completed | Phase 1 | ketamine | 1 |
| Intravenous Ketamine Effects on Functional NeuroanatomyNCT04205890 · Neurological Associates of West Los Angeles | Withdrawn | Phase 1 | ketamine | 1 |
| Ketamine for Depression and Alcohol DependenceNCT01551329 · Yale University | Completed | Phase 1 | ketamine | 1 |
| Ketamine for Relapse Prevention in Recurrent Depressive DisorderNCT02661061 · St Patrick's Hospital, Ireland | Terminated | Phase 1 | ketamine | 1 |
| Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)NCT02911597 · Stanford University | Completed | Phase 1 | ketamine | 1 |
| Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous KetamineNCT02289248 · Yale University | Completed | Phase 1 | ketamine | 2 |
| Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female SubjectsNCT01046630 · AstraZeneca | Completed | Phase 1 | ketamine | 2 |
| Mood Effects of Serotonin Agonists: DepressionNCT07017478 · University of Chicago | Completed | Early Phase 1 | lsd | 1 |
| Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI CancersNCT06001372 · University of Utah | Terminated | Early Phase 1 | ketamine | 1 |
| Low-Dose Intravenous Ketamine for Adolescents With Depression and Suicidal Ideation in the Emergency DepartmentNCT05217706 · Rady Children's Hospital, San Diego | Unknown status | Early Phase 1 | ketamine | 1 |
| Examining The Effect Of Ketamine On Glutamate/Glutamine CyclingNCT02037035 · Yale University | Completed | Early Phase 1 | ketamine | 1 |
| The Effectiveness and Safety of Esketamine in Modified Electroconvulsive TherapyNCT04777110 · First Affiliated Hospital of Chongqing Medical University | Unknown status | Early Phase 1 | ketamine | — |
| Ketamine for Depression Relapse Prevention Following ECTNCT02414932 · St Patrick's Hospital, Ireland | Completed | Early Phase 1 | ketamine | 1 |
| Ketamine for Preventing Depression in Patients Undergoing Treatment for Pancreatic or Head and Neck CancersNCT02442739 · Cedars-Sinai Medical Center | Withdrawn | Early Phase 1 | ketamine | 1 |
| Study of Oral Ketamine Versus Placebo for Treating Depression in Patients Undergoing Treatment for CancerNCT02836288 · Scott A. Irwin, MD, PhD | Completed | Early Phase 1 | ketamine | 1 |
| Using Virtual Reality to Control the Audio-visual Inputs During Ketamine/Esketamine TreatmentNCT06139016 · Yale University | Completed | Not applicable | ketamine | 1 |
| Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe DepressionNCT07374198 · Chinese PLA General Hospital | Not yet recruiting | Not applicable | ketamine | — |
| Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe DepressionNCT07374211 · Chinese PLA General Hospital | Not yet recruiting | Not applicable | ketamine | — |
| Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer SurgeryNCT07367542 · Chinese PLA General Hospital | Not yet recruiting | Not applicable | ketamine | 1 |
| Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine TreatmentNCT05719909 · University of Pittsburgh | Suspended | Not applicable | ketamine | 1 |
| Long Term Follow Up KET-PDNCT06164756 · Yale University | Enrolling by invitation | N/A | ketamine | 1 |
| (GluEsk) Glutamate and EsketamineNCT06432322 · University of Oxford | Completed | Not applicable | ketamine | 1 |
| Low-Income Group Psilocybin Assisted Therapy for DepressionNCT06372197 · Matthew Hicks | Completed | Not applicable | psilocybin | 1 |
| Glutamate Emotion Memory StudyNCT05809609 · University of Oxford | Unknown status | Not applicable | ketamine | 1 |
| Intranasal Ketamine in Ultra-REsistant Depression (SURE-ECT Non Responders)NCT05137938 · Centre for Addiction and Mental Health | Completed | Not applicable | ketamine | 1 |
| Reward Emotion Learning and Ketamine StudyNCT04850911 · University of Oxford | Unknown status | Not applicable | ketamine | 1 |
| Effect of Low-dose Esketamine on Postoperative Depression in Patients With Breast CancerNCT04850937 · Yangzhou University | Completed | Not applicable | ketamine | 1 |
| Cognitive Recovery After Electroconvulsive Therapy and General AnesthesiaNCT02761330 · Washington University School of Medicine | Completed | Not applicable | ketamine | 1 |
| The Efficacy and Safety of S-ketamine in Elective Cesarean SectionNCT04657107 · Beijing Obstetrics and Gynecology Hospital | Unknown status | Not applicable | ketamine | — |
| Dance Movement Therapy in the Treatment of Depressed Patients: A Randomised Controlled TrialNCT04421651 · University of Jyvaskyla | Completed | Not applicable | dmt | — |
| Low Dose Ketamine Infusion for the Treatment of Resistant DepressionNCT04283058 · Loma Linda University | Withdrawn | N/A | ketamine | 1 |
| Physiological and Cognitive Biomarkers for Ketamine's Antidepressant EffectsNCT02669043 · Massachusetts General Hospital | Terminated | Not applicable | ketamine | 1 |
| Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive SymptomsNCT02422303 · The University of Texas Health Science Center at San Antonio | Terminated | Not applicable | ketamine | 1 |
| Treatment of Suicidal Ideation With Intravenous Ketamine InfusionNCT01887990 · University of Alabama at Birmingham | Completed | Not applicable | ketamine | 1 |
| Ketamine Use in Electroconvulsive TherapyNCT02012335 · Hospital de Clinicas de Porto Alegre | Withdrawn | Not applicable | ketamine | 1 |
| Ketamine Anesthesia in Electroconvulsive TherapyNCT01367119 · Mayo Clinic | Completed | Not applicable | ketamine | 1 |
| Neuromodulation to Facilitate the Effect of KetamineNCT01816958 · The Neuroscience Center, LLC | Completed | N/A | ketamine | 1 |