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Indication

Major Depressive Episode

12 registered trials testing Ketamine for this indication, 4 recruiting now.

Sponsors register this under 2 different names, all collected here: Major Depressive Episode · Major Depressive Episode (MDE)

12
Registered trials
4
Recruiting
3
In Phase 3

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Trials

All 12 trials for Major Depressive Episode

TrialStatusPhaseSubstanceSites
Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression PatientsNCT06508710 · Assistance Publique - Hôpitaux de ParisRecruitingPhase 3ketamine4
University of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · Mark NiciuRecruitingN/Aketamine1
At-Home tDCS as Maintenance TherapyNCT07269964 · Technical University of MunichRecruitingNot applicableketamine2
Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot StudyNCT06732089 · Unity Health TorontoRecruitingN/Aketamine1
Ketamine as an Anaesthetic Agent in Electroconvulsive Therapy (ECT)NCT00680433 · Northside Clinic, AustraliaCompletedPhase 4ketamine1
Ketamine As an Adjunctive Therapy for Major Depression (2)NCT04939649 · University of Dublin, Trinity CollegeCompletedPhase 3ketamine1
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)NCT03113968 · Bo HuCompletedPhase 2 / Phase 3ketamine5
Ketamine for Suicidality in Bipolar DepressionNCT01944293 · New York State Psychiatric InstituteCompletedPhase 1 / Phase 2ketamine1
Investigation of Antidepressant Efficacy of Oral Ketamine TreatmentNCT02992496 · Medical University of ViennaUnknown statusPhase 2ketamine1
A Study of Ketamine as an AntidepressantNCT01441505 · The University of New South WalesUnknown statusPhase 2ketamine1
Ketamine as an Adjunctive Therapy for Major DepressionNCT03256162 · St Patrick's Hospital, IrelandCompletedPhase 1ketamine1
Biomarker Discovery for Suicide Precision Circuit TherapeuticsNCT07723066 · Massachusetts General HospitalNot yet recruitingN/Aketamine—

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.