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Low-dose S-Ketamine and Postpartum Depression in Parturients With Prenatal Depression

NCT03927378 · Peking University First Hospital

Closed to entry
Status
Not accepting participants
Not applicable
Phase
364
Target enrolment
7
Study sites
Outside the US

What it is testing

Summary

Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ketamine in anti-depression. We speculate that, for pregnant women with prenatal depression, low-dose s-ketamine infusion after childbirth may reduce the incidence of postpartum depression.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • The incidence of depression at 42 days after childbirth.

    Measured over At 42 days after childbirth.

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years
Ages
FEMALE
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Parturients with age ≥18 years; * Presence of prenatal depression (EPDS score ≥10); Exclusion Criteria: 1. A clear history of mental illness (depression, schizophrenia, etc.) or communication difficulties; 2. Severe pregnancy complications, such as severe preeclampsia, placental implantation, HELLP (syndrome hemolytic anemia, elevated liver function and low platelet count) syndrom, placenta previa, and placental abruption; 3. American Society of Anesthesiologists classification ≥III; 4. Presence of contraindications to ketamine/s-ketamine use, such as refractory hypertension, severe cardiovascular disease (New York Heart Association classification ≥III), and hyperthyroidism.

Where

7 study sites

FacilityCityRegionCountry
Peking University First HospitalBeijingBeijing MunicipalityChina
Beijing Tiantan HospitalBeijingBeijing MunicipalityChina
Peking University International HospitalBeijingBeijing MunicipalityChina
Hunan Provincial Maternal and Child Health Care HospitalChangshaHunanChina
Huaian Maternal and Child Health Care HospitalHuaianJiangsuChina
Nanjing Maternal and Child Health Care HospitalNanjingJiangsuChina
Women's Hospital School Of Medicine Zhejiang UniversityHanzhouZhejiangChina

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

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NCT03927378 on ClinicalTrials.gov →

Last updated in the registry 2023-04-04. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

All 7 trials from Peking University First Hospital →