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CompletedPhase 4Results posted

Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery

NCT03861988 · Stanford University

Closed to entry
Status
Not accepting participants
Phase 4
Phase
45
Target enrolment
1
Study sites
1 US states

What it is testing

Summary

This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery. Half of participants will receive a ketamine infusion during surgery, while the other half will receive a placebo (normal saline) during surgery.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Montgomery-Asberg Depression Rating Scale (MADRS) Score

    Measured over Post-intervention days 1, 2 and 3

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 80 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Patient presenting for non-cardiac, non-intracranial surgery * Major Depressive Disorder Exclusion Criteria: * Pregnant of breastfeeding women

Where

1 study site

FacilityCityRegionCountry
Stanford UniversityStanfordCaliforniaUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT03861988 on ClinicalTrials.gov →

Last updated in the registry 2023-10-05. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits