| Postpartum Perineal Pain After Obstetric Anal Sphincter InjuriesNCT03470675 · Northwestern University | Completed | Phase 4 | ketamine | 1 |
| Anhedonia, Development, and Emotions: Phenotyping and TherapeuticsNCT05487885 · Erika Forbes | Completed | Phase 4 | ketamine | 1 |
| A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray TreatmentNCT04829318 · Janssen-Cilag Ltd. | Completed | Phase 4 | ketamine | 59 |
| Ketamine-assisted Therapy for Advanced GI CancerNCT06077487 · Brian Anderson, MD | Terminated | Phase 4 | ketamine | 1 |
| A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant DepressionNCT04599855 · Janssen Research & Development, LLC | Completed | Phase 4 | ketamine | 54 |
| The Impact of Perioperative Ketamine Infusion on Surgical RecoveryNCT04625283 · Vanderbilt University Medical Center | Completed | Phase 4 | ketamine | 1 |
| Ketamine + Cognitive Training for Suicidality in the Medical Setting: PilotNCT04154150 · Rebecca Price | Terminated | Phase 4 | ketamine | 1 |
| A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health | Completed | Phase 4 | ketamine | 11 |
| Ketamine Treatment Effects on Synaptic Plasticity in DepressionNCT04091971 · New York State Psychiatric Institute | Completed | Phase 4 | ketamine | 1 |
| Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac SurgeryNCT03861988 · Stanford University | Completed | Phase 4 | ketamine | 1 |
| Ketamine for Acute Pain Management After TraumaNCT04129086 · The University of Texas Health Science Center, Houston | Completed | Phase 4 | ketamine | 1 |
| Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in DepressionNCT01881763 · Northwell Health | Completed | Phase 4 | ketamine | 1 |
| Ketamine for Older Adults PilotNCT04504175 · Washington University School of Medicine | Completed | Phase 4 | ketamine | 5 |
| Ketamine Versus Fentanyl for Surgical AbortionsNCT04871425 · University of Washington | Completed | Phase 4 | ketamine | 1 |
| The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.NCT03156504 · Mayo Clinic | Completed | Phase 4 | ketamine | 4 |
| A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)NCT03149991 · Massachusetts General Hospital | Completed | Phase 4 | ketamine | 6 |
| Ketamine Infusion for Adolescent Depression and AnxietyNCT02579928 · Yale University | Completed | Phase 4 | ketamine | 2 |
| The Effect of Ketamine on the Length of Hospital Stay of Patients Hospitalized With Suicidal Ideation.NCT02997722 · Allen Richert | Terminated | Phase 4 | ketamine | 1 |
| Ketamine in the Treatment of Suicidal DepressionNCT01700829 · New York State Psychiatric Institute | Completed | Phase 4 | ketamine | 1 |
| Research Study for Major Depressive Disorder: Investigation of Glutamate MedicationsNCT00419003 · Baylor College of Medicine | Completed | Phase 4 | ketamine | 1 |
| Ketamine for Depression: An MRI StudyNCT02544607 · Massachusetts General Hospital | Completed | Phase 4 | ketamine | 1 |
| RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn PainNCT03305055 · Johns Hopkins University | Terminated | Phase 4 | ketamine | 1 |
| N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major DepressionNCT01260649 · Massachusetts General Hospital | Terminated | Phase 4 | ketamine | 1 |
| Treatment Study of Bipolar DepressionNCT00947791 · Icahn School of Medicine at Mount Sinai | Terminated | Phase 4 | ketamine | 1 |
| Ketamine For Suicidal IdeationNCT01507181 · James Murrough | Completed | Phase 4 | ketamine | 1 |
| NMDA Antagonists in Bipolar DepressionNCT01833897 · New York State Psychiatric Institute | Completed | Phase 4 | ketamine | 1 |
| Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility TrialNCT05233566 · Washington University School of Medicine | Completed | Phase 3 | ketamine | 1 |
| Opiate Suicide Study in Patients With Major DepressionNCT04116528 · Stanford University | Completed | Phase 3 | ketamine | 1 |
| A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)NCT03537014 · Resilient Pharmaceuticals | Completed | Phase 3 | mdma | 15 |
| A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)NCT04077437 · Resilient Pharmaceuticals | Completed | Phase 3 | mdma | 14 |
| A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSDNCT04714359 · Resilient Pharmaceuticals | Completed | Phase 3 | mdma | 15 |
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency DepartmentNCT04260607 · Naval Medical Center Camp Lejeune | Terminated | Phase 3 | ketamine | 1 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02417064 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 90 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02418585 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 48 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant DepressionNCT02422186 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 69 |
| A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant DepressionNCT02493868 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 155 |
| A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant DepressionNCT02497287 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 109 |
| A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant DepressionNCT02782104 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 173 |
| 54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03039192 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 56 |
| 54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03097133 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 61 |
| A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT03434041 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 30 |
| A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive DisorderNCT04338321 · Janssen-Cilag International NV | Completed | Phase 3 | ketamine | 171 |
| Frontline Clinician Psilocybin StudyNCT05163496 · University of Washington | Completed | Phase 3 | psilocybin | 1 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)NCT03113968 · Bo Hu | Completed | Phase 2 / Phase 3 | ketamine | 5 |
| Ketamine for Severe Adolescent Depression: Intermediate-term Safety and EfficacyNCT03889756 · Yale University | Terminated | Phase 2 / Phase 3 | ketamine | 1 |
| Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol AbuseNCT03539887 · The University of Texas Health Science Center, Houston | Completed | Phase 3 | ketamine | 1 |
| Ketamine to Prevent PPD After CesareanNCT04227704 · Washington University School of Medicine | Completed | Phase 3 | ketamine | 1 |
| Ketamine for Treatment Resistant Late-Life DepressionNCT02556606 · VA Office of Research and Development | Completed | Phase 3 | ketamine | 1 |
| Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)NCT02397889 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 / Phase 3 | ketamine | 1 |
| Ketamine Infusion for Comorbid PTSD and Chronic PainNCT04322968 · VA Ann Arbor Healthcare System | Completed | Phase 3 | ketamine | 1 |
| Study on the Use of Low Dose Ketamine After Gastric Bypass and GastrectomyNCT02452060 · NYU Langone Health | Completed | Phase 2 / Phase 3 | ketamine | 1 |
| Ketamine-enhanced Prolonged Exposure Therapy in PTSDNCT04560660 · VA Office of Research and Development | Completed | Phase 2 | ketamine | 1 |
| A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive DisorderNCT06340958 · Clexio Biosciences Ltd. | Completed | Phase 2 | ketamine | 23 |
| Psilocybin-facilitated Treatment for Cocaine UseNCT02037126 · University of Alabama at Birmingham | Completed | Phase 2 | psilocybin | 1 |
| A Study of Psilocybin for Major Depressive Disorder (MDD)NCT03866174 · Usona Institute | Completed | Phase 2 | psilocybin | 11 |
| Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)NCT04772222 · University of Utah | Completed | Phase 2 | dmt | 5 |
| Safety and Efficacy of Low Dose MM120 for ADHD Proof of Concept TrialNCT05200936 · Definium Therapeutics US, Inc. | Completed | Phase 2 | lsd | 2 |
| A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety SymptomsNCT05407064 · Definium Therapeutics US, Inc. | Completed | Phase 2 | lsd | 22 |
| Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice CareNCT04950608 · Yvan Beaussant, MD, MSci | Completed | Phase 2 | psilocybin | 1 |
| Psilocybin-Assisted Therapy for the Treatment of Cancer-Related Anxiety in Patients With Metastatic CancerNCT05847686 · University of Washington | Completed | Phase 1 / Phase 2 | psilocybin | 1 |
| A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO StudyNCT04103892 · Clexio Biosciences Ltd. | Completed | Phase 2 | ketamine | 46 |
| Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous KetamineNCT04613453 · Yale University | Terminated | Phase 2 | ketamine | 1 |
| Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSDNCT04784143 · Resilient Pharmaceuticals | Terminated | Phase 2 | mdma | 1 |
| The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderNCT05312151 · COMPASS Pathways | Completed | Phase 2 | psilocybin | 3 |
| Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada)NCT03485287 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 2 |
| MDMA-Assisted Psychotherapy in People With Posttraumatic Stress DisorderNCT00090064 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| Randomized, Double-blind, Placebo-Controlled Pilot Study of MDMA-assisted Therapy for PTSDNCT01689740 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - IsraelNCT00402298 · Resilient Pharmaceuticals | Terminated | Phase 2 | mdma | 1 |
| Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress DisorderNCT01211405 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSDNCT01793610 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSDNCT01958593 · Resilient Pharmaceuticals | Terminated | Phase 2 | mdma | 1 |
| Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic AdultsNCT02008396 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening IllnessNCT02427568 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSDNCT03282123 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 12 |
| MDMA-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic PTSDNCT02876172 · Resilient Pharmaceuticals | Completed | Phase 1 / Phase 2 | mdma | 1 |
| A Study of Ketamine in Patients With Treatment-resistant DepressionNCT01627782 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 13 |
| A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant DepressionNCT01998958 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 25 |
| A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for SuicideNCT02133001 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 14 |
| A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant DepressionNCT02918318 · Janssen Pharmaceutical K.K. | Completed | Phase 2 | ketamine | 43 |
| Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for SuicideNCT03185819 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 51 |
| Open-label Study to Assess the Safety and Efficacy of Psilocybin With Psychotherapy in Adult Participants With FibromyalgiaNCT05128162 · Kevin Boehnke | Completed | Phase 2 | psilocybin | 1 |
| Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderNCT02461927 · VA Office of Research and Development | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant DepressionNCT02914769 · Universidade Federal do Rio Grande do Norte | Completed | Phase 1 / Phase 2 | dmt | 1 |
| Open Label Study of MDMA-assisted Psychotherapy for Treatment of PTSD With Optional fMRI Sub-StudyNCT04030169 · MAPS Europe B.V. | Completed | Phase 2 | mdma | 6 |
| Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative MechanismsNCT03429075 · Imperial College London | Completed | Phase 2 | psilocybin | 1 |
| Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSDNCT04889664 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 | ketamine | 1 |
| Repeated Neurocognitive Measurements in Depressed PatientsNCT04916548 · Rebecca Price | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Ketamine + Mindfulness for DepressionNCT05168735 · Rebecca Price | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Ketamine for the Treatment of Opioid Use Disorder and DepressionNCT04177706 · Medical University of South Carolina | Completed | Phase 2 | ketamine | 1 |
| Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress DisorderNCT00353938 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRDNCT05414422 · Perception Neuroscience | Completed | Phase 2 | ketamine | 21 |
| KAP for Depression in Abstinent Opioid UsersNCT05193318 · Medical University of South Carolina | Terminated | Phase 2 | ketamine | 1 |
| Efficacy of Repeated Ketamine Infusions for Treatment-resistant DepressionNCT02360280 · VA Office of Research and Development | Completed | Phase 2 | ketamine | 1 |
| Intravenous Ketamine Plus Neurocognitive Training for DepressionNCT03237286 · Rebecca Price | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy TrialNCT01458327 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant DepressionNCT04739865 · COMPASS Pathways | Completed | Phase 2 | psilocybin | 2 |
| Effects and Therapeutic Potential of Psilocybin in Alcohol DependenceNCT01534494 · University of New Mexico | Completed | Phase 2 | psilocybin | 1 |
| Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related AnxietyNCT00920387 · Multidisciplinary Association for Psychedelic Studies | Completed | Phase 2 | lsd | 1 |
| The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant DepressionNCT03775200 · COMPASS Pathways | Completed | Phase 2 | psilocybin | 25 |
| Safety and Efficacy of Psilocybin for Body Dysmorphic DisorderNCT04656301 · New York State Psychiatric Institute | Completed | Phase 2 | psilocybin | 1 |
| Ketamine to Improve Recovery After Cesarean Delivery - Part 1NCT04037085 · Grace Lim, MD, MS | Completed | Phase 2 | ketamine | 2 |
| A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol DependenceNCT02061293 · NYU Langone Health | Completed | Phase 2 | psilocybin | 2 |
| Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure TherapyNCT02727998 · Yale University | Terminated | Phase 2 | ketamine | 1 |
| The Effects of Sedatives on Tobacco Use DisorderNCT03813121 · Wake Forest University Health Sciences | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment OutcomeNCT02418195 · University of Alabama at Birmingham | Completed | Phase 2 | ketamine | 1 |
| CAP-Ketamine for Antidepressant Resistant PTSDNCT02655692 · VA Office of Research and Development | Completed | Phase 2 | ketamine | 3 |
| Low Dose Intravenous Ketamine in Treatment Resistant Depression PatientsNCT02935595 · The University of Texas Health Science Center, Houston | Completed | Phase 2 | ketamine | 1 |
| Effects of Psilocybin in Major Depressive DisorderNCT03181529 · Johns Hopkins University | Completed | Phase 2 | psilocybin | 1 |
| Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum DepressionNCT04011592 · The University of Texas Health Science Center, Houston | Terminated | Phase 2 | ketamine | 1 |
| Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant DepressionNCT03756129 · Novartis Pharmaceuticals | Completed | Phase 2 | ketamine | 12 |
| Ketamine for Reduction of Alcoholic RelapseNCT02649231 · University College, London | Completed | Phase 2 | ketamine | 2 |
| Sequential Therapy for the Treatment of Severe Bipolar Depression.NCT02974010 · NeuroRx, Inc. | Completed | Phase 2 | ketamine | 4 |
| Ketamine and Prolonged Exposure in PTSDNCT03960658 · Minneapolis Veterans Affairs Medical Center | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| The UTHealth Ketamine ProjectNCT02882711 · The University of Texas Health Science Center, Houston | Terminated | Phase 2 | ketamine | 1 |
| Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)NCT02422290 · New York State Psychiatric Institute | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Examining the Impact of Sirolimus on Ketamine's Antidepressant EffectsNCT02487485 · Yale University | Completed | Phase 2 | ketamine | 2 |
| Ketamine and Nitroprusside for DepressionNCT03102736 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 | ketamine | 1 |
| Ketamine for Suicidality in Bipolar DepressionNCT01944293 · New York State Psychiatric Institute | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Ketamine in Adolescents With Treatment-Resistant DepressionNCT02078817 · University of Minnesota | Completed | Phase 2 | ketamine | 1 |
| Ketamine in the Treatment of DepressionNCT01558063 · Columbia University | Completed | Phase 2 | ketamine | 1 |
| Persisting Effects of PsilocybinNCT02971605 · Johns Hopkins University | Completed | Phase 1 / Phase 2 | psilocybin | 1 |
| Rapid Antidepressant Effects of Ketamine in Major DepressionNCT00088699 · National Institute of Mental Health (NIMH) | Completed | Phase 1 / Phase 2 | ketamine | 1 |
| Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department PatientsNCT02106325 · NYU Langone Health | Completed | Phase 2 | ketamine | 2 |
| Ketamine Plus Lithium in Treatment-Resistant DepressionNCT01880593 · Icahn School of Medicine at Mount Sinai | Completed | Phase 2 | ketamine | 1 |
| Psychopharmacology of Psilocybin in Cancer PatientsNCT00465595 · Johns Hopkins University | Completed | Phase 2 | psilocybin | 1 |
| Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)NCT01920555 · Massachusetts General Hospital | Completed | Phase 2 | ketamine | 6 |
| Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)NCT00749203 · Dennis Charney | Completed | Phase 2 | ketamine | 1 |
| Intravenous Ketamine in the Treatment of Obsessive-Compulsive DisorderNCT01371110 · Wayne Goodman MD | Terminated | Phase 1 / Phase 2 | ketamine | 1 |
| MDMA-assisted Therapy in People With Anxiety Related to Advanced Stage CancerNCT00252174 · Brigham and Women's Hospital | Terminated | Phase 2 | mdma | 1 |
| Ketamine for Depression and Suicide RiskNCT02094898 · Mayo Clinic | Completed | Phase 2 | ketamine | 1 |
| Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive DisorderNCT00956085 · New York State Psychiatric Institute | Completed | Phase 2 | ketamine | 1 |
| A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive DisorderNCT02234011 · Mclean Hospital | Terminated | Phase 2 | ketamine | 1 |
| Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With OCDNCT02206776 · New York State Psychiatric Institute | Terminated | Phase 2 | ketamine | 1 |
| Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD)NCT01100255 · New York State Psychiatric Institute | Completed | Phase 2 | ketamine | 1 |
| A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive DisorderNCT01957410 · Janssen Research & Development, LLC | Terminated | Phase 2 | ketamine | 1 |
| Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)NCT02062658 · New York State Psychiatric Institute | Completed | Phase 2 | ketamine | 1 |
| Oral Ketamine in the Treatment of Depression and Anxiety in Patients With CancerNCT01680172 · Mayo Clinic | Terminated | Phase 2 | ketamine | 2 |
| Ketamine Infusion for Obsessive-Compulsive DisorderNCT01349231 · Yale University | Completed | Phase 2 | ketamine | 1 |
| Optimization of IV Ketamine for Treatment Resistant DepressionNCT00768430 · Baylor College of Medicine | Completed | Phase 2 | ketamine | 2 |
| Psilocybin-assisted CBT for DepressionNCT05227612 · University of California, Los Angeles | Completed | Phase 1 | psilocybin | 1 |
| KET-RO Plus RO DBT for Treatment Resistant DepressionNCT06138691 · Washington University School of Medicine | Completed | Phase 1 | ketamine | 1 |
| Multiple Ascending Dose Noribogaine PK/PD in Healthy VolunteersNCT06480981 · DemeRx NB | Completed | Phase 1 | ibogaine | 1 |
| Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)NCT05907213 · Grace Lim, MD, MS | Completed | Phase 1 | ketamine | 1 |
| Visual Surround Suppression and Perceptual Expectation Under PsilocybinNCT04424225 · University of Minnesota | Terminated | Phase 1 | psilocybin | 1 |
| Phase 1 Evaluation of (2R,6R)-HydroxynorketamineNCT04711005 · National Institute of Mental Health (NIMH) | Completed | Phase 1 | ketamine | 1 |
| [11C]-(R)-Rolipram to Measure cAMP Signaling Before and After KetamineNCT05522673 · National Institute of Mental Health (NIMH) | Terminated | Phase 1 | ketamine | 1 |
| Effect of Stimulant Drugs on Social PerceptionNCT03790618 · University of Chicago | Completed | Phase 1 | mdma | 1 |
| Mood Effects of Serotonin Agonists ExtendedNCT03934710 · University of Chicago | Completed | Phase 1 | lsd | 1 |
| Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS SurvivorsNCT02950467 · Joshua Woolley | Completed | Phase 1 | psilocybin | 1 |
| Ketamine as an Adjunctive Therapy for Major DepressionNCT03256162 · St Patrick's Hospital, Ireland | Completed | Phase 1 | ketamine | 1 |
| Ketamine for Relapse Prevention in Recurrent Depressive DisorderNCT02661061 · St Patrick's Hospital, Ireland | Terminated | Phase 1 | ketamine | 1 |
| Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use DisorderNCT05796791 · Medical University of South Carolina | Completed | Early Phase 1 | ketamine | 1 |
| Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI CancersNCT06001372 · University of Utah | Terminated | Early Phase 1 | ketamine | 1 |
| Effects of Drugs on Responses to Brain and Emotional ProcessesNCT04053036 · University of Chicago | Completed | Early Phase 1 | mdma | 1 |
| EEG Characteristics in ECTNCT04022226 · University of New Mexico | Completed | Early Phase 1 | ketamine | 1 |
| Inpatient Single Dose Interventions for Alcohol Use DisorderNCT04562779 · Denver Health and Hospital Authority | Completed | Early Phase 1 | ketamine | 1 |
| Ketamine for Depression Relapse Prevention Following ECTNCT02414932 · St Patrick's Hospital, Ireland | Completed | Early Phase 1 | ketamine | 1 |
| Ketamine Infusion for Social Anxiety DisorderNCT02083926 · Yale University | Completed | Early Phase 1 | ketamine | 1 |
| Psilocybin Cancer Anxiety StudyNCT00957359 · NYU Langone Health | Completed | Early Phase 1 | psilocybin | 1 |
| Using Virtual Reality to Control the Audio-visual Inputs During Ketamine/Esketamine TreatmentNCT06139016 · Yale University | Completed | Not applicable | ketamine | 1 |
| The Effects of Ketamine on Respiratory Stimulation and Transpulmonary PressuresNCT01969227 · Massachusetts General Hospital | Completed | Not applicable | ketamine | 2 |
| Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee ArthroplastyNCT07059429 · State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | Completed | Not applicable | ketamine | 1 |
| Role Of Non-Specific Effects in The Treatment of Depression With EsketamineNCT05910775 · Yale University | Terminated | Not applicable | ketamine | 1 |
| Psilocybin-facilitated Smoking Cessation Treatment: A Pilot StudyNCT01943994 · Johns Hopkins University | Completed | Not applicable | psilocybin | 2 |
| Treatment Resistant Depression (Pilot)NCT01179009 · Washington University School of Medicine | Completed | Not applicable | ketamine | 1 |
| Ketamine/Placebo Family History Positive StudyNCT00588952 · Yale University | Completed | Not applicable | ketamine | 1 |
| Cognitive Recovery After Electroconvulsive Therapy and General AnesthesiaNCT02761330 · Washington University School of Medicine | Completed | Not applicable | ketamine | 1 |
| Pediatric Laser Acupuncture and Renal BiopsyNCT01879826 · University of California, San Francisco | Completed | Not applicable | ketamine | 2 |
| Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant DepressionNCT02522377 · The Cleveland Clinic | Completed | Not applicable | ketamine | 1 |
| Effects of MDMA on Emotional and Social MemoriesNCT03050541 · University of Chicago | Completed | Not applicable | mdma | — |
| Physiological and Cognitive Biomarkers for Ketamine's Antidepressant EffectsNCT02669043 · Massachusetts General Hospital | Terminated | Not applicable | ketamine | 1 |
| Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive SymptomsNCT02422303 · The University of Texas Health Science Center at San Antonio | Terminated | Not applicable | ketamine | 1 |
| Treatment of Suicidal Ideation With Intravenous Ketamine InfusionNCT01887990 · University of Alabama at Birmingham | Completed | Not applicable | ketamine | 1 |
| PET Imaging of mGLuR5 With Drug ChallengeNCT01691092 · Yale University | Completed | Not applicable | ketamine | 3 |
| Ketamine Infusion for Treatment-resistant Major Depressive DisorderNCT01582945 · Massachusetts General Hospital | Completed | Not applicable | ketamine | 1 |
| Ketamine Versus Placebo for Treatment Resistant Major Depressive DisorderNCT01667926 · Massachusetts General Hospital | Completed | Not applicable | ketamine | 1 |
| Intranasal Ketamine in Treatment-Resistant DepressionNCT01304147 · James Murrough | Completed | Not applicable | ketamine | 1 |
| Effects of MDMA on Social and Emotional ProcessingNCT01849419 · University of Chicago | Completed | Not applicable | mdma | 1 |
| Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in DepressionNCT01309581 · James Murrough | Terminated | Not applicable | ketamine | 1 |
| Ketamine Anesthesia in Electroconvulsive TherapyNCT01367119 · Mayo Clinic | Completed | Not applicable | ketamine | 1 |