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The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures

NCT01969227 · Massachusetts General Hospital

Closed to entry
Status
Not accepting participants
Not applicable
Phase
15
Target enrolment
2
Study sites
1 US states

What it is testing

Summary

Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid and propofol requirements. The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of ketamine on breathing and electroencephalography in mechanically ventilated patients.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Inspiratory Airflow

    Measured over During spontaneous breathing trials at baseline (prior to ketamine infusion), after 60 minutes of ketamine infusion at 5 mcg/kg/min, and after 60 minutes of ketamine infusion at 10 mcg/kg/min

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Age ≥ 18 years admitted to ICU requiring mechanical ventilation * Suitable for spontaneous breathing trial * Candidate to received low dose ketamine by the primary critical care team Exclusion Criteria: * Esophageal injury * Allergic to ketamine * Known neurodegenerative disorders * Major neurologic disorders (elevated ICP)

Where

2 study sites

FacilityCityRegionCountry
Massachusetts General HospitalBostonMassachusettsUnited States
Beth Israel Deaconess Medical CenterBostonMassachusettsUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT01969227 on ClinicalTrials.gov →

Last updated in the registry 2026-05-19. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

Recruiting in

All 17 trials from Massachusetts General Hospital →