Indication

Post Traumatic Stress Disorder

86 registered trials testing LSD, Psilocybin, MDMA, Ketamine, DMT, Ibogaine for this indication, 25 recruiting now.

Sponsors register this under 10 different names, all collected here: PTSD · PTSD - Post Traumatic Stress Disorder · PTSD, Post Traumatic Stress Disorder · Post Traumatic Stress Disorder · Post Traumatic Stress Disorder PTSD · Post-Traumatic Stress Disorder · Post-Traumatic Stress Disorder (PTSD) · Post-Traumatic Stress Disorder, PTSD · Post-traumatic Stress Disorder · Post-traumatic Stress Disorder (PTSD)

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In Phase 3

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Trials

All 86 trials for Post Traumatic Stress Disorder

Trial	Status	Phase	Substance	Sites
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma PatientsNCT06903819 · Texas Tech University Health Sciences Center	Recruiting	Phase 4	ketamine	2
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSDNCT06414356 · Margaux M. Salas, PhD	Recruiting	Phase 4	ketamine	1
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderNCT07570654 · COMPASS Pathways	Recruiting	Phase 2 / Phase 3	psilocybin	1
Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive DisorderNCT07703722 · Khyber Medical University Peshawar	Recruiting	Phase 3	psilocybin	3
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use DisorderNCT07118839 · VA Office of Research and Development	Recruiting	Phase 2 / Phase 3	mdma	2
MDMA-assisted Massed Prolonged Exposure for PTSDNCT06117306 · Healing Breakthrough	Recruiting	Phase 3	mdma	1
Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral InjuryNCT06394284 · Herzog Hospital	Recruiting	Phase 3	mdma	1
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress DisorderNCT05790239 · Stephen Robert Marder	Recruiting	Phase 2	mdma	2
MDMA-Assisted CBCT for PTSD vs CBCT RCTNCT06044675 · Remedy	Recruiting	Phase 2	mdma	1
Preliminary Effectiveness of Individual and Group MDMA-assisted Therapy for Israeli Veterans With PTSD and Moral Injury.NCT05732155 · HaEmek Medical Center, Israel	Recruiting	Phase 2	mdma	1
Psilocybin-Assisted Therapy for Sexual Assault-Related PTSDNCT06902974 · Sunstone Medical	Recruiting	Phase 2	psilocybin	1
MDMA Therapy in Veterans With PTSDNCT07569159 · Sunstone Medical	Recruiting	Phase 2	mdma	1
Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSDNCT06386003 · Unity Health Toronto	Recruiting	Phase 2	psilocybin	1
Mindfulness-based Psilocybin Therapy for PTSDNCT07104916 · Anthony P King	Recruiting	Phase 2	psilocybin	1
MDMA-Assisted Massed Exposure Therapy for PTSDNCT07288151 · Emory University	Recruiting	Phase 2	mdma	1
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsNCT05786066 · Yale University	Recruiting	Phase 2	ketamine	1
Group vs Individual MDMA-Assisted Therapy for PTSD After the October 7, 2023 EventsNCT07469098 · Sheba Medical Center	Recruiting	Phase 2	mdma	2
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing TraumaNCT06888128 · Baylor College of Medicine	Recruiting	Phase 2	psilocybin	1
MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress DisorderNCT05837845 · Patricia Suppes	Recruiting	Phase 2	mdma	1
MDMA for AUD/PTSD ComorbidityNCT05943665 · Carolina L Haass-Koffler	Recruiting	Phase 2	mdma	1
Group Psilocybin-Assisted Therapy for Post-Traumatic Stress DisorderNCT07506395 · University of New Mexico	Recruiting	Phase 1	psilocybin	1
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine ResponseNCT05915013 · Yale University	Recruiting	Phase 1	ketamine	1
Open-Label Psilocybin Study in Transdiagnostic PopulationNCT06442423 · Yale University	Recruiting	Phase 1	psilocybin	1
Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSDNCT07737054 · Tel-Aviv Sourasky Medical Center	Recruiting	Early Phase 1	psilocybin	1
RIVER At Home Ketamine ProtocolsNCT06070766 · RIVER Foundation	Recruiting	N/A	ketamine	2
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health	Completed	Phase 4	ketamine	11
Epigenetics and MDMA-Assisted Psychotherapy for PTSDNCT06189027 · University of Southern California	Completed	Phase 3	mdma	1
MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSDNCT05979844 · Dr. Leslie Morland	Completed	Phase 3	mdma	1
A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSDNCT04714359 · Resilient Pharmaceuticals	Completed	Phase 3	mdma	15
Frontline Clinician Psilocybin StudyNCT05163496 · University of Washington	Completed	Phase 3	psilocybin	1
Ketamine Infusion for Comorbid PTSD and Chronic PainNCT04322968 · VA Ann Arbor Healthcare System	Completed	Phase 3	ketamine	1
To Test the Potential Efficacy of Repeated Intranasal Administration of Ketamine as a Treatment for PTSDNCT02398136 · Adriana Feder	Withdrawn	Phase 2 / Phase 3	ketamine	—
PsiloStudy: Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)NCT06853912 · Nathan Brashares Sackett	Active, not recruiting	Phase 2	psilocybin	1
Ketamine-enhanced Prolonged Exposure Therapy in PTSDNCT04560660 · VA Office of Research and Development	Completed	Phase 2	ketamine	1
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic TherapiesNCT07745569 · University of New Mexico	Not yet recruiting	Phase 2	psilocybin	—
Clinical Trial of MDMA-Assisted Therapy for Military Service Members With Posttraumatic Stress DisorderNCT07704762 · U.S. Army Medical Research and Development Command	Not yet recruiting	Phase 2	mdma	—
MDMA Plus Exposure Therapy for PTSDNCT05746572 · Emory University	Enrolling by invitation	Phase 2	mdma	1
Psilocybin-Assisted TherapyNCT07332143 · Emory University	Not yet recruiting	Phase 2	psilocybin	1
Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002NCT06816433 · Global Coalition for Adaptive Research	Suspended	Phase 2	ketamine	9
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner ViolenceNCT06885996 · University of Calgary	Not yet recruiting	Phase 2	psilocybin	2
MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers and First RespondersNCT05455996 · Nautilus Sanctuary	Not yet recruiting	Phase 2	mdma	3
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress DisorderNCT05554094 · Ohio State University	Active, not recruiting	Phase 2	psilocybin	1
Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)NCT06795659 · The University of Texas Health Science Center at San Antonio	Completed	Phase 1 / Phase 2	ketamine	1
Trifecta Research StudyNCT06810765 · Johns Hopkins University	Withdrawn	Phase 2	dmt, ibogaine	1
MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSDNCT04264026 · VA Loma Linda Health Care System	Completed	Phase 2	mdma	1
Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSDNCT04784143 · Resilient Pharmaceuticals	Terminated	Phase 2	mdma	1
The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderNCT05312151 · COMPASS Pathways	Completed	Phase 2	psilocybin	3
Group MDMA-therapy for Veterans With PTSDNCT05961527 · Portland VA Research Foundation, Inc	Completed	Phase 1 / Phase 2	mdma	1
Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSDNCT03282123 · Resilient Pharmaceuticals	Completed	Phase 2	mdma	12
MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in AdolescentsNCT06353282 · University of California, Los Angeles	Withdrawn	Phase 2	mdma	1
Open Label Study of MDMA-assisted Psychotherapy for Treatment of PTSD With Optional fMRI Sub-StudyNCT04030169 · MAPS Europe B.V.	Completed	Phase 2	mdma	6
A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD)NCT05067244 · Remedy	Completed	Phase 2	mdma	1
Study of Feasibility and Safety of MDMA-Assisted Group Therapy for the Treatment of PTSD in VeteransNCT05173831 · Resilient Pharmaceuticals	Withdrawn	Phase 2	mdma	—
Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSDNCT04889664 · Icahn School of Medicine at Mount Sinai	Completed	Phase 2	ketamine	1
Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSDNCT06036511 · University of New Mexico	Withdrawn	Phase 1 / Phase 2	ketamine	1
Ketamine Treatment for PTSD and MDD in TBINCT06228391 · Minneapolis Veterans Affairs Medical Center	Not yet recruiting	Phase 2	ketamine	1
Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSDNCT06141876 · Apex Labs Ltd.	Unknown status	Phase 2	psilocybin	—
MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress DisorderNCT05709353 · University of Sydney	Unknown status	Phase 2	mdma	2
Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress DisorderNCT05243329 · Halucenex Life Sciences Inc.	Unknown status	Phase 2	psilocybin	1
Evaluation of Psilocybin-assisted Psychotherapy (PaP) for the Treatment of Post-traumatic Stress Disorder (PTSD) in Military VeteransNCT05876481 · Combat Stress	Unknown status	Phase 2	psilocybin	1
Ketamine and Epigenetic AgingNCT05294835 · TruDiagnostic	Unknown status	Phase 2	ketamine	1
Combined Ketamine and eCBT Intervention for PTSDNCT04771767 · Queen's University	Unknown status	Phase 2	ketamine	1
CAP-Ketamine for Antidepressant Resistant PTSDNCT02655692 · VA Office of Research and Development	Completed	Phase 2	ketamine	3
Ketamine and Prolonged Exposure in PTSDNCT03960658 · Minneapolis Veterans Affairs Medical Center	Completed	Phase 1 / Phase 2	ketamine	1
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)NCT00749203 · Dennis Charney	Completed	Phase 2	ketamine	1
Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSDNCT07275970 · Scottsdale Research Institute	Active, not recruiting	Phase 1	psilocybin	1
A Study of Psilocybin for PTSDNCT06407635 · Johns Hopkins University	Active, not recruiting	Phase 1	psilocybin	1
The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD.NCT03752918 · Yale University	Withdrawn	Phase 1	mdma	1
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot TrialNCT03367533 · Yale University	Completed	Phase 1	ketamine	1
Safety and Tolerability of Psilocybin in Post-Traumatic Stress DisorderNCT05562973 · Johns Hopkins University	Withdrawn	Phase 1	psilocybin	—
Open-Label Dose-Ranging Study of Oral SM-001 in Healthy AdultsNCT05894902 · Advanced Integrative Medical Science Institute	Unknown status	Phase 1	dmt	1
Effect of Ketamine and Etomidate During RSI on Long Term OutcomesNCT06179485 · Vanderbilt University Medical Center	Enrolling by invitation	N/A	ketamine	6
Trifecta Research StudyNCT07717866 · Axial Therapeutic Research	Active, not recruiting	N/A	dmt, ibogaine	1
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic PsychedelicsNCT06624137 · Yale University	Terminated	N/A	lsd, psilocybin, dmt	2
Imaging SV2A in Mood DisordersNCT02734602 · Yale University	Active, not recruiting	Not applicable	ketamine	1
Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot StudyNCT07614581 · Adriaan Dirk van der Wart	Not yet recruiting	N/A	ketamine	1
Retrospective Observational Study of Intensity Effects in Psychedelic-assisted TreatmentNCT07164287 · University Hospital, Geneva	Active, not recruiting	N/A	lsd, psilocybin	1
Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)NCT05565352 · Medical University of Gdansk	Enrolling by invitation	N/A	ketamine	1
A Multi-site Expanded Access Program for MDMA-assisted Psychotherapy for Patients With Treatment-resistant PTSDNCT04438512 · Resilient Pharmaceuticals	No longer available	N/A	mdma	2
Long-Term Safety and Effectiveness of MDMA-Assisted Therapy for PTSDNCT05066282 · Resilient Pharmaceuticals	Completed	N/A	mdma	4
Chart Review of Patients Undergoing Ketamine InfusionsNCT04209296 · Brain and Cognition Discovery Foundation	Completed	N/A	ketamine	1
Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces CohortNCT05855876 · Stella Center	Unknown status	N/A	ketamine	1
Perceptions of MDMA-Assisted Therapy Among Veterans With PTSDNCT05895318 · Albany Research Institute, Inc.	Completed	N/A	mdma	1
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related PainNCT04057989 · Defense and Veterans Center for Integrative Pain Management	Completed	N/A	ketamine	1
PET Imaging of mGLuR5 With Drug ChallengeNCT01691092 · Yale University	Completed	Not applicable	ketamine	3
TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSDNCT02766192 · The Cooper Health System	Unknown status	Not applicable	ketamine	1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.