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Active, not recruitingPhase 4

Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression

NCT06317636 · PEAK · Stanford University

Closed to entry
Status
Not accepting participants
Phase 4
Phase
40
Target enrolment
1
Study sites
1 US states

What it is testing

Summary

The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during IV sedation in adults with chronic pain and depression. We do not know whether ketamine will be more effective than placebo under these circumstances. This study aims to: * Evaluate whether placebo is non-inferior to ketamine in treating chronic pain and depression, when delivered under propofol sedation * Confirm that propofol sedation is a safe way to keep participants blinded to treatment * Assess patients' comfort with the sedation process to improve future studies * Explore whether patient expectations affects their pain and depression Participants will: * Need to qualify for the study based on stringent medical criteria * Undergo sedation with propofol * Randomly receive either a ketamine or a placebo (saline) infusion during sedation * Complete several study assessments over 5-7 weeks

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Pain intensity in the past 24 hours

    Measured over screening; 1, 7, 14, 21 and 28 days after treatment

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 70 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Age 18 to 70 years old * Comfortable speaking and writing in English * Chronic pain present daily for at least 3 months * Currently experiencing depression * Able to comply with the study protocol and communicate with study personnel about adverse events and other clinically important information Exclusion Criteria: * Pregnant or breastfeeding * One or more health conditions that makes study unsafe or unfeasible, determined by study physicians * Regular use of medications that may have problematic interactions with the study drugs * Participating in another clinical trial which may conflict with this one

Where

1 study site

FacilityCityRegionCountry
Stanford UniversityStanfordCaliforniaUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT06317636 on ClinicalTrials.gov →

Last updated in the registry 2025-10-02. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

Recruiting in

All 10 trials from Stanford University →