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CompletedPhase 2Results posted

Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)

NCT02062658 · New York State Psychiatric Institute

Closed to entry
Status
Not accepting participants
Phase 2
Phase
10
Target enrolment
1
Study sites
1 US states

What it is testing

Summary

This study investigates if a single dose of IV Ketamine can rapidly improve Obsessive-Compulsive Disorder (OCD) symptoms and whether these effect can be maintained with a condensed course of a type of Cognitive Behavioral Therapy called Exposure and Response Prevention (EX/RP). You will be compensated for your time and travel. Participants must be between the ages of 18-55.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Number of Patients Who Met and Exceeded Response Criteria of Yale-Brown Obsessive-Compulsive Scale

    Measured over 2 weeks

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 55 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Age 18-55 * Physically healthy and not currently pregnant * Primary Diagnosis of OCD * Sufficient severity of symptoms * Currently off all psychotropic medication OR * Currently on adequate dose of medication for treatment of OCD, but have not achieved at least partial remission * Able to provide consent Exclusion Criteria: * Psychiatric conditions that make participation unsafe (schizophrenia \[either self or first degree relative e.g. siblings, parents\], history of violence, severe depression, eating disorder, substance dependence \[including nicotine\]) * Female patients who are either pregnant or nursing * Planning to commence EX/RP during the period of the study or those who have completed an adequate dose of EX/RP (defined as 8 or more sessions within 2 months) within 8 weeks prior to enrollment. period of the study * Allergy to ketamine * Participants for whom being off of medication is not clinically recommended * Medical conditions that make participation unsafe (e.g. high blood pressure, head injury) * Currently on medications that make participation unsafe

Where

1 study site

FacilityCityRegionCountry
New York State Psychiatric InsituteNew YorkNew YorkUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT02062658 on ClinicalTrials.gov →

Last updated in the registry 2016-12-29. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

Recruiting in

All 12 trials from New York State Psychiatric Institute →