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CompletedPhase 4

Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department

NCT04266288 · MercyOne Des Moines Medical Center

Closed to entry
Status
Not accepting participants
Phase 4
Phase
29
Target enrolment
1
Study sites
1 US states

What it is testing

Summary

The purpose of this study is to examine the effect of a low-dose ketamine infusion on depression symptoms within the Emergency Department (ED) visit, and healthcare utilization after leaving the ED, when administered in the ED for depression or suicidal ideation.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Depression Symptom Response

    Measured over Baseline, 4 hours

  • ED Return Visit

    Measured over 30 days from discharge

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Adults 18 years of age and older * Presenting to the ED with a chief complaint of severe depression or suicidality, or presenting to the ED with any other chief complaint but answering "yes" to "Thoughts of harming/killing yourself?" during intake/triage Exclusion Criteria: * Acute mania or psychosis * Enrollment in trial during a prior emergency department visit * History of ketamine abuse or dependence * Known hypersensitivity to ketamine * Acute intoxication with any drug of abuse (including alcohol) * Pregnancy or lactation * Any condition that would place the patient at serious risk of harm from an increase in blood pressure (e.g. history of intracerebral hemorrhage, aneurysmal vascular disease, or arteriovenous malformation) * Assessing provider does not want to enroll patient for any other reason, based on their clinical judgement

Where

1 study site

FacilityCityRegionCountry
MercyOne Des Moines Medical CenterDes MoinesIowaUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT04266288 on ClinicalTrials.gov →

Last updated in the registry 2020-09-01. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

Recruiting in