RecruitingNot applicable

Dexmedetomidine and Ketamine in VATS Surgery

NCT03596424 · Ciusss de L'Est de l'Île de Montréal

Recruiting

Status

Accepting participants

Not applicable

Phase

120

Target enrolment

Study sites

Outside the US

What it is testing

Summary

Postoperative pain after VATS surgery is significant and associated with moderate to high post operative morphine requirements, which can cause opioid related side effects and delay postoperative recovery. To reduce this requirement, multimodal analgesia with non opioid medication such as dexmedetomidine and ketamine can be used. These drugs have demonstrated significant opioid-sparing properties after various types of surgeries. However, very little is known about their ability to do so in VATS surgery. Also, their relative opioid-sparing properties have not been compared, and it is not known whether their combined use can lead to an additional opioid-sparing effect. The primary goal of this study will be to determine the impact of a combined intra operative infusion of ketamine and dexmedetomidine on postoperative morphine requirements in patients undergoing elective VATS, compared to both these drugs infused separately. The hypothesis is that this combined infusion will lead to a 30% further reduction in morphine requirements, 24h after surgery, compared to both these drugs infused separately.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

Day 1 Postoperative morphine requirement
Measured over Day 1

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 80 Years

Ages

All

Sex

Not accepted

Healthy volunteers

Inclusion Criteria: * Patients aged 18-80 years old * American Society of Anesthesiology physical status I-III * Elective Video-Assisted Thoracic Surgery for pulmonary resection Exclusion Criteria: * Patients for which a regional anesthesia technique is planned for postoperative analgesia. * Patients taking beta-blockers preoperatively. * Patients with chronic pain taking \>60 mg morphine PO daily (or its equivalent). * Patients taking pregabalin, gabapentin, amitryptillin, nortryptillin and/or duloxetin. * Documented allergy to ketamine and/or dexmedetomidine. * Pregnancy * Inability to give informed consent * Linguistic barrier. * Patient refusal

Where

1 study site

Facility	City	Region	Country
Ciusss	Montreal	Quebec	Canada

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT03596424 on ClinicalTrials.gov →

Last updated in the registry 2024-12-02. Registry records change; this page reflects the data build of 2026-08-25.

Where this trial sits

Substance

Ketamine

Indication