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Unknown statusPhase 4

Clinical Trial of the Use of Ketamine in Treatment Resistant Depression

NCT02610712 · National Institute of Neurology and Neurosurgery, Mexico

Closed to entry
Status
Not accepting participants
Phase 4
Phase
20
Target enrolment
1
Study sites
Outside the US

What it is testing

Summary

The purpose of this study is to determine the efficacy of the use of intravenous low-dose ketamine in the treatment of treatment-resistant depression (TRD), as well as the changes in Glutamate neurotransmission and inflammatory serum markers.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Hamilton Depression Rating Scale (HDRS) Score

    Measured over Change from baseline HDRS Score at 24 hours

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 65 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Treatment-Resistant Depression (Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies) * Acceptance of participation via the informed consent Exclusion Criteria: * Psychiatric comorbidity (except anxiety related disorders) * Substance abuse or dependence in the previous 3 months * Evidence of structural abnormalities in brain imaging * Pregnancy * Previous hypersensitivity to ketamine * Heart failure or insufficiency * Familial or personal history of psychosis * Glaucoma * Major neurological disease * Uncontrolled systemic arterial hypertension * MRI contraindications * Non-acceptance of participation via informed consent

Where

1 study site

FacilityCityRegionCountry
National Institute of Neurology and NeurosurgeryMexico CityMexico CityMexico

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT02610712 on ClinicalTrials.gov →

Last updated in the registry 2016-09-21. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

All 2 trials from National Institute of Neurology and Neurosurgery, Mexico →