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Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol

NCT05242081 · The First Affiliated Hospital with Nanjing Medical University

Closed to entry
Status
Not accepting participants
Not applicable
Phase
980
Target enrolment
1
Study sites
Outside the US

What it is testing

Summary

The purpose of this study was to observe the effects of opioid-free anesthesia with S-ketamine on postoperative analgesia and perioperative hemodynamics in short surgical operations, and to explore the effects of S-ketamine on postoperative awakening time and extubation time, nausea and vomiting, hypoxemia, and delirium.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • The probability of numerical rating scale (NRS) score being less than or equal to 3 when leaving the Postanesthesia Care Unit (PACU)

    Measured over 1 day of the surgery

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 65 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: 1. Aged from 18 years to 65 years 2. American society of anesthesiologists physical status classification I-II 3. Patients scheduled for elective laparoscopic cholecystectomy 4. Willing to sign informed consent Exclusion Criteria: 1. Allergic to narcotic drugs; 2. Surgical history within the past 1 month; 3. patients with neurological diseases or mental disorders; 4. Unable to understand numerical rating Scale (NRS); 5. patients with untreated or poorly controlled hypertension (arterial hypertension, resting systolic/diastolic blood pressure over 180/100mmHg); 6. patients with untreated or undertreated hyperthyroidism; 7. Patients with unstable angina pectoris or myocardial infarction in the past 6 months; 8. When intraocular pressure is high (glaucoma) and penetrating ocular trauma, intraocular pressure cannot rise.

Where

1 study site

FacilityCityRegionCountry
The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT05242081 on ClinicalTrials.gov →

Last updated in the registry 2022-07-20. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance