Indication

Anxiety

31 registered trials testing LSD, Psilocybin, MDMA, Ketamine for this indication, 7 recruiting now.

Registered trials

Recruiting

In Phase 3

Substances tested

Being studied with

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When a new trial opens

Trials

All 31 trials for Anxiety

Trial	Status	Phase	Substance	Sites
IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric EDNCT05934669 · University of Oklahoma	Recruiting	Phase 4	ketamine	1
Psilocybin-Assisted Therapy for Intergenerational TraumaNCT06899165 · Rachel Yehuda	Recruiting	Phase 2	psilocybin	1
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer SurvivorsNCT06801041 · M.D. Anderson Cancer Center	Recruiting	Phase 2	psilocybin	1
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and AnxietyNCT06820723 · Ohio State University	Recruiting	Phase 2	psilocybin	1
Lysergic Acid Diethylamide (LSD) in Palliative CareNCT05883540 · University Hospital, Basel, Switzerland	Recruiting	Phase 2	lsd	4
Open-Label Psilocybin Study in Transdiagnostic PopulationNCT06442423 · Yale University	Recruiting	Phase 1	psilocybin	1
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant DepressionNCT07146503 · Riccardo Guglielmo	Recruiting	N/A	ketamine	5
Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral ReconstructionNCT07753772 · Peking University First Hospital	Not yet recruiting	Phase 4	ketamine	1
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health	Completed	Phase 4	ketamine	11
Clinical Study of Oral Midazolam Combined With Esketamine Administered Intranasally for Pediatric Preoperative SedationNCT05925283 · Second Affiliated Hospital of Wenzhou Medical University	Unknown status	Phase 4	ketamine	1
Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department PatientsNCT03043430 · Brooke Army Medical Center	Terminated	Phase 4	ketamine	1
A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn PatientsNCT02336308 · University of Colorado, Denver	Withdrawn	Phase 4	ketamine	1
Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic MalignanciesNCT07336238 · University of Washington	Active, not recruiting	Phase 2	psilocybin	1
Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of DepressionNCT07565909 · University of Washington	Not yet recruiting	Phase 2	psilocybin	—
MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening IllnessNCT02427568 · Resilient Pharmaceuticals	Completed	Phase 2	mdma	1
Effects of Psilocybin in Advanced-Stage Cancer Patients With AnxietyNCT00302744 · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	Completed	Phase 1 / Phase 2	psilocybin	1
Psilocybin Therapy for Depression and Anxiety in Parkinson's DiseaseNCT04932434 · Joshua Woolley, MD, PhD	Completed	Phase 2	psilocybin	1
Psilocybin-assisted Therapy for Alcohol Use DisorderNCT06444243 · University of Sydney	Unknown status	Phase 2	psilocybin	—
Psilocybin-Assisted Psychotherapy for Anxiety in People With Stage IV MelanomaNCT00979693 · Multidisciplinary Association for Psychedelic Studies	Withdrawn	Phase 2	psilocybin	1
Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related AnxietyNCT00920387 · Multidisciplinary Association for Psychedelic Studies	Completed	Phase 2	lsd	1
Psychopharmacology of Psilocybin in Cancer PatientsNCT00465595 · Johns Hopkins University	Completed	Phase 2	psilocybin	1
Oral Ketamine in the Treatment of Depression and Anxiety in Patients With CancerNCT01680172 · Mayo Clinic	Terminated	Phase 2	ketamine	2
Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic CancerNCT05086250 · Cedars-Sinai Medical Center	Completed	Early Phase 1	ketamine	1
Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer PatientsNCT06665568 · University of Zurich	Not yet recruiting	Early Phase 1	ketamine	1
Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI CancersNCT06001372 · University of Utah	Terminated	Early Phase 1	ketamine	1
Mood and Cognitive Effects of Psilocybin in Healthy ParticipantsNCT05252598 · Optimi Health Corporation	Withdrawn	Early Phase 1	psilocybin	—
Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe DepressionNCT07374198 · Chinese PLA General Hospital	Not yet recruiting	Not applicable	ketamine	—
Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe DepressionNCT07374211 · Chinese PLA General Hospital	Not yet recruiting	Not applicable	ketamine	—
Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer SurgeryNCT07367542 · Chinese PLA General Hospital	Not yet recruiting	Not applicable	ketamine	1
Correlates of Anxiety Associated With a Life-threatening IllnessNCT02954562 · Resilient Pharmaceuticals	Completed	N/A	mdma	1
Pediatric Laser Acupuncture and Renal BiopsyNCT01879826 · University of California, San Francisco	Completed	Not applicable	ketamine	2

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.