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Unknown statusPhase 4

Ketamine Co-induction for Patients With Major Depressive Disorder

NCT03666494 · University of Saskatchewan

Closed to entry
Status
Not accepting participants
Phase 4
Phase
50
Target enrolment
—
Study sites

What it is testing

Summary

Ketamine hydrochloride, an anesthetic medication, has been demonstrated to acutely and rapidly improve depressive symptoms but not yet been adequately studied for this effect when used as part of a general anesthetic for surgery. This proposed single-centre, double-blinded, randomized clinical trial of adult patients with depression presenting for gynecologic surgery would compare severity of depressive symptoms between patients receiving and not receiving ketamine as part of their general anesthetic.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Depression Severity

    Measured over At time of discharge from post-anesthetic care unit, until 3 hours post operatvie

  • Depression Severity

    Measured over 72 hours post-operative

  • Depression Severity

    Measured over 7-days post-operative

  • Depression Severity

    Measured over 30-days post-operative

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 65 Years
Ages
FEMALE
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Diagnosis of major depressive disorder * Presentation for gynecologic surgery requiring a general anesthetic Exclusion Criteria: * Marked co-morbid cardiovascular disease * Marked co-morbid respiratory disease * History of intracranial hypertension * History of seizures * ASA Physical Status Classification IV or greater * History of psychosis * Current pregnancy * Contraindication to ketamine administration

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT03666494 on ClinicalTrials.gov →

Last updated in the registry 2018-09-13. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

Indication

All 4 trials from University of Saskatchewan →