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Indication

Unipolar Depression

14 registered trials testing Psilocybin, Ketamine, DMT for this indication, 1 recruiting now.

Sponsors register this under 2 different names, all collected here: Depression, Unipolar · Unipolar Depression

14
Registered trials
1
Recruiting
2
In Phase 3

Substances tested

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Trials

All 14 trials for Unipolar Depression

TrialStatusPhaseSubstanceSites
Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung CancerNCT07216404 · Alan DavisRecruitingPhase 2psilocybin1
IM Ketamine vs Midazolam for Suicidal ER PatientsNCT04640636 · New York State Psychiatric InstituteSuspendedPhase 4ketamine1
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in DepressionNCT01881763 · Northwell HealthCompletedPhase 4ketamine1
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.NCT03156504 · Mayo ClinicCompletedPhase 4ketamine4
Ketamine As an Adjunctive Therapy for Major Depression (2)NCT04939649 · University of Dublin, Trinity CollegeCompletedPhase 3ketamine1
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)NCT03113968 · Bo HuCompletedPhase 2 / Phase 3ketamine5
Repeated Neurocognitive Measurements in Depressed PatientsNCT05991232 · Jay FournierWithdrawnPhase 1 / Phase 2ketamine1
Repeated Neurocognitive Measurements in Depressed PatientsNCT04916548 · Rebecca PriceCompletedPhase 1 / Phase 2ketamine1
Ketamine + Mindfulness for DepressionNCT05168735 · Rebecca PriceCompletedPhase 1 / Phase 2ketamine1
Safety, Tolerability and Antidepressant Effects of DMT in Patients With DepressionNCT06094907 · Universidade Federal do Rio Grande do NorteCompletedPhase 2dmt1
Ketamine Trial for the Treatment of DepressionNCT02401139 · The University of New South WalesCompletedPhase 1ketamine2
Ketamine as an Adjunctive Therapy for Major DepressionNCT03256162 · St Patrick's Hospital, IrelandCompletedPhase 1ketamine1
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in DepressionNCT04701866 · Douglas Mental Health University InstituteCompletedNot applicableketamine2
The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)NCT04399070 · Yan QiuUnknown statusNot applicableketamine1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.