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Ketamine Anesthesia for Improvement of Depression in ECT

NCT02752724 · KAID · VA Puget Sound Health Care System

Closed to entry
Status
Not accepting participants
Not applicable
Phase
52
Target enrolment
1
Study sites
1 US states

What it is testing

Summary

The purpose of this prospective randomized clinical trial is to determine if patients receiving ketamine as a part of general anesthesia during electroconvulsive therapy (ECT) rather than standard of care will have improvement in symptoms of depression after a course of ECT treatments. The investigators hypothesize that utilization of ketamine for induction of general anesthesia during ECT treatments will improve symptoms of depression better than standard care. This study is ONLY open to patients eligible to receive healthcare services through the Department of Veterans Affairs at the VA Puget Sound, which means service in the active military, naval or air service or separation under any condition other than dishonorable. Qualifications for VA health care benefits can be found at va.gov.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Change in Depression Patient Health Questionnaire 9 (PHQ9) Scoring

    Measured over Change from Baseline Score 24 hours prior to starting ECT to PHQ9 score 72 hours following last ECT session

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 100 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * outpatients or inpatients at the Puget Sound VA with diagnosis of major depressive disorder or bipolar 1 or 2 over the age of 18 undergoing index course ECT Exclusion Criteria: * uncontrolled hypertension (blood pressure \> 180/90 mmHg at the pre-anesthesia clinic visit) * renal failure * neurologic disorders (e.g. epilepsy, space occupying lesions, traumatic brain injuries in the past 6 months) * myocardial infarction in the past 6 months * known allergies or adverse reactions to ketamine * American Society of Anesthesiology Physical Class greater than 3 * concomitant psychosis * schizophrenia or current abuse of alcohol or illicit substances and pregnancy (any trimester)

Where

1 study site

FacilityCityRegionCountry
VA Puget Sound Health Care SystemSeattleWashingtonUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT02752724 on ClinicalTrials.gov →

Last updated in the registry 2018-06-06. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits

Substance

Recruiting in