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Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort

NCT05855876 · Stella Center

Closed to entry
Status
Not accepting participants
Not applicable
Phase
20
Target enrolment
1
Study sites
1 US states

What it is testing

Summary

The purpose of this study is to examine measures of GrimAge clock in SOF members undergoing treatment for PTSD/TBI using CSB.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Change from baseline in Epigenetic Aging at 15 days

    Measured over day 15

  • Change from baseline in Epigenetic Aging at 90 days

    Measured over day 90

  • Change from baseline in Epigenetic Aging at 180 days

    Measured over day 180

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

40 Years to 60 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Recruited from SOF with an active duty history of at least 5 years. * Subjects may be in active duty or retired, male and female, between the ages of 40 and 60 years old. * The participants must have a confirmed diagnosis of PTSD, identified by Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) scores higher than 40. * The participants must have been on a stable pharmacological or psychotherapeutic therapy for at least three months (if applicable), and continue this treatment throughout the duration of the study. * They must be able and willing to consent for the study. Individuals who are able to become pregnant must adhere to a medically accepted method of contraception (eg. hormonal birth control, barrier birth control, intrauterine device, abstinence). Exclusion Criteria: * Existing Horner syndrome; * Allergy to local anesthetics or contrast; * Previous history of stellate ganglion block with psychosis; * Admission to in-patient psychiatric facility within last 3 months; * History of moderate of severe TBI; * Currently pregnant or breastfeeding; * Current substance use disorder, or test positive for 1 or more illegal or controlled drugs on the initial urine drug screen, such as cocaine, marijuana, amphetamines, opioids, benzodiazepines, amongst others; * Previous behavioral health diagnoses (bipolar I, psychosis, etc); * Currently undergoing exposure therapy.

Where

1 study site

FacilityCityRegionCountry
Stella CenterWestmontIllinoisUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT05855876 on ClinicalTrials.gov →

Last updated in the registry 2023-07-17. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits