| Positioning of Esketamine Treatment in the Real-world Management of DepressionNCT06103760 · Royal North Shore Hospital | Recruiting | Phase 4 | ketamine | 1 |
| Esketamine Versus Crisis Response Planning Versus Optimized Treatment as Usual for Suicide Prevention: A Pragmatic Controlled Trial in Two Brazilian CitiesNCT07120477 · University of Sao Paulo | Recruiting | Phase 4 | ketamine | 1 |
| Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm RepairNCT04894864 · University of Crete | Recruiting | Phase 4 | ketamine | 1 |
| Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant DepressionNCT06278779 · The George Institute | Recruiting | Phase 4 | ketamine | 7 |
| Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma PatientsNCT06903819 · Texas Tech University Health Sciences Center | Recruiting | Phase 4 | ketamine | 2 |
| Esketamine With or Without Integration Therapy for Treatment-Resistant DepressionNCT07369102 · University of Puerto Rico | Recruiting | Phase 4 | ketamine | 2 |
| Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With DepressionNCT05450432 · Massachusetts General Hospital | Recruiting | Phase 4 | ketamine | 1 |
| Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General AnesthesiaNCT06853431 · Second Affiliated Hospital of Wenzhou Medical University | Recruiting | Phase 4 | ketamine | 2 |
| Neural Circuit Effects of Ketamine in DepressionNCT06213324 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 4 | ketamine | 1 |
| Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECTNCT05655754 · Medical University of Vienna | Recruiting | Phase 4 | ketamine | 1 |
| Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.NCT06774274 · Universidad de Antioquia | Recruiting | Phase 4 | ketamine | 1 |
| The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSDNCT06414356 · Margaux M. Salas, PhD | Recruiting | Phase 4 | ketamine | 1 |
| ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant DepressionNCT03272698 · University of Saskatchewan | Recruiting | Phase 4 | ketamine | 1 |
| IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric EDNCT05934669 · University of Oklahoma | Recruiting | Phase 4 | ketamine | 1 |
| Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderNCT07570654 · COMPASS Pathways | Recruiting | Phase 2 / Phase 3 | psilocybin | 1 |
| A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited | Recruiting | Phase 3 | psilocybin | 68 |
| Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionNCT07226232 · VA Office of Research and Development | Recruiting | Phase 3 | psilocybin | 5 |
| The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive DisorderNCT06247839 · Sharmin Ghaznavi | Recruiting | Phase 3 | psilocybin | 1 |
| InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpressionNCT06781697 · Sunnybrook Health Sciences Centre | Recruiting | Phase 3 | ketamine | 1 |
| A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc. | Recruiting | Phase 3 | lsd | 30 |
| PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence StudyNCT06713616 · Yale University | Recruiting | Phase 3 | ketamine | 8 |
| A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive DisorderNCT07227454 · Janssen Research & Development, LLC | Recruiting | Phase 3 | ketamine | 35 |
| A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant DepressionNCT07716098 · Janssen Research & Development, LLC | Recruiting | Phase 3 | ketamine | 4 |
| Ketamine Treatment of Youth Suicide AttemptersNCT04763343 · Tatiana Falcone, MD | Recruiting | Phase 3 | ketamine | 1 |
| Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive DisorderNCT07703722 · Khyber Medical University Peshawar | Recruiting | Phase 3 | psilocybin | 3 |
| Psilocybin Microdose for Psychological and Existential Distress in Palliative Care (PSYCHED-PAL-RCT)NCT07063862 · Bruyère Health Research Institute. | Recruiting | Phase 3 | psilocybin | 7 |
| Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive SymptomsNCT07638553 · Centre Hospitalier Universitaire de Nīmes | Recruiting | Phase 3 | psilocybin | 8 |
| MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use DisorderNCT07118839 · VA Office of Research and Development | Recruiting | Phase 2 / Phase 3 | mdma | 2 |
| Understanding and Treating Suicidal Ideation With KetamineNCT06891300 · The Royal's Institute of Mental Health Research | Recruiting | Phase 2 / Phase 3 | ketamine | 1 |
| Ketamine Augmentation of ECT in Treatment-Resistant DepressionNCT07088380 · Università Vita-Salute San Raffaele | Recruiting | Phase 3 | ketamine | 1 |
| MDMA-assisted Massed Prolonged Exposure for PTSDNCT06117306 · Healing Breakthrough | Recruiting | Phase 3 | mdma | 1 |
| Nebulized Ketamine for the Treatment of Major Depressive DisorderNCT06752759 · Theresa Jacob, PhD, MPH | Recruiting | Phase 3 | ketamine | 1 |
| Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureNCT05603104 · Dr. Inge Winter | Recruiting | Phase 3 | ketamine | 1 |
| Psilocybin Therapy in Advanced CancerNCT05398484 · NYU Langone Health | Recruiting | Phase 2 / Phase 3 | psilocybin | 2 |
| The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.NCT05973851 · Dr. Inge Winter | Recruiting | Phase 3 | ketamine | 12 |
| Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression PatientsNCT06508710 · Assistance Publique - Hôpitaux de Paris | Recruiting | Phase 3 | ketamine | 4 |
| Ketamine & Crisis Response Plan for Suicidal Ideation in the EDNCT05696691 · The University of Texas Health Science Center at San Antonio | Recruiting | Phase 2 / Phase 3 | ketamine | 1 |
| Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral InjuryNCT06394284 · Herzog Hospital | Recruiting | Phase 3 | mdma | 1 |
| Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant DepressionNCT07211438 · Centre for Addiction and Mental Health | Recruiting | Phase 2 | psilocybin | 2 |
| MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress DisorderNCT05790239 · Stephen Robert Marder | Recruiting | Phase 2 | mdma | 2 |
| MDMA-Assisted CBCT for PTSD vs CBCT RCTNCT06044675 · Remedy | Recruiting | Phase 2 | mdma | 1 |
| Neurobiology of SuicideNCT02543983 · National Institute of Mental Health (NIMH) | Recruiting | Phase 2 | ketamine | 1 |
| Safety, Therapeutic Potential, and Mechanisms of Two Psilocybin Doses, Administered With Psychological Support in Young Adults With Anorexia NervosaNCT07169747 · Region Skane | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin-Assisted Therapy for Intergenerational TraumaNCT06899165 · Rachel Yehuda | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance TherapyNCT06200155 · M.D. Anderson Cancer Center | Recruiting | Phase 2 | psilocybin | 1 |
| Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUDNCT06349083 · NYU Langone Health | Recruiting | Phase 2 | psilocybin | 1 |
| Pilot Study of RR-HNK in OCDNCT06575075 · Carolyn Rodriguez | Recruiting | Phase 1 / Phase 2 | ketamine | 1 |
| Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and SuicidalityNCT06706232 · The University of Texas Health Science Center, Houston | Recruiting | Phase 2 | psilocybin | 1 |
| TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer SurvivorsNCT06801041 · M.D. Anderson Cancer Center | Recruiting | Phase 2 | psilocybin | 1 |
| Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety DisorderNCT06969170 · Claudio N Soares | Recruiting | Phase 2 | psilocybin | 1 |
| Investigation to Understand and Optimize PsilocybinNCT06512194 · Charles Raison | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin to Treat Depression in Spinal Cord InjuryNCT07251491 · James J. Peters Veterans Affairs Medical Center | Recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| Psilocybin Therapy for Depression in Parkinson's DiseaseNCT06455293 · Joshua Woolley, MD, PhD | Recruiting | Phase 2 | psilocybin | 1 |
| Mindfulness-Assisted Psychedelic TherapyNCT06233344 · University of Southern California | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin in Cancer Pain StudyNCT06001749 · Yvan Beaussant, MD, MSci | Recruiting | Phase 2 | psilocybin | 1 |
| Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical TrialNCT07747324 · University of Sao Paulo | Recruiting | Phase 1 / Phase 2 | dmt | 1 |
| Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)NCT06512220 · Centre for Addiction and Mental Health | Recruiting | Phase 2 | psilocybin | 1 |
| Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)NCT06518720 · Centre for Addiction and Mental Health | Recruiting | Phase 2 | psilocybin | 1 |
| Ecstasy to Alleviate SEvere Chronic Neuropathic Pain TrialNCT07301632 · Unity Health Toronto | Recruiting | Phase 2 | mdma | 1 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)NCT07569198 · Joshua Rosenblat | Recruiting | Phase 2 | ketamine | 1 |
| Effects of Psilocybin on Electrophysiology and the Dynamic Content of ThoughtNCT05301608 · Johns Hopkins University | Recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and AnxietyNCT06820723 · Ohio State University | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin-Assisted Therapy for Physician Well-Being and BurnoutNCT06814522 · University of California, San Diego | Recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| Psilocybin Efficacy With or Without Pimavanserin PretreatmentNCT07610135 · Johns Hopkins University | Recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| The Efficacy of Psilocybin Therapy for Depression in Parkinson's DiseaseNCT07610369 · Yale University | Recruiting | Phase 2 | psilocybin | 1 |
| Tolerability of MDMA in SchizophreniaNCT05770375 · Anya Bershad, MD, PhD | Recruiting | Phase 1 / Phase 2 | mdma | 1 |
| Outpatient Buprenorphine Induction With Psilocybin for Opioid Use DisorderNCT06067737 · Johns Hopkins University | Recruiting | Phase 2 | psilocybin | 1 |
| Inhaled DMT for Major Depressive DisorderNCT07562191 · Universidade Federal do Rio Grande do Norte | Recruiting | Phase 2 | dmt | 5 |
| Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionNCT06511908 · National Institute of Mental Health (NIMH) | Recruiting | Phase 2 | ketamine | 1 |
| Psilocybin on Brain Mechanisms of Motivation in OUDNCT06810310 · University of Pennsylvania | Recruiting | Phase 2 | psilocybin | 1 |
| Preliminary Effectiveness of Individual and Group MDMA-assisted Therapy for Israeli Veterans With PTSD and Moral Injury.NCT05732155 · HaEmek Medical Center, Israel | Recruiting | Phase 2 | mdma | 1 |
| Psilocybin-Assisted Therapy for Sexual Assault-Related PTSDNCT06902974 · Sunstone Medical | Recruiting | Phase 2 | psilocybin | 1 |
| MDMA Therapy in Veterans With PTSDNCT07569159 · Sunstone Medical | Recruiting | Phase 2 | mdma | 1 |
| 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use DisorderNCT05452772 · Johns Hopkins University | Recruiting | Phase 2 | psilocybin | 3 |
| Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSDNCT06386003 · Unity Health Toronto | Recruiting | Phase 2 | psilocybin | 1 |
| Mindfulness-based Psilocybin Therapy for PTSDNCT07104916 · Anthony P King | Recruiting | Phase 2 | psilocybin | 1 |
| Ketamine for Combined Depression and Alcohol Use DisorderNCT06090422 · University Hospital of North Norway | Recruiting | Phase 1 / Phase 2 | ketamine | 1 |
| Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Caregivers of Patients With Advanced CancerNCT07048743 · University Health Network, Toronto | Recruiting | Phase 2 | psilocybin | 1 |
| Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit PatientsNCT07639359 · Hospital Italiano de Buenos Aires | Recruiting | Phase 2 | ketamine | 2 |
| Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy VolunteersNCT06626139 · Robin Carhart-Harris, PhD, MA | Recruiting | Phase 2 | psilocybin | 1 |
| Subjective Experience Following PsilocybinNCT06768944 · University of Calgary | Recruiting | Phase 2 | psilocybin | 1 |
| MDMA-Assisted Massed Exposure Therapy for PTSDNCT07288151 · Emory University | Recruiting | Phase 2 | mdma | 1 |
| Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung CancerNCT07216404 · Alan Davis | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin Therapy for Psychological Distress in Palliative PatientsNCT06782724 · University Medical Center Groningen | Recruiting | Phase 2 | psilocybin | 4 |
| The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsNCT05786066 · Yale University | Recruiting | Phase 2 | ketamine | 1 |
| MDMA-assisted Therapy for Adjustment Disorder (AD) in Dyads of Patients With Cancer and a Concerned Significant OtherNCT05584826 · Sunstone Medical | Recruiting | Phase 2 | mdma | 1 |
| Ketamine Alcohol (in Treatment-Resistant Depression)NCT02122562 · Mark Niciu | Recruiting | Phase 2 | ketamine | 1 |
| Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSDNCT06608277 · Northwestern University | Recruiting | Phase 2 | ketamine | 3 |
| LSD Treatment for Persons With Alcohol Use DisorderNCT05474989 · Felix Mueller | Recruiting | Phase 2 | lsd | 2 |
| Lysergic Acid Diethylamide (LSD) in Palliative CareNCT05883540 · University Hospital, Basel, Switzerland | Recruiting | Phase 2 | lsd | 4 |
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)NCT05940324 · Stanford University | Recruiting | Phase 2 | ketamine | 1 |
| Cancer Related Major Depression Treated With a Single Dose of PsilocybinNCT06319378 · Section for Affective Disorders; Northern Stockholm Psychiatry | Recruiting | Phase 2 | psilocybin | 4 |
| A Phase 2A Trial of DT402 for Autism Spectrum DisorderNCT07303907 · Definium Therapeutics US, Inc. | Recruiting | Phase 2 | mdma | 1 |
| A Randomized Neuroimaging Trial of Psilocybin in DepressionNCT06072898 · Sunnybrook Health Sciences Centre | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory DepressionNCT06898606 · Federal University of Latin American Integration | Recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| MDMA for Co-occurring PTSD and OUD After ChildbirthNCT05219175 · University of New Mexico | Recruiting | Phase 2 | mdma | 1 |
| Ketamine for Opioid Use DisorderNCT06943859 · University of Maryland, Baltimore | Recruiting | Phase 2 | ketamine | 1 |
| Group vs Individual MDMA-Assisted Therapy for PTSD After the October 7, 2023 EventsNCT07469098 · Sheba Medical Center | Recruiting | Phase 2 | mdma | 2 |
| Imaging Depression in Parkinson's DiseaseNCT06402955 · Yale University | Recruiting | Phase 2 | ketamine | 1 |
| MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)NCT05783817 · Carolyn Rodriguez | Recruiting | Phase 2 | mdma | 1 |
| Study of Psilocybin for Anorexia in Young AdultsNCT06399263 · Marissa Raymond-Flesch, MD, MPH | Recruiting | Phase 2 | psilocybin | 2 |
| Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment DisorderNCT07072728 · Psyence Australia Pty Ltd | Recruiting | Phase 2 | psilocybin | 3 |
| RCT of Psilocybin-assisted CBT for DepressionNCT07281352 · University of California, Los Angeles | Recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| Psilocybin for Opioid Use Disorder (OUD)NCT06796062 · NYU Langone Health | Recruiting | Phase 2 | psilocybin | 5 |
| MDMA in Borderline Personality DisorderNCT06683014 · Yale University | Recruiting | Phase 2 | mdma | 1 |
| State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing TraumaNCT06888128 · Baylor College of Medicine | Recruiting | Phase 2 | psilocybin | 1 |
| A Study to Evaluate the Efficacy, Safety, and Pharmacokinetic Characteristics of (R)-Ketamine Hydrochloride Nasal Spray in Patients With Depression and Acute Suicidal Ideation or BehaviorNCT07193901 · Sichuan Purity Pharmaceutical Technology Co., Ltd. | Recruiting | Phase 2 | ketamine | 8 |
| Ayahuasca, Esketamine and PTSDNCT07317206 · University of Sao Paulo | Recruiting | Phase 2 | ketamine, dmt | 1 |
| Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid DepressionNCT06419439 · VA Office of Research and Development | Recruiting | Phase 2 | ketamine | 1 |
| i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical TrialNCT06480500 · University Health Network, Toronto | Recruiting | Phase 2 | ketamine | 1 |
| Ketamine and Neurofeedback as Combined Therapeutic Interventions to Target Glutamatergic Neurotransmission in Alcohol Use DisorderNCT06969937 · Dr. med. Marcus Herdener | Recruiting | Phase 2 | ketamine | 1 |
| Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid MedicationNCT05585229 · University of British Columbia | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator TrialNCT06405607 · University of Iowa | Recruiting | Phase 2 | psilocybin, ketamine | 1 |
| Psilocybin rTMS for Treatment Resistant DepressionNCT06132178 · University of Texas at Austin | Recruiting | Phase 2 | psilocybin | 1 |
| Pragmatic Trial of Psilocybin Therapy in Palliative CareNCT05403086 · Charles S. Grob, M.D. | Recruiting | Phase 2 | psilocybin, ketamine | 5 |
| Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCDNCT04882839 · Beersheva Mental Health Center | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin Microdosing With Psychotherapy for Treatment-Resistant DepressionNCT07183748 · Beersheva Mental Health Center | Recruiting | Phase 2 | psilocybin | 1 |
| Wellcome Leap Psilocybin for OUDNCT06786325 · Anna Rose Childress, Ph.D. | Recruiting | Phase 2 | psilocybin | 1 |
| Intravenous Ketamine for Treatment-Resistant DepressionNCT06668571 · Mayo Clinic | Recruiting | Phase 2 | ketamine | 1 |
| MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress DisorderNCT05837845 · Patricia Suppes | Recruiting | Phase 2 | mdma | 1 |
| A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With DepressionNCT06597695 · Juliana Zambrano, MD, MPH | Recruiting | Phase 1 / Phase 2 | ketamine | 1 |
| Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of DepressionNCT06559826 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 2 | ketamine | 1 |
| Dose Optimization of MDMA-Assisted Therapy for PTSDNCT06418178 · Bronx VA Medical Center | Recruiting | Phase 2 | mdma | 1 |
| Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive DisorderNCT06592833 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 2 | psilocybin | 1 |
| Enhancing Week-long Psychological Treatment for PTSD With KetamineNCT05737693 · Yale University | Recruiting | Phase 2 | ketamine | 2 |
| LSD to Improve Cluster Headache Impact TrialNCT05477459 · Radboud University Medical Center | Recruiting | Phase 2 | lsd | 2 |
| Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAINNCT06731335 · Unity Health Toronto | Recruiting | Phase 2 | psilocybin | 2 |
| Pharmacologic Treatment Augmentation in Chronic DepressionNCT06410599 · University Hospital Tuebingen | Recruiting | Phase 2 | ketamine | 2 |
| Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept StudyNCT06225232 · McMaster University | Recruiting | Phase 2 | psilocybin | 1 |
| MDMA for AUD/PTSD ComorbidityNCT05943665 · Carolina L Haass-Koffler | Recruiting | Phase 2 | mdma | 1 |
| Lysergic Acid Diethylamide (LSD) as Treatment for Cluster HeadacheNCT03781128 · University Hospital, Basel, Switzerland | Recruiting | Phase 2 | lsd | 1 |
| Psilocybin for Hospitalized Patients with Treatment-resistant DepressionNCT06378229 · University Hospital, Ghent | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin-Assisted Therapy for Severe Alcohol Use DisorderNCT06160232 · Brugmann University Hospital | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin-Assisted Psychotherapy for Alcohol Use DisorderNCT05995769 · University of Calgary | Recruiting | Phase 2 | psilocybin | 1 |
| The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)NCT06070649 · Yale University | Recruiting | Phase 1 | dmt | 1 |
| Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderNCT03065335 · National Institute of Mental Health (NIMH) | Recruiting | Phase 1 | ketamine | 1 |
| The RECAP2 Study: Midazolam and PsilocybinNCT06692192 · University of Wisconsin, Madison | Recruiting | Phase 1 | psilocybin | 1 |
| Safety and Tolerability Trial of Psilocybin in Healthy Older AdultsNCT07516405 · University of Colorado, Denver | Recruiting | Phase 1 | psilocybin | 6 |
| The ENHANCE Study: taVNS and PsilocybinNCT05866471 · University of Wisconsin, Madison | Recruiting | Phase 1 | psilocybin | 1 |
| Psilocybin in Chronic Low Back Pain and DepressionNCT06355414 · Johns Hopkins University | Recruiting | Phase 1 | psilocybin | 1 |
| Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.NCT07347405 · Francisco A Moreno | Recruiting | Phase 1 | psilocybin | 1 |
| Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the BrainNCT05265546 · University of California, Berkeley | Recruiting | Phase 1 | psilocybin | 1 |
| Adjunctive Effects of Psilocybin and a Formulation of BuprenorphineNCT04161066 · University of Wisconsin, Madison | Recruiting | Phase 1 | psilocybin | 1 |
| Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)NCT06160284 · Yale University | Recruiting | Phase 1 | psilocybin | 1 |
| Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant DepressionNCT06480201 · Texas A&M University | Recruiting | Phase 1 | ketamine | 2 |
| MDMA Assisted Therapy for BNNCT07542145 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 1 | mdma | 1 |
| Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionNCT03973268 · National Institute of Mental Health (NIMH) | Recruiting | Phase 1 | ketamine | 1 |
| Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in HumansNCT06671977 · Deepak C. D'Souza | Recruiting | Phase 1 | dmt | 1 |
| A Study of Psychedelics in Healthy Older Adults With Low Well-beingNCT07386730 · Jennifer Mitchell | Recruiting | Phase 1 | psilocybin | 1 |
| Group Psilocybin-Assisted Therapy for Post-Traumatic Stress DisorderNCT07506395 · University of New Mexico | Recruiting | Phase 1 | psilocybin | 1 |
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine ResponseNCT05915013 · Yale University | Recruiting | Phase 1 | ketamine | 1 |
| HNC: Human Neural Circuits Electrophysiology During CognitionNCT05962424 · Stanford University | Recruiting | Phase 1 | ketamine | 1 |
| Study of Psilocybin Assisted Psychotherapy to Address Fear of RecurrenceNCT06430541 · University of Colorado, Denver | Recruiting | Phase 1 | psilocybin | 2 |
| Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency DepartmentNCT06085937 · Lindsay Maguire, MD | Recruiting | Phase 1 | ketamine | 2 |
| MDMA-Assisted Therapy for Mental Healthcare ProvidersNCT07102576 · Rachel Yehuda | Recruiting | Phase 1 | mdma | 1 |
| Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy ParticipantsNCT07494214 · University Hospital, Basel, Switzerland | Recruiting | Phase 1 | mdma | 1 |
| Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic EffectsNCT07490353 · Medical University of Vienna | Recruiting | Phase 1 | psilocybin | 1 |
| Psilocybin-assisted Treatment for Cannabis Use DisorderNCT06660381 · Johns Hopkins University | Recruiting | Phase 1 | psilocybin | 1 |
| Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage CancerNCT06818994 · Gustavo Vazquez | Recruiting | Phase 1 | psilocybin | 1 |
| Open-Label Psilocybin Study in Transdiagnostic PopulationNCT06442423 · Yale University | Recruiting | Phase 1 | psilocybin | 1 |
| Acute Effects of Intravenous 5-MeO-DMT in Healthy ParticipantsNCT07444788 · University Hospital, Basel, Switzerland | Recruiting | Phase 1 | dmt | 1 |
| Investigation of Psychedelic Effects in Psychoactive SubstancesNCT06772753 · Johns Hopkins University | Recruiting | Phase 1 | psilocybin, mdma, dmt | 1 |
| Psychedelic Healing: Adjunct Therapy Harnessing Opened MalleabilityNCT07053917 · Johns Hopkins University | Recruiting | Phase 1 | psilocybin | 1 |
| Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy VolunteersNCT07079930 · Hadassah Medical Organization | Recruiting | Phase 1 | psilocybin | 1 |
| Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted TherapyNCT06615908 · University of Calgary | Recruiting | Phase 1 | psilocybin | 1 |
| Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based ProgramsNCT06815653 · University College, London | Recruiting | Phase 1 | psilocybin | 1 |
| Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older AdultsNCT06367738 · University of California, Berkeley | Recruiting | Phase 1 | psilocybin | 1 |
| Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)NCT06989957 · Johns Hopkins University | Recruiting | Phase 1 | psilocybin, mdma | 1 |
| Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of ConsciousnessNCT06796361 · University Hospital, Basel, Switzerland | Recruiting | Phase 1 | psilocybin | 1 |
| Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy ParticipantsNCT06899334 · University Hospital, Basel, Switzerland | Recruiting | Phase 1 | lsd, psilocybin, dmt | 1 |
| The Neurobiological Effect of 5-HT2AR ModulationNCT03289949 · Gitte Moos Knudsen | Recruiting | Phase 1 | psilocybin | 1 |
| Pharmacokinetics of GH001 Delivered Via a Proprietary Aerosol Delivery Device in Healthy SubjectsNCT06511947 · GH Research Ireland Limited | Recruiting | Phase 1 | dmt | 1 |
| Psilocybin Administration With 5-HT1a BlockadeNCT07565493 · Johns Hopkins University | Recruiting | Early Phase 1 | psilocybin | 1 |
| Effects of Psilocybin in Patients With Amyotrophic Lateral SclerosisNCT06656702 · Johns Hopkins University | Recruiting | Early Phase 1 | psilocybin | 1 |
| Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of KetamineNCT06788249 · University of Pennsylvania | Recruiting | Early Phase 1 | ketamine | 1 |
| Psilocybin as a Treatment for Chronic Pain in SmokersNCT07118332 · Yale University | Recruiting | Early Phase 1 | psilocybin | 2 |
| Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSDNCT07737054 · Tel-Aviv Sourasky Medical Center | Recruiting | Early Phase 1 | psilocybin | 1 |
| Changes in Self-awareness Induced by Psychoactive Substances: an Experimental Study With Psilocybin.NCT07732166 · Pontifícia Universidade Católica do Rio de Janeiro | Recruiting | Early Phase 1 | psilocybin | 1 |
| Mechanistic Studies of Psilocybin in Headache DisordersNCT06464367 · Yale University | Recruiting | Early Phase 1 | psilocybin | 1 |
| MDMA-assisted Therapy for FibromyalgiaNCT06066853 · Spaulding Rehabilitation Hospital | Recruiting | Early Phase 1 | mdma | 1 |
| Psilocybin for Prolonged Grief DisorderNCT06724289 · University of Virginia | Recruiting | Early Phase 1 | psilocybin | 1 |
| Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With KetamineNCT05327699 · Emory University | Recruiting | Early Phase 1 | ketamine | 1 |
| Personalized DBS Targeting for Treating DepressionNCT06784388 · Second Affiliated Hospital, Zhejiang University, School of Medicine | Recruiting | Early Phase 1 | ketamine | 1 |
| Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's DiseaseNCT04123314 · Johns Hopkins University | Recruiting | Early Phase 1 | psilocybin | 1 |
| Psilocybin-facilitated Treatment for Chronic PainNCT05068791 · University of Alabama at Birmingham | Recruiting | Early Phase 1 | psilocybin | 1 |
| Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic StudyNCT07247968 · Min Su | Recruiting | Early Phase 1 | ketamine | 2 |
| PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harmNCT06798636 · Imperial College London | Recruiting | Early Phase 1 | psilocybin | 1 |
| Psilocybin for Methamphetamine AddictionNCT06899594 · Kevin Murnane | Recruiting | Early Phase 1 | psilocybin | 1 |
| Cognitive Training as an Adjunct to Ketamine in Real-world ClinicsNCT06526078 · University of Pittsburgh | Recruiting | Not applicable | ketamine | 3 |
| The OBSERVE ProtocolNCT06725277 · Yale University | Recruiting | N/A | ketamine | 8 |
| Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant DepressionNCT07563868 · Massachusetts General Hospital | Recruiting | Not applicable | ketamine | 2 |
| Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD ClientsNCT07706478 · Senz | Recruiting | N/A | ketamine | 1 |
| Mapping Ibogaine Neural Dynamics in Opioid Use DisorderNCT07226570 · University of California, Irvine | Recruiting | N/A | ibogaine | 1 |
| ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1NCT07528014 · Salma Health, Inc. | Recruiting | N/A | ketamine | 2 |
| Belief Updating in Treatment Resistant DepressionNCT05577247 · Assistance Publique - Hôpitaux de Paris | Recruiting | N/A | ketamine | 1 |
| Retrospective Analyses of the Greenbrook Database Evaluating Mental Health TreatmentsNCT06997549 · Neuronetics | Recruiting | N/A | ketamine | 1 |
| Antidepressant Response of DMT Masked With PropofolNCT06927076 · University Hospital, Basel, Switzerland | Recruiting | Not applicable | dmt | 1 |
| Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant DepressionNCT07146503 · Riccardo Guglielmo | Recruiting | N/A | ketamine | 5 |
| Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSDNCT07461532 · Northern Jiangsu People's Hospital | Recruiting | Not applicable | lsd | 1 |
| Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSDNCT07309471 · University Hospital, Basel, Switzerland | Recruiting | Not applicable | lsd | 1 |
| ACT_for Alcohol Use Disorder and DepressionNCT06620276 · Centre hospitalier de l'Université de Montréal (CHUM) | Recruiting | Not applicable | ketamine | 1 |
| University of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · Mark Niciu | Recruiting | N/A | ketamine | 1 |
| Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant DepressionNCT07422519 · Hospital Universitari Vall d'Hebron Research Institute | Recruiting | Not applicable | ketamine | 1 |
| Ayahuasca, Esketamine and Body Image PerceptionNCT07317219 · University of Sao Paulo | Recruiting | Not applicable | dmt | 1 |
| Ayahuasca, Esketamine and Premenstrual SymptomsNCT07317232 · University of Sao Paulo | Recruiting | Not applicable | dmt | 1 |
| At-Home tDCS as Maintenance TherapyNCT07269964 · Technical University of Munich | Recruiting | Not applicable | ketamine | 2 |
| The Impact of Psilocybin on Pain in Fibromyalgia PatientsNCT06368492 · Maastricht University | Recruiting | Not applicable | psilocybin | 2 |
| Ketamine in OCD: Efficacy and Effects on Stress and CognitionNCT05577585 · Medical University of Vienna | Recruiting | Not applicable | ketamine | 1 |
| Metabolic Profiling of Esketamine Treatment in Depressive DisorderNCT07002684 · University of Zagreb | Recruiting | N/A | ketamine | 1 |
| Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy ControlsNCT06789705 · University Hospital, Basel, Switzerland | Recruiting | Not applicable | mdma | 1 |
| Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-LifeNCT06824532 · Albany Research Institute, Inc. | Recruiting | N/A | ketamine | 1 |
| Ketamine Enhances Analgesia and Mood in Chronic Pain PatientsNCT05985811 · Salem Anaesthesia Pain Clinic | Recruiting | N/A | ketamine | 1 |
| Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot StudyNCT06732089 · Unity Health Toronto | Recruiting | N/A | ketamine | 1 |
| Dexmedetomidine and Ketamine in VATS SurgeryNCT03596424 · Ciusss de L'Est de l'Île de Montréal | Recruiting | Not applicable | ketamine | 1 |
| Ketamine Treatment Plans for Chronic ConditionsNCT06038409 · RIVER Foundation | Recruiting | N/A | ketamine | 1 |
| RIVER At Home Ketamine ProtocolsNCT06070766 · RIVER Foundation | Recruiting | N/A | ketamine | 2 |
| Study of the Neural Circuits Underlying the Negative Emotional Bias of Depressive Disorders and Their Response to KetamineNCT06630065 · Centre Hospitalier St Anne | Recruiting | Not applicable | ketamine | 1 |
| IV Ketamine vs. IN Esketamine for MDD TRDNCT06488586 · Gustavo Vazquez | Recruiting | N/A | ketamine | 1 |
| Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral ReconstructionNCT07753772 · Peking University First Hospital | Not yet recruiting | Phase 4 | ketamine | 1 |
| A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant DepressionNCT07053345 · Janssen Korea, Ltd., Korea | Completed | Phase 4 | ketamine | 6 |
| Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal ThoughtsNCT07139106 · New York State Psychiatric Institute | Not yet recruiting | Phase 4 | ketamine | 1 |
| Biomarker-Guided Antidepressant SelectionNCT07680140 · Weill Medical College of Cornell University | Not yet recruiting | Phase 4 | ketamine | 1 |
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum DepressionNCT07639099 · Peking University First Hospital | Not yet recruiting | Phase 4 | ketamine | 1 |
| IM Ketamine vs Midazolam for Suicidal ER PatientsNCT04640636 · New York State Psychiatric Institute | Suspended | Phase 4 | ketamine | 1 |
| Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)NCT04814381 · University Hospital, Clermont-Ferrand | Completed | Phase 4 | ketamine | 14 |
| The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative DepressionNCT07179913 · The First Hospital of Jilin University | Active, not recruiting | Phase 4 | ketamine | 1 |
| Postpartum Perineal Pain After Obstetric Anal Sphincter InjuriesNCT03470675 · Northwestern University | Completed | Phase 4 | ketamine | 1 |
| Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for DepressionNCT05615948 · Theresa Jacob, PhD, MPH | Completed | Phase 4 | ketamine | 1 |
| Ketamine + Cognitive Training for Suicidality in the Medical SettingNCT04578938 · Rebecca Price | Active, not recruiting | Phase 4 | ketamine | 1 |
| Anhedonia, Development, and Emotions: Phenotyping and TherapeuticsNCT05487885 · Erika Forbes | Completed | Phase 4 | ketamine | 1 |
| Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt InsertionNCT06060210 · Benha University | Completed | Phase 4 | ketamine | 1 |
| Comparative Effectiveness of ECT vs. KETAMINE Over the LifespanNCT06034821 · Brigham and Women's Hospital | Enrolling by invitation | Phase 4 | ketamine | 10 |
| Propofol-Enhanced Assessment of Ketamine for Chronic Pain and DepressionNCT06317636 · Stanford University | Active, not recruiting | Phase 4 | ketamine | 1 |
| A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray TreatmentNCT04829318 · Janssen-Cilag Ltd. | Completed | Phase 4 | ketamine | 59 |
| Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant DepressionNCT05045378 · Taipei Veterans General Hospital, Taiwan | Completed | Phase 4 | ketamine | 1 |
| Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot StudyNCT05950711 · Ohio State University | Active, not recruiting | Phase 4 | ketamine | 1 |
| Ketamine for Postherpetic Neuralgia With DepressionNCT06968624 · Huazhong University of Science and Technology | Not yet recruiting | Phase 4 | ketamine | — |
| Ketamine-assisted Therapy for Advanced GI CancerNCT06077487 · Brian Anderson, MD | Terminated | Phase 4 | ketamine | 1 |
| A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant DepressionNCT04599855 · Janssen Research & Development, LLC | Completed | Phase 4 | ketamine | 54 |
| The Impact of Perioperative Ketamine Infusion on Surgical RecoveryNCT04625283 · Vanderbilt University Medical Center | Completed | Phase 4 | ketamine | 1 |
| Different Doses of Dexmedetomidine Combined With Esketamine in Women Undergoing Cesarean DeliveryNCT06613243 · Peking University First Hospital | Completed | Phase 4 | ketamine | 1 |
| Effect of Low-dose Esketamine on Maternal Depression at 3 Years After ChildbirthNCT05698394 · Peking University First Hospital | Active, not recruiting | Phase 4 | ketamine | 4 |
| Effects of Epidural Labor Analgesia With Esketamine on the Incidence of Postpartum Depression in ParturientsNCT05826327 · Women's Hospital School Of Medicine Zhejiang University | Unknown status | Phase 4 | ketamine | 1 |
| Ketamine + Cognitive Training for Suicidality in the Medical Setting: PilotNCT04154150 · Rebecca Price | Terminated | Phase 4 | ketamine | 1 |
| Effect of Esketamine on Postoperative Depression、Gut Microbiota、Bispectral Index Data of Depression Patients Undergoing Breast Cancer Operation (ESPOD-BI)NCT04303325 · China Medical University, China | Unknown status | Phase 4 | ketamine | 1 |
| A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health | Completed | Phase 4 | ketamine | 11 |
| Effectiveness of Ketamine Treatment for Three Consecutive Days in DepressionNCT05026203 · Mahidol University | Completed | Phase 4 | ketamine | 1 |
| Safety and Efficacy Evaluation of S (+) - Ketamine in ChildrenNCT04834427 · Chinese PLA General Hospital | Unknown status | Phase 4 | ketamine | 1 |
| VA Aripiprazole vs Esketamine for Treatment Resistant DepressionNCT05554627 · VA Office of Research and Development | Withdrawn | Phase 4 | ketamine | 26 |
| Ketamine Treatment Effects on Synaptic Plasticity in DepressionNCT04091971 · New York State Psychiatric Institute | Completed | Phase 4 | ketamine | 1 |
| Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac SurgeryNCT03861988 · Stanford University | Completed | Phase 4 | ketamine | 1 |
| Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the EDNCT05422001 · University of Aarhus | Terminated | Phase 4 | ketamine | 1 |
| Comparing Mescaline Sodium Enteric-coated Tablets vs Morte-mescaline in the Treatment of Adult Lupus NephritisNCT05933213 · Xiangya Hospital of Central South University | Unknown status | Phase 4 | mescaline | — |
| Clinical Study of Oral Midazolam Combined With Esketamine Administered Intranasally for Pediatric Preoperative SedationNCT05925283 · Second Affiliated Hospital of Wenzhou Medical University | Unknown status | Phase 4 | ketamine | 1 |
| Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department PatientsNCT03043430 · Brooke Army Medical Center | Terminated | Phase 4 | ketamine | 1 |
| Ketamine for Acute Pain Management After TraumaNCT04129086 · The University of Texas Health Science Center, Houston | Completed | Phase 4 | ketamine | 1 |
| The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel DiseaseNCT05506787 · Jinling Hospital, China | Completed | Phase 4 | ketamine | 1 |
| Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in DepressionNCT01881763 · Northwell Health | Completed | Phase 4 | ketamine | 1 |
| Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve GastrectomyNCT04260659 · Medical University of Warsaw | Completed | Phase 4 | ketamine | 1 |
| Ketamine for Older Adults PilotNCT04504175 · Washington University School of Medicine | Completed | Phase 4 | ketamine | 5 |
| Preoperative Ketamine and Perioperative DepressionNCT04220125 · Northwestern University | Withdrawn | Phase 4 | ketamine | — |
| An EEG Study of Intravenous Ketamine for Major Depression DisorderNCT05506462 · Ehave Inc. | Unknown status | Phase 4 | ketamine | — |
| Ketamine Versus Fentanyl for Surgical AbortionsNCT04871425 · University of Washington | Completed | Phase 4 | ketamine | 1 |
| The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.NCT03156504 · Mayo Clinic | Completed | Phase 4 | ketamine | 4 |
| Effects of Esketamine on Postpartum DepressionNCT05229913 · Qinghai University | Unknown status | Phase 4 | ketamine | — |
| Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal DepressionNCT03336541 · Peking University First Hospital | Completed | Phase 4 | ketamine | 1 |
| Tecfidera and the Gut MicrobiotaNCT02471560 · Biogen | Completed | Phase 4 | dmt | 7 |
| Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive TherapyNCT02579642 · University of Alberta | Completed | Phase 4 | ketamine | 2 |
| Intra-nasal vs. Intra-venous Ketamine AdministrationNCT02644629 · Shalvata Mental Health Center | Completed | Phase 4 | ketamine | 1 |
| Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency DepartmentNCT04266288 · MercyOne Des Moines Medical Center | Completed | Phase 4 | ketamine | 1 |
| A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)NCT03149991 · Massachusetts General Hospital | Completed | Phase 4 | ketamine | 6 |
| Ketamine Infusion for Adolescent Depression and AnxietyNCT02579928 · Yale University | Completed | Phase 4 | ketamine | 2 |
| Intranasal Sedation With Dexmedetomidine and Ketamine in Pediatric Dentistry (NASO II)NCT03290625 · Universidade Federal de Goias | Completed | Phase 4 | ketamine | 1 |
| The Effect of Ketamine on the Length of Hospital Stay of Patients Hospitalized With Suicidal Ideation.NCT02997722 · Allen Richert | Terminated | Phase 4 | ketamine | 1 |
| Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)NCT04352621 · University of Cincinnati | Unknown status | Phase 4 | ketamine | — |
| Ketamine in the Treatment of Suicidal DepressionNCT01700829 · New York State Psychiatric Institute | Completed | Phase 4 | ketamine | 1 |
| Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant DepressionNCT04234776 · University of Sao Paulo | Unknown status | Phase 4 | ketamine | 1 |
| Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or KetamineNCT03788889 · Santa Barbara Cottage Hospital | Withdrawn | Phase 4 | ketamine | — |
| Research Study for Major Depressive Disorder: Investigation of Glutamate MedicationsNCT00419003 · Baylor College of Medicine | Completed | Phase 4 | ketamine | 1 |
| Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive TherapyNCT03829124 · Chang Gung Memorial Hospital | Unknown status | Phase 4 | ketamine | — |
| Ketamine for Depression: An MRI StudyNCT02544607 · Massachusetts General Hospital | Completed | Phase 4 | ketamine | 1 |
| RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn PainNCT03305055 · Johns Hopkins University | Terminated | Phase 4 | ketamine | 1 |
| Ketamine Co-induction for Patients With Major Depressive DisorderNCT03666494 · University of Saskatchewan | Unknown status | Phase 4 | ketamine | — |
| Ketamine v. Ketorolac for Management of Generalized Tension Type HeadacheNCT03221569 · The Brooklyn Hospital Center | Unknown status | Phase 4 | ketamine | 1 |
| Ketamine vs. Placebo as Adjunctive Therapies for Severe Alcohol WithdrawalNCT02823977 · University of Colorado, Denver | Withdrawn | Phase 4 | ketamine | 1 |
| Comparing Ketamine and Propofol Anesthesia for Electroconvulsive TherapyNCT01935115 · University of Saskatchewan | Completed | Phase 4 | ketamine | 1 |
| Randomised Trial Ketiapine Olanzapine Fast Sedation Agitated Patients Emergency WardNCT03216941 · Universidad Nacional de Rosario | Completed | Phase 4 | ketamine | 1 |
| Dexamethasone and Ketamine on Change of Postoperative MoodNCT03194594 · Wonkwang University Hospital | Completed | Phase 4 | ketamine | 1 |
| N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major DepressionNCT01260649 · Massachusetts General Hospital | Terminated | Phase 4 | ketamine | 1 |
| Treatment Study of Bipolar DepressionNCT00947791 · Icahn School of Medicine at Mount Sinai | Terminated | Phase 4 | ketamine | 1 |
| Intranasal Ketamine for Late-Life Depression and Suicidal IdeationNCT02295787 · Massachusetts General Hospital | Withdrawn | Phase 4 | ketamine | — |
| Ketamine For Suicidal IdeationNCT01507181 · James Murrough | Completed | Phase 4 | ketamine | 1 |
| Effects of Ketamine and Risperidone on CognitionNCT01140620 · University of Manchester | Completed | Phase 4 | ketamine | 3 |
| Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major DepressionNCT02924090 · University of Manitoba | Unknown status | Phase 4 | ketamine | 1 |
| Clinical Trial of the Use of Ketamine in Treatment Resistant DepressionNCT02610712 · National Institute of Neurology and Neurosurgery, Mexico | Unknown status | Phase 4 | ketamine | 1 |
| The Use of Ketamine as an Anaesthetic During Electroconvulsive TherapyNCT01306760 · University of Aberdeen | Completed | Phase 4 | ketamine | 1 |
| NMDA Antagonists in Bipolar DepressionNCT01833897 · New York State Psychiatric Institute | Completed | Phase 4 | ketamine | 1 |
| D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant DepressionNCT02772211 · Sheba Medical Center | Unknown status | Phase 4 | ketamine | 1 |
| A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn PatientsNCT02336308 · University of Colorado, Denver | Withdrawn | Phase 4 | ketamine | 1 |
| Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive TherapyNCT02305394 · First Affiliated Hospital of Chongqing Medical University | Unknown status | Phase 4 | ketamine | 1 |