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Indication

Depressive Disorder

21 registered trials testing Psilocybin, Ketamine, DMT for this indication, 6 recruiting now.

Sponsors register this under 2 different names, all collected here: Depressive Disorder · Depressive Disorder,

21
Registered trials
6
Recruiting
2
In Phase 3

Substances tested

Being studied with

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Trials

All 21 trials for Depressive Disorder

TrialStatusPhaseSubstanceSites
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionNCT06511908 · National Institute of Mental Health (NIMH)RecruitingPhase 2ketamine1
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsNCT05786066 · Yale UniversityRecruitingPhase 2ketamine1
A Randomized Neuroimaging Trial of Psilocybin in DepressionNCT06072898 · Sunnybrook Health Sciences CentreRecruitingPhase 2psilocybin1
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory DepressionNCT06898606 · Federal University of Latin American IntegrationRecruitingPhase 1 / Phase 2psilocybin1
Ketamine Treatment Plans for Chronic ConditionsNCT06038409 · RIVER FoundationRecruitingN/Aketamine1
Study of the Neural Circuits Underlying the Negative Emotional Bias of Depressive Disorders and Their Response to KetamineNCT06630065 · Centre Hospitalier St AnneRecruitingNot applicableketamine1
Preoperative Ketamine and Perioperative DepressionNCT04220125 · Northwestern UniversityWithdrawnPhase 4ketamine—
Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive TherapyNCT02579642 · University of AlbertaCompletedPhase 4ketamine2
Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant DepressionNCT04234776 · University of Sao PauloUnknown statusPhase 4ketamine1
Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive TherapyNCT02267980 · Inonu UniversityUnknown statusPhase 4ketamine1
Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly PatientsNCT07153406 · Fundación Pública Andaluza para la gestión de la Investigación en SevillaNot yet recruitingPhase 3ketamine9
Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in AdolescentsNCT06957704 · Federal University of São PauloNot yet recruitingPhase 3ketamine—
Safety, Tolerability and Antidepressant Effects of DMT in Patients With DepressionNCT06094907 · Universidade Federal do Rio Grande do NorteCompletedPhase 2dmt1
Effect of SSRIs on Response to Psilocybin TherapyNCT05594667 · Cybin Therapeutics Inc.WithdrawnPhase 2psilocybin1
The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With DepressionNCT01809340 · Janssen Research & Development, LLCTerminatedPhase 2ketamine12
Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican PopulationNCT01868802 · Paul J. LamotheUnknown statusPhase 2ketamine1
Ketamine for OUD and Comorbid Depression (OUDCD)NCT05051449 · University of Maryland, BaltimoreTerminatedPhase 1ketamine1
Phenomenological Explorations of the Esketamine-Induced Transient Dissociative StateNCT06133309 · Centre Hospitalier Intercommunal de Toulon La Seyne sur MerCompletedNot applicableketamine1
Effect of Psilocybin on the Positive Valence System in Treatment-resistant DepressionNCT06650800 · Centre Hospitalier Universitaire de NīmesCompletedNot applicablepsilocybin1
Psilocybin in Alcohol Use Disorder With Comorbid DepressionNCT06235411 · Centre Hospitalier Universitaire de NīmesCompletedNot applicablepsilocybin1
Synaptic Imaging and Network Activity in Treatment Resistant DepressionNCT05870501 · King's College LondonCompletedNot applicableketamine1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.