Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSD

Inclusion Criteria: * Diagnosed with moderate to severe PTSD; * Have chronic PTSD, defined as persisting for longer than 6 months; * Have treatment-resistant PTSD, meaning unable to achieve remission despite previous therapy or medication or discontinued treatment due to inability to tolerate previous therapy or medication; * Are willing to refrain from taking any psychiatric medications during the study period; * Willing to remain overnight at the study site; * Agree to have transportation home after experimental sessions; * Are willing to be contacted via telephone for all necessary telephone contacts; * Must have a negative pregnancy test if able to bear children, and agree to use an effective form of birth control; * Are proficient in speaking and reading English; * Agree not to participate in any other interventional clinical trials during the duration of this study. Exclusion Criteria: * Are pregnant or nursing, or if of child bearing potential, are not practicing an effective means of birth control; * Weigh less than 48 kg; * Are unable to give adequate informed consent; * Upon review of past and current drugs/medication must not be on or have taken a medication that is exclusionary; * Have used "Ecstasy" (illicit drug preparations purported to contain MDMA) more than five times in the last 10 years or at least once within six months of enrollment; * Upon review of medical or psychiatric history must not have any current or past diagnosis that would be considered a risk to participation in the study.