Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic Adults

Inclusion Criteria: * Have a diagnosis of Autism Spectrum Disorder. * Have social anxiety. * Are at least 21 years old. * Have completed two years of college-level education or comparable vocational training. * Are willing to refrain from psychiatric medication for at least 5 half-lives plus a week prior to experimental session. * Agree to follow all study-related instructions and restrictions, including restrictions on food, alcohol and caffeine consumption prior to experimental sessions. * Are willing to commit to preparatory sessions, medication management, experimental sessions, follow-up sessions and to complete evaluation instruments. * Agree not to use MDMA/ecstasy outside of study sessions during the study, including the follow up period. * Are willing to be contacted on a daily basis for a week after each experimental session. * Are willing to provide a contact that is willing and able to be reached by investigators, accompany the subject during some or all of the study visits, and complete study measures. * Are willing to give blood samples. * Are proficient in speaking and reading English. Subjects communicating with text-to-speech technology will also be permitted to enroll. Exclusion Criteria: * Upon review of medical or psychiatric history must not have any current or past diagnosis that would be considered a risk to participation in the study. * Are abusing illegal drugs. * Are not able to give adequate informed consent. * Are not able to attend face-to-face visits or those who plan to move out of the area within the treatment period. * Are pregnant or nursing, or if are able to bear children and do not practice an effective means of birth control.