| A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited | Recruiting | Phase 3 | psilocybin | 68 |
| A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc. | Recruiting | Phase 3 | lsd | 30 |
| MDMA-assisted Massed Prolonged Exposure for PTSDNCT06117306 · Healing Breakthrough | Recruiting | Phase 3 | mdma | 1 |
| MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress DisorderNCT05790239 · Stephen Robert Marder | Recruiting | Phase 2 | mdma | 2 |
| Pilot Study of RR-HNK in OCDNCT06575075 · Carolyn Rodriguez | Recruiting | Phase 1 / Phase 2 | ketamine | 1 |
| Psilocybin Therapy for Depression in Parkinson's DiseaseNCT06455293 · Joshua Woolley, MD, PhD | Recruiting | Phase 2 | psilocybin | 1 |
| Mindfulness-Assisted Psychedelic TherapyNCT06233344 · University of Southern California | Recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin-Assisted Therapy for Physician Well-Being and BurnoutNCT06814522 · University of California, San Diego | Recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| Tolerability of MDMA in SchizophreniaNCT05770375 · Anya Bershad, MD, PhD | Recruiting | Phase 1 / Phase 2 | mdma | 1 |
| Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy VolunteersNCT06626139 · Robin Carhart-Harris, PhD, MA | Recruiting | Phase 2 | psilocybin | 1 |
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)NCT05940324 · Stanford University | Recruiting | Phase 2 | ketamine | 1 |
| MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)NCT05783817 · Carolyn Rodriguez | Recruiting | Phase 2 | mdma | 1 |
| Study of Psilocybin for Anorexia in Young AdultsNCT06399263 · Marissa Raymond-Flesch, MD, MPH | Recruiting | Phase 2 | psilocybin | 2 |
| RCT of Psilocybin-assisted CBT for DepressionNCT07281352 · University of California, Los Angeles | Recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| Pragmatic Trial of Psilocybin Therapy in Palliative CareNCT05403086 · Charles S. Grob, M.D. | Recruiting | Phase 2 | psilocybin, ketamine | 5 |
| MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress DisorderNCT05837845 · Patricia Suppes | Recruiting | Phase 2 | mdma | 1 |
| Safety and Tolerability Trial of Psilocybin in Healthy Older AdultsNCT07516405 · University of Colorado, Denver | Recruiting | Phase 1 | psilocybin | 6 |
| Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the BrainNCT05265546 · University of California, Berkeley | Recruiting | Phase 1 | psilocybin | 1 |
| A Study of Psychedelics in Healthy Older Adults With Low Well-beingNCT07386730 · Jennifer Mitchell | Recruiting | Phase 1 | psilocybin | 1 |
| HNC: Human Neural Circuits Electrophysiology During CognitionNCT05962424 · Stanford University | Recruiting | Phase 1 | ketamine | 1 |
| Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older AdultsNCT06367738 · University of California, Berkeley | Recruiting | Phase 1 | psilocybin | 1 |
| Cognitive Training as an Adjunct to Ketamine in Real-world ClinicsNCT06526078 · University of Pittsburgh | Recruiting | Not applicable | ketamine | 3 |
| Mapping Ibogaine Neural Dynamics in Opioid Use DisorderNCT07226570 · University of California, Irvine | Recruiting | N/A | ibogaine | 1 |
| ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1NCT07528014 · Salma Health, Inc. | Recruiting | N/A | ketamine | 2 |
| Comparative Effectiveness of ECT vs. KETAMINE Over the LifespanNCT06034821 · Brigham and Women's Hospital | Enrolling by invitation | Phase 4 | ketamine | 10 |
| Propofol-Enhanced Assessment of Ketamine for Chronic Pain and DepressionNCT06317636 · Stanford University | Active, not recruiting | Phase 4 | ketamine | 1 |
| Ketamine-assisted Therapy for Advanced GI CancerNCT06077487 · Brian Anderson, MD | Terminated | Phase 4 | ketamine | 1 |
| A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant DepressionNCT04599855 · Janssen Research & Development, LLC | Completed | Phase 4 | ketamine | 54 |
| A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health | Completed | Phase 4 | ketamine | 11 |
| VA Aripiprazole vs Esketamine for Treatment Resistant DepressionNCT05554627 · VA Office of Research and Development | Withdrawn | Phase 4 | ketamine | 26 |
| Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac SurgeryNCT03861988 · Stanford University | Completed | Phase 4 | ketamine | 1 |
| Ketamine for Older Adults PilotNCT04504175 · Washington University School of Medicine | Completed | Phase 4 | ketamine | 5 |
| A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)NCT03149991 · Massachusetts General Hospital | Completed | Phase 4 | ketamine | 6 |
| "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"NCT06564818 · Cybin IRL Limited | Active, not recruiting | Phase 3 | psilocybin | 45 |
| Efficacy, Safety, and Tolerability of COMP360 in Participants With TRDNCT05624268 · COMPASS Pathways | Completed | Phase 3 | psilocybin | 40 |
| Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRDNCT05711940 · COMPASS Pathways | Active, not recruiting | Phase 3 | psilocybin | 116 |
| A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)NCT06809595 · Definium Therapeutics US, Inc. | Active, not recruiting | Phase 3 | lsd | 36 |
| A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)NCT06941844 · Definium Therapeutics US, Inc. | Active, not recruiting | Phase 3 | lsd | 22 |
| Psilocybin for Major Depressive Disorder (MDD)NCT06308653 · Usona Institute | Active, not recruiting | Phase 3 | psilocybin | 29 |
| A Phase 3 Trial of DT120 for Generalized Anxiety Disorder (Voyage)NCT06741228 · Definium Therapeutics US, Inc. | Active, not recruiting | Phase 3 | lsd | 34 |
| Opiate Suicide Study in Patients With Major DepressionNCT04116528 · Stanford University | Completed | Phase 3 | ketamine | 1 |
| Epigenetics and MDMA-Assisted Psychotherapy for PTSDNCT06189027 · University of Southern California | Completed | Phase 3 | mdma | 1 |
| MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSDNCT05979844 · Dr. Leslie Morland | Completed | Phase 3 | mdma | 1 |
| A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)NCT03537014 · Resilient Pharmaceuticals | Completed | Phase 3 | mdma | 15 |
| A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)NCT04077437 · Resilient Pharmaceuticals | Completed | Phase 3 | mdma | 14 |
| A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSDNCT04714359 · Resilient Pharmaceuticals | Completed | Phase 3 | mdma | 15 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02417064 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 90 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02418585 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 48 |
| A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant DepressionNCT02422186 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 69 |
| A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant DepressionNCT02493868 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 155 |
| A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant DepressionNCT02782104 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 173 |
| 54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03039192 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 56 |
| 54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03097133 · Janssen Research & Development, LLC | Completed | Phase 3 | ketamine | 61 |
| A Study to Decrease Suicidal Thinking Using KetamineNCT02418702 · United States Naval Medical Center, San Diego | Withdrawn | Phase 3 | ketamine | 1 |
| Understanding How Ketamine Brings About Rapid Improvement in OCDNCT02624596 · Stanford University | Completed | Phase 2 | ketamine | 1 |
| Ketamine for Methamphetamine Use DisorderNCT06496750 · University of Texas Southwestern Medical Center | Active, not recruiting | Phase 2 | ketamine | 5 |
| Psilocybin Therapy for Methamphetamine Use Disorder and HIVNCT07756736 · Nicky Mehtani, MD, MPH | Not yet recruiting | Phase 2 | psilocybin | 1 |
| A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive DisorderNCT06340958 · Clexio Biosciences Ltd. | Completed | Phase 2 | ketamine | 23 |
| Ketamine Effects on Learning In Eating DisordersNCT06736769 · Amanda Downey, MD | Enrolling by invitation | Phase 2 | ketamine | 1 |
| Study of Psilocybin Under Anesthesia Controlled by EEGNCT07479550 · Stanford University | Not yet recruiting | Phase 2 | psilocybin | 1 |
| Group PACBT for DepressionNCT07566104 · University of California, Los Angeles | Not yet recruiting | Phase 2 | psilocybin | 1 |
| Psilocybin Therapy for Chronic Low Back PainNCT05351541 · Joshua Woolley, MD, PhD | Active, not recruiting | Phase 1 / Phase 2 | psilocybin | 1 |
| A Study of Psilocybin for Major Depressive Disorder (MDD)NCT03866174 · Usona Institute | Completed | Phase 2 | psilocybin | 11 |
| A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety SymptomsNCT05407064 · Definium Therapeutics US, Inc. | Completed | Phase 2 | lsd | 22 |
| Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery EnhancementNCT07369089 · University of California, San Diego | Not yet recruiting | Phase 2 | ketamine | 2 |
| A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO StudyNCT04103892 · Clexio Biosciences Ltd. | Completed | Phase 2 | ketamine | 46 |
| A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive DisorderNCT05733546 · COMPASS Pathways | Active, not recruiting | Phase 2 | psilocybin | 5 |
| MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSDNCT04264026 · VA Loma Linda Health Care System | Completed | Phase 2 | mdma | 1 |
| Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic AdultsNCT02008396 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening IllnessNCT02427568 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 1 |
| Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSDNCT03282123 · Resilient Pharmaceuticals | Completed | Phase 2 | mdma | 12 |
| A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant DepressionNCT01998958 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 25 |
| A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for SuicideNCT02133001 · Janssen Research & Development, LLC | Completed | Phase 2 | ketamine | 14 |
| MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in AdolescentsNCT06353282 · University of California, Los Angeles | Withdrawn | Phase 2 | mdma | 1 |
| Effects of Psilocybin in Advanced-Stage Cancer Patients With AnxietyNCT00302744 · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Completed | Phase 1 / Phase 2 | psilocybin | 1 |
| Psilocybin Therapy for Depression and Anxiety in Parkinson's DiseaseNCT04932434 · Joshua Woolley, MD, PhD | Completed | Phase 2 | psilocybin | 1 |
| Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept StudyNCT05481736 · COMPASS Pathways | Completed | Phase 2 | psilocybin | 5 |
| Psilocybin Therapy for Depression in Bipolar II DisorderNCT05065294 · University of California, San Francisco | Active, not recruiting | Phase 2 | psilocybin | 1 |
| An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)NCT04433858 · Sheppard Pratt Health System | Active, not recruiting | Phase 2 | psilocybin | 2 |
| A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRDNCT05414422 · Perception Neuroscience | Completed | Phase 2 | ketamine | 21 |
| The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant DepressionNCT04739865 · COMPASS Pathways | Completed | Phase 2 | psilocybin | 2 |
| A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of SuicideNCT04669665 · Seelos Therapeutics, Inc. | Completed | Phase 2 | ketamine | 21 |
| The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant DepressionNCT03775200 · COMPASS Pathways | Completed | Phase 2 | psilocybin | 25 |
| Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use DisorderNCT04410913 · Keith Heinzerling | Active, not recruiting | Phase 2 | psilocybin | 1 |
| Evaluation of Psilocybin in Anorexia Nervosa: Safety and EfficacyNCT04661514 · University of California, San Diego | Completed | Phase 2 | psilocybin | 1 |
| Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant DepressionNCT03756129 · Novartis Pharmaceuticals | Completed | Phase 2 | ketamine | 12 |
| ED Treatment of Suicidal Patients With Ketamine InfusionNCT03502551 · University of California, Davis | Withdrawn | Phase 2 | ketamine | 1 |
| Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)NCT01920555 · Massachusetts General Hospital | Completed | Phase 2 | ketamine | 6 |
| Neural Effects of Intravenous N,N-dimethyltryptamine (DMT)NCT07693257 · Jon Dean | Not yet recruiting | Phase 1 | dmt | 1 |
| Neural and Physiological Correlates of Psychedelic Sub-statesNCT05698511 · Robin Carhart-Harris, PhD, MA | Active, not recruiting | Phase 1 | psilocybin | 1 |
| Psilocybin-assisted CBT for DepressionNCT05227612 · University of California, Los Angeles | Completed | Phase 1 | psilocybin | 1 |
| Psilocybin-assisted Therapy for Phantom Limb PainNCT05224336 · University of California, San Diego | Completed | Phase 1 | psilocybin | 1 |
| Comparing the Effects of Psilocin and Psilocybin in Healthy AdultsNCT05317689 · University of California, San Francisco | Active, not recruiting | Phase 1 | psilocybin | 1 |
| Psilocybin With Intracranial Neural SensingNCT06919640 · Joshua Woolley, MD, PhD | Enrolling by invitation | Phase 1 | psilocybin | 1 |
| Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS SurvivorsNCT02950467 · Joshua Woolley | Completed | Phase 1 | psilocybin | 1 |
| Intravenous Ketamine Effects on Functional NeuroanatomyNCT04205890 · Neurological Associates of West Los Angeles | Withdrawn | Phase 1 | ketamine | 1 |
| Biomarkers of Fast Acting Therapies in Major DepressionNCT02165449 · University of California, Los Angeles | Completed | Phase 1 | ketamine | 1 |
| Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)NCT02911597 · Stanford University | Completed | Phase 1 | ketamine | 1 |
| Subanesthetic IV Bolus Ketamine in the Treatment of Acute DepressionNCT02378415 · United States Naval Medical Center, San Diego | Terminated | Phase 1 | ketamine | 1 |
| Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic CancerNCT05086250 · Cedars-Sinai Medical Center | Completed | Early Phase 1 | ketamine | 1 |
| Safety Profile of Psilocybin for Cocaine Use DisorderNCT06102434 · University of California, Los Angeles | Suspended | Early Phase 1 | psilocybin | 1 |
| Low-Dose Intravenous Ketamine for Adolescents With Depression and Suicidal Ideation in the Emergency DepartmentNCT05217706 · Rady Children's Hospital, San Diego | Unknown status | Early Phase 1 | ketamine | 1 |
| Ketamine for Preventing Depression in Patients Undergoing Treatment for Pancreatic or Head and Neck CancersNCT02442739 · Cedars-Sinai Medical Center | Withdrawn | Early Phase 1 | ketamine | 1 |
| Study of Oral Ketamine Versus Placebo for Treating Depression in Patients Undergoing Treatment for CancerNCT02836288 · Scott A. Irwin, MD, PhD | Completed | Early Phase 1 | ketamine | 1 |
| Trifecta Research StudyNCT07717866 · Axial Therapeutic Research | Active, not recruiting | N/A | dmt, ibogaine | 1 |
| Psychotherapy Combined With Intranasal Esketamine for the Treatment of Suicidal IdeationNCT07396220 · University of California, San Diego | Enrolling by invitation | Not applicable | ketamine | 1 |
| Stanford Regulating Circuits of the Brain Study - MDMANCT04060108 · Stanford University | Completed | N/A | mdma | 1 |
| Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast ExposureNCT04313712 · Stanford University | Active, not recruiting | N/A | ibogaine | 1 |
| Correlates of Anxiety Associated With a Life-threatening IllnessNCT02954562 · Resilient Pharmaceuticals | Completed | N/A | mdma | 1 |
| Long-Term Safety and Effectiveness of MDMA-Assisted Therapy for PTSDNCT05066282 · Resilient Pharmaceuticals | Completed | N/A | mdma | 4 |
| Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)NCT04519957 · COMPASS Pathways | Completed | N/A | psilocybin | 8 |
| Low Dose Ketamine Infusion for the Treatment of Resistant DepressionNCT04283058 · Loma Linda University | Withdrawn | N/A | ketamine | 1 |
| Pediatric Laser Acupuncture and Renal BiopsyNCT01879826 · University of California, San Francisco | Completed | Not applicable | ketamine | 2 |
| Role of Serotonin in Acute and Subacute MDMA EffectsNCT00838305 · California Pacific Medical Center Research Institute | Completed | Not applicable | mdma | 1 |
| Study of the Effects of MDMA/Ecstasy on Water Regulation, Sleep, and Cognition.NCT01053403 · California Pacific Medical Center Research Institute | Completed | Not applicable | mdma | 1 |