Texas

Psychedelic trials in Texas

71 registered trials has a study site in Texas, and 15 are recruiting now.

Trials with a site here

Recruiting

Facilities

Open now

Recruiting in this state

Trial	Status	Phase	Substance	Sites
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma PatientsNCT06903819 · Texas Tech University Health Sciences Center	Recruiting	Phase 4	ketamine	2
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSDNCT06414356 · Margaux M. Salas, PhD	Recruiting	Phase 4	ketamine	1
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited	Recruiting	Phase 3	psilocybin	68
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc.	Recruiting	Phase 3	lsd	30
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence StudyNCT06713616 · Yale University	Recruiting	Phase 3	ketamine	8
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive DisorderNCT07227454 · Janssen Research & Development, LLC	Recruiting	Phase 3	ketamine	35
Ketamine & Crisis Response Plan for Suicidal Ideation in the EDNCT05696691 · The University of Texas Health Science Center at San Antonio	Recruiting	Phase 2 / Phase 3	ketamine	1
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance TherapyNCT06200155 · M.D. Anderson Cancer Center	Recruiting	Phase 2	psilocybin	1
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and SuicidalityNCT06706232 · The University of Texas Health Science Center, Houston	Recruiting	Phase 2	psilocybin	1
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer SurvivorsNCT06801041 · M.D. Anderson Cancer Center	Recruiting	Phase 2	psilocybin	1
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing TraumaNCT06888128 · Baylor College of Medicine	Recruiting	Phase 2	psilocybin	1
Psilocybin rTMS for Treatment Resistant DepressionNCT06132178 · University of Texas at Austin	Recruiting	Phase 2	psilocybin	1
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant DepressionNCT06480201 · Texas A&M University	Recruiting	Phase 1	ketamine	2
Cognitive Training as an Adjunct to Ketamine in Real-world ClinicsNCT06526078 · University of Pittsburgh	Recruiting	Not applicable	ketamine	3
The OBSERVE ProtocolNCT06725277 · Yale University	Recruiting	N/A	ketamine	8

Facilities

Where the research happens in Texas

Facility	City	Trials
The University of Texas Health Science Center at Houston	Houston	6
Austin Clinical Trial Partners	Austin	5
Baylor College of Medicine	Houston	4
Brooke Army Medical Center	San Antonio	3
Brain Health Consultants and TMS Center	Houston	3
University of Texas Southwestern Medical Center	Dallas	3
UT Southwestern Medical Center	Dallas	3
Seelos Investigational Site	DeSoto	3
North Texas Clinical Trials	Fort Worth	2
Houston Center for Advanced Psychiatric Treatment	Bellaire	2
University Hospital	San Antonio	2
MD Anderson Cancer Center	Houston	2
Relaro Medical Trials	Dallas	2
Pillar Clinical Research, LLC	Richardson	2
Michael E. DeBakey VA Medical Center, Houston, TX	Houston	2
BioBehavioral Research of Austin	Austin	2
UT Center of Excellence on Mood Disorders, University of Texas Health Science Center	Houston	2
Klarisana	San Antonio	2
Texas Tech University Health Sciences Center Lubbock	Lubbock	1
University Medical Center	Lubbock	1
Flourish Research San Antonio	San Antonio	1
John S Dunn Behavioral Sciences Center at UTHealth Houston	Houston	1
The University of Texas M. D. Anderson Cancer Center	Houston	1
Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600	Austin	1
Wells Medicine	Houston	1
Texas A&M (Houston Methodist Hospital Location)	Houston	1
UTHealth Houston	Houston	1
BioBehavioral Research of Austin PC	Austin	1
Family Psychiatry of The Woodlands	The Woodlands	1
Grayline Research Center	Wichita Falls	1
Houston Centre	Houston	1
San Antonio Military Medical Center	Fort Sam Houston	1
InSite Clinical Research, LLC	DeSota	1
Zillan Clinical Research	Houston	1
UT Health Science Center at Houston (UTHSC-H)	Houston	1
The University of Texas at Austin - Dell Medical School	Austin	1
Houston Clinical Trials, LLC	Bellaire	1
Center for Depression Research and Clinical Care	Dallas	1
HCA Healthcare Research Institute - Medical City Green Oaks Hospital	Plano	1
AIM Trials, LLC	Plano	1

Stay told

When a trial opens in Texas

All trials

Every trial with a Texas site

Trial	Status	Phase	Substance	Sites
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma PatientsNCT06903819 · Texas Tech University Health Sciences Center	Recruiting	Phase 4	ketamine	2
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSDNCT06414356 · Margaux M. Salas, PhD	Recruiting	Phase 4	ketamine	1
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited	Recruiting	Phase 3	psilocybin	68
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc.	Recruiting	Phase 3	lsd	30
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence StudyNCT06713616 · Yale University	Recruiting	Phase 3	ketamine	8
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive DisorderNCT07227454 · Janssen Research & Development, LLC	Recruiting	Phase 3	ketamine	35
Ketamine & Crisis Response Plan for Suicidal Ideation in the EDNCT05696691 · The University of Texas Health Science Center at San Antonio	Recruiting	Phase 2 / Phase 3	ketamine	1
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance TherapyNCT06200155 · M.D. Anderson Cancer Center	Recruiting	Phase 2	psilocybin	1
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and SuicidalityNCT06706232 · The University of Texas Health Science Center, Houston	Recruiting	Phase 2	psilocybin	1
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer SurvivorsNCT06801041 · M.D. Anderson Cancer Center	Recruiting	Phase 2	psilocybin	1
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing TraumaNCT06888128 · Baylor College of Medicine	Recruiting	Phase 2	psilocybin	1
Psilocybin rTMS for Treatment Resistant DepressionNCT06132178 · University of Texas at Austin	Recruiting	Phase 2	psilocybin	1
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant DepressionNCT06480201 · Texas A&M University	Recruiting	Phase 1	ketamine	2
Cognitive Training as an Adjunct to Ketamine in Real-world ClinicsNCT06526078 · University of Pittsburgh	Recruiting	Not applicable	ketamine	3
The OBSERVE ProtocolNCT06725277 · Yale University	Recruiting	N/A	ketamine	8
Comparative Effectiveness of ECT vs. KETAMINE Over the LifespanNCT06034821 · Brigham and Women's Hospital	Enrolling by invitation	Phase 4	ketamine	10
A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant DepressionNCT04599855 · Janssen Research & Development, LLC	Completed	Phase 4	ketamine	54
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health	Completed	Phase 4	ketamine	11
VA Aripiprazole vs Esketamine for Treatment Resistant DepressionNCT05554627 · VA Office of Research and Development	Withdrawn	Phase 4	ketamine	26
Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department PatientsNCT03043430 · Brooke Army Medical Center	Terminated	Phase 4	ketamine	1
Ketamine for Acute Pain Management After TraumaNCT04129086 · The University of Texas Health Science Center, Houston	Completed	Phase 4	ketamine	1
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"NCT06564818 · Cybin IRL Limited	Active, not recruiting	Phase 3	psilocybin	45
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRDNCT05624268 · COMPASS Pathways	Completed	Phase 3	psilocybin	40
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRDNCT05711940 · COMPASS Pathways	Active, not recruiting	Phase 3	psilocybin	116
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)NCT06809595 · Definium Therapeutics US, Inc.	Active, not recruiting	Phase 3	lsd	36
A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)NCT06941844 · Definium Therapeutics US, Inc.	Active, not recruiting	Phase 3	lsd	22
Psilocybin for Major Depressive Disorder (MDD)NCT06308653 · Usona Institute	Active, not recruiting	Phase 3	psilocybin	29
A Phase 3 Trial of DT120 for Generalized Anxiety Disorder (Voyage)NCT06741228 · Definium Therapeutics US, Inc.	Active, not recruiting	Phase 3	lsd	34
Ketamine Versus Midazolam for Recurrence of Suicidality in AdolescentsNCT04592809 · University of Texas Southwestern Medical Center	Completed	Phase 3	ketamine	1
A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02417064 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	90
A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02418585 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	48
A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant DepressionNCT02422186 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	69
A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant DepressionNCT02493868 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	155
A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant DepressionNCT02497287 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	109
A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant DepressionNCT02782104 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	173
54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03039192 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	56
NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar DepressionNCT03396601 · NeuroRx, Inc.	Unknown status	Phase 3	ketamine	2
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)NCT03113968 · Bo Hu	Completed	Phase 2 / Phase 3	ketamine	5
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol AbuseNCT03539887 · The University of Texas Health Science Center, Houston	Completed	Phase 3	ketamine	1
Ketamine for Treatment Resistant Late-Life DepressionNCT02556606 · VA Office of Research and Development	Completed	Phase 3	ketamine	1
NeuroGuard: Psilocybin Trial for Preventing Chemo-induced NeuropathyNCT07227909 · M.D. Anderson Cancer Center	Not yet recruiting	Phase 2	psilocybin	1
Ketamine for Methamphetamine Use DisorderNCT06496750 · University of Texas Southwestern Medical Center	Active, not recruiting	Phase 2	ketamine	5
A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive DisorderNCT06340958 · Clexio Biosciences Ltd.	Completed	Phase 2	ketamine	23
The Acute Effects of Psilocybin on Cognition, Memory, and Brain FunctionNCT07079852 · Manoj Doss	Not yet recruiting	Phase 1 / Phase 2	psilocybin	1
Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002NCT06816433 · Global Coalition for Adaptive Research	Suspended	Phase 2	ketamine	9
A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety SymptomsNCT05407064 · Definium Therapeutics US, Inc.	Completed	Phase 2	lsd	22
Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)NCT06795659 · The University of Texas Health Science Center at San Antonio	Completed	Phase 1 / Phase 2	ketamine	1
A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO StudyNCT04103892 · Clexio Biosciences Ltd.	Completed	Phase 2	ketamine	46
A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive DisorderNCT05733546 · COMPASS Pathways	Active, not recruiting	Phase 2	psilocybin	5
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic TargetsNCT05046184 · University of Texas Southwestern Medical Center	Completed	Phase 2	ketamine	1
A Study of Ketamine in Patients With Treatment-resistant DepressionNCT01627782 · Janssen Research & Development, LLC	Completed	Phase 2	ketamine	13
A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for SuicideNCT02133001 · Janssen Research & Development, LLC	Completed	Phase 2	ketamine	14
Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for SuicideNCT03185819 · Janssen Research & Development, LLC	Completed	Phase 2	ketamine	51
Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept StudyNCT05481736 · COMPASS Pathways	Completed	Phase 2	psilocybin	5
A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRDNCT05414422 · Perception Neuroscience	Completed	Phase 2	ketamine	21
A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of SuicideNCT04669665 · Seelos Therapeutics, Inc.	Completed	Phase 2	ketamine	21
The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant DepressionNCT03775200 · COMPASS Pathways	Completed	Phase 2	psilocybin	25
CAP-Ketamine for Antidepressant Resistant PTSDNCT02655692 · VA Office of Research and Development	Completed	Phase 2	ketamine	3
Low Dose Intravenous Ketamine in Treatment Resistant Depression PatientsNCT02935595 · The University of Texas Health Science Center, Houston	Completed	Phase 2	ketamine	1
Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum DepressionNCT04011592 · The University of Texas Health Science Center, Houston	Terminated	Phase 2	ketamine	1
Sequential Therapy for the Treatment of Severe Bipolar Depression.NCT02974010 · NeuroRx, Inc.	Completed	Phase 2	ketamine	4
A Single Ketamine Infusion Combined With Music for Suicidal IdeationNCT04658420 · The University of Texas Health Science Center at Tyler	Unknown status	Phase 2	ketamine	1
The UTHealth Ketamine ProjectNCT02882711 · The University of Texas Health Science Center, Houston	Terminated	Phase 2	ketamine	1
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)NCT01920555 · Massachusetts General Hospital	Completed	Phase 2	ketamine	6
Optimization of IV Ketamine for Treatment Resistant DepressionNCT00768430 · Baylor College of Medicine	Completed	Phase 2	ketamine	2
Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG)NCT05095792 · Entheon Biomedical Corp.	Terminated	N/A	ketamine	1
Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)NCT04519957 · COMPASS Pathways	Completed	N/A	psilocybin	8
Ketamine Infusion Therapy for the Treatment of PTSD in ParamedicsNCT03947099 · Klarisana Physician Services PLLC	Completed	N/A	ketamine	1
Ketamine Infusion Therapy for PTSD in Combat VeteransNCT03088384 · Klarisana Physician Services PLLC	Completed	N/A	ketamine	1
Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive SymptomsNCT02422303 · The University of Texas Health Science Center at San Antonio	Terminated	Not applicable	ketamine	1
Ketamine for Acute Suicidal Ideation in the Emergency Department: Randomized Controlled TrialNCT01892995 · Brooke Army Medical Center	Unknown status	Not applicable	ketamine	1

Site locations from ClinicalTrials.gov API v2, data build 2026-08-25.

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