Illinois

Psychedelic trials in Illinois

47 registered trials has a study site in Illinois, and 7 are recruiting now.

Trials with a site here

Recruiting

Facilities

Open now

Recruiting in this state

Trial	Status	Phase	Substance	Sites
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderNCT07570654 · COMPASS Pathways	Recruiting	Phase 2 / Phase 3	psilocybin	8
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited	Recruiting	Phase 3	psilocybin	79
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc.	Recruiting	Phase 3	lsd	30
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive DisorderNCT07227454 · Janssen Research & Development, LLC	Recruiting	Phase 3	ketamine	44
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant DepressionNCT07716098 · Janssen Research & Development, LLC	Recruiting	Phase 3	ketamine	22
Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSDNCT06608277 · Northwestern University	Recruiting	Phase 2	ketamine	3
Cognitive Training as an Adjunct to Ketamine in Real-world ClinicsNCT06526078 · University of Pittsburgh	Recruiting	Not applicable	ketamine	3

Facilities

Where the research happens in Illinois

Facility	City	Trials
University of Chicago	Chicago	12
Rush University Medical Center	Chicago	5
Uptown Research Institute	Chicago	4
Great Lakes Clinical Trials	Chicago	3
Rush University	Chicago	2
Endeavor Health Evanston Hospital	Evanston	2
Psychiatric Medicine Associates LLC	Skokie	2
Uptown Research Institute, LLC	Chicago	2
Neuroscience Research Institute	Winfield	2
Matthew Bona	Chicago	2
IL	Chicago	1
Anesthesiology Pain Medicine Center	Chicago	1
University of Illinois at Chicago	Chicago	1
Northwestern University	Chicago	1
Chicago Research Center	Chicago	1
Joliet Center for Clinical Research	Joliet	1
Pillar Clinical Research, LLC	Lincolnwood	1
Chicago Centre	Chicago	1
Edward Hines Jr. VA Hospital, Hines, IL	Hines	1
Great Lakes Clinical Trials, DBA Flourish Research	Chicago	1
Psychiatric Medicine Associates, LLC	Skokie	1
Uptown Research Institute (URI), LLC	Chicago	1
Psychiatric Medicine Associates	Skokie	1
Alexian Behavioral Health Hospital	Hoffman Estates	1
Memorial Medical Center	Springfield	1
Clinical Site 127	Chicago	1
Clinical Site 120	Elgin	1
Uptown Research	Chicago	1
Seelos Investigational Site	Springfield	1
Novartis Investigative Site	Skokie	1
Stella Center	Westmont	1
The Neuroscience Center	Deerfield	1

Stay told

When a trial opens in Illinois

All trials

Every trial with a Illinois site

Trial	Status	Phase	Substance	Sites
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderNCT07570654 · COMPASS Pathways	Recruiting	Phase 2 / Phase 3	psilocybin	8
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited	Recruiting	Phase 3	psilocybin	79
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc.	Recruiting	Phase 3	lsd	30
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive DisorderNCT07227454 · Janssen Research & Development, LLC	Recruiting	Phase 3	ketamine	44
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant DepressionNCT07716098 · Janssen Research & Development, LLC	Recruiting	Phase 3	ketamine	22
Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSDNCT06608277 · Northwestern University	Recruiting	Phase 2	ketamine	3
Cognitive Training as an Adjunct to Ketamine in Real-world ClinicsNCT06526078 · University of Pittsburgh	Recruiting	Not applicable	ketamine	3
Postpartum Perineal Pain After Obstetric Anal Sphincter InjuriesNCT03470675 · Northwestern University	Completed	Phase 4	ketamine	1
A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant DepressionNCT04599855 · Janssen Research & Development, LLC	Completed	Phase 4	ketamine	54
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental HealthNCT05604794 · Field Trip Health	Completed	Phase 4	ketamine	11
VA Aripiprazole vs Esketamine for Treatment Resistant DepressionNCT05554627 · VA Office of Research and Development	Withdrawn	Phase 4	ketamine	26
A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)NCT03149991 · Massachusetts General Hospital	Completed	Phase 4	ketamine	6
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"NCT06564818 · Cybin IRL Limited	Active, not recruiting	Phase 3	psilocybin	45
A Phase 3 Trial of DT120 for Generalized Anxiety Disorder (Voyage)NCT06741228 · Definium Therapeutics US, Inc.	Active, not recruiting	Phase 3	lsd	34
A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)NCT06941844 · Definium Therapeutics US, Inc.	Active, not recruiting	Phase 3	lsd	22
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRDNCT05624268 · COMPASS Pathways	Completed	Phase 3	psilocybin	40
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRDNCT05711940 · COMPASS Pathways	Active, not recruiting	Phase 3	psilocybin	116
Psilocybin for Major Depressive Disorder (MDD)NCT06308653 · Usona Institute	Active, not recruiting	Phase 3	psilocybin	29
A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02417064 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	90
A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionNCT02418585 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	48
A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant DepressionNCT02493868 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	155
A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant DepressionNCT02782104 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	173
54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03039192 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	56
54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideNCT03097133 · Janssen Research & Development, LLC	Completed	Phase 3	ketamine	61
A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants With Generalized Anxiety Disorder (GAD)NCT06051721 · Cybin IRL Limited	Completed	Phase 2	dmt	6
A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive DisorderNCT06340958 · Clexio Biosciences Ltd.	Completed	Phase 2	ketamine	23
A Study of Psilocybin for Major Depressive Disorder (MDD)NCT03866174 · Usona Institute	Completed	Phase 2	psilocybin	11
A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety SymptomsNCT05407064 · Definium Therapeutics US, Inc.	Completed	Phase 2	lsd	22
Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality DisorderNCT05399498 · University of Chicago	Completed	Phase 2	psilocybin	1
A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant DepressionNCT01998958 · Janssen Research & Development, LLC	Completed	Phase 2	ketamine	25
Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for SuicideNCT03185819 · Janssen Research & Development, LLC	Completed	Phase 2	ketamine	51
A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of SuicideNCT04669665 · Seelos Therapeutics, Inc.	Completed	Phase 2	ketamine	21
Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant DepressionNCT03756129 · Novartis Pharmaceuticals	Completed	Phase 2	ketamine	12
A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant DepressionNCT05268497 · Janssen Research & Development, LLC	Withdrawn	Phase 1	ketamine	5
Mood Effects of Serotonin AgonistsNCT03790358 · University of Chicago	Completed	Phase 1	lsd	2
Effect of Stimulant Drugs on Social PerceptionNCT03790618 · University of Chicago	Completed	Phase 1	mdma	1
Mood Effects of Serotonin Agonists ExtendedNCT03934710 · University of Chicago	Completed	Phase 1	lsd	1
Mood Effects of Serotonin Agonists: DepressionNCT07017478 · University of Chicago	Completed	Early Phase 1	lsd	1
Drug Effects on Mood and Behavior - ExpectancyNCT07061886 · University of Chicago	Completed	Early Phase 1	lsd	1
Effects of Drugs on Responses to Brain and Emotional ProcessesNCT04053036 · University of Chicago	Completed	Early Phase 1	mdma	1
Prosocial Effects of MDMANCT05948683 · University of Chicago	Completed	Early Phase 1	mdma	1
Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social FunctionNCT05379959 · University of Chicago	Completed	Early Phase 1	mdma	1
Drug Effects on Interpersonal InteractionNCT05123716 · University of Chicago	Completed	Early Phase 1	mdma	1
Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal DistressNCT07810023 · Endeavor Health	Enrolling by invitation	Not applicable	ketamine	1
Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces CohortNCT05855876 · Stella Center	Unknown status	N/A	ketamine	1
Effects of MDMA on Social and Emotional ProcessingNCT01849419 · University of Chicago	Completed	Not applicable	mdma	1
Neuromodulation to Facilitate the Effect of KetamineNCT01816958 · The Neuroscience Center, LLC	Completed	N/A	ketamine	1

Site locations from ClinicalTrials.gov API v2, data build 2026-10-06.

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