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CompletedEarly Phase 1

Prosocial Effects of MDMA

NCT05948683 · PEM · University of Chicago

Closed to entry
Status
Not accepting participants
Early Phase 1
Phase
33
Target enrolment
1
Study sites
1 US states

What it is testing

Summary

In this study, the aim is to test the hypothesis that MDMA produces greater prosocial effects when administered in the presence of a familiar, compared to an unfamiliar, person

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Natural Language Processing using large language model

    Measured over during 15 minute test conversation, occurring 1.5 hours after drug administration

  • Facial expression analysis using HUMEAI software

    Measured over during 15 minute test conversation, occurring 1.5 hours after drug administration

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 35 Years
Ages
All
Sex
Accepted
Healthy volunteers
Inclusion Criteria: * used MDMA or psychedelic between 1-40 * high school diploma or equivalent * BMI between 19 and 30 * verbal fluency in English Exclusion Criteria: * History of adverse effects with MDMA * High blood pressure * Any medical condition requiring regular medication * Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis * Women who are pregnant or trying to become pregnant.

Where

1 study site

FacilityCityRegionCountry
University of ChicagoChicagoIllinoisUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT05948683 on ClinicalTrials.gov →

Last updated in the registry 2024-08-19. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits