| Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderNCT07570654 · COMPASS Pathways | Recruiting | Phase 2 / Phase 3 | 1 |
| A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL Limited | Recruiting | Phase 3 | 68 |
| Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionNCT07226232 · VA Office of Research and Development | Recruiting | Phase 3 | 5 |
| The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive DisorderNCT06247839 · Sharmin Ghaznavi | Recruiting | Phase 3 | 1 |
| Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive DisorderNCT07703722 · Khyber Medical University Peshawar | Recruiting | Phase 3 | 3 |
| Psilocybin Microdose for Psychological and Existential Distress in Palliative Care (PSYCHED-PAL-RCT)NCT07063862 · Bruyère Health Research Institute. | Recruiting | Phase 3 | 7 |
| Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive SymptomsNCT07638553 · Centre Hospitalier Universitaire de Nīmes | Recruiting | Phase 3 | 8 |
| Psilocybin Therapy in Advanced CancerNCT05398484 · NYU Langone Health | Recruiting | Phase 2 / Phase 3 | 2 |
| Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant DepressionNCT07211438 · Centre for Addiction and Mental Health | Recruiting | Phase 2 | 2 |
| Safety, Therapeutic Potential, and Mechanisms of Two Psilocybin Doses, Administered With Psychological Support in Young Adults With Anorexia NervosaNCT07169747 · Region Skane | Recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Therapy for Intergenerational TraumaNCT06899165 · Rachel Yehuda | Recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance TherapyNCT06200155 · M.D. Anderson Cancer Center | Recruiting | Phase 2 | 1 |
| Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUDNCT06349083 · NYU Langone Health | Recruiting | Phase 2 | 1 |
| Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and SuicidalityNCT06706232 · The University of Texas Health Science Center, Houston | Recruiting | Phase 2 | 1 |
| TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer SurvivorsNCT06801041 · M.D. Anderson Cancer Center | Recruiting | Phase 2 | 1 |
| Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety DisorderNCT06969170 · Claudio N Soares | Recruiting | Phase 2 | 1 |
| Investigation to Understand and Optimize PsilocybinNCT06512194 · Charles Raison | Recruiting | Phase 2 | 1 |
| Psilocybin to Treat Depression in Spinal Cord InjuryNCT07251491 · James J. Peters Veterans Affairs Medical Center | Recruiting | Phase 1 / Phase 2 | 1 |
| Psilocybin Therapy for Depression in Parkinson's DiseaseNCT06455293 · Joshua Woolley, MD, PhD | Recruiting | Phase 2 | 1 |
| Mindfulness-Assisted Psychedelic TherapyNCT06233344 · University of Southern California | Recruiting | Phase 2 | 1 |
| Psilocybin in Cancer Pain StudyNCT06001749 · Yvan Beaussant, MD, MSci | Recruiting | Phase 2 | 1 |
| Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)NCT06512220 · Centre for Addiction and Mental Health | Recruiting | Phase 2 | 1 |
| Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)NCT06518720 · Centre for Addiction and Mental Health | Recruiting | Phase 2 | 1 |
| Effects of Psilocybin on Electrophysiology and the Dynamic Content of ThoughtNCT05301608 · Johns Hopkins University | Recruiting | Phase 1 / Phase 2 | 1 |
| A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and AnxietyNCT06820723 · Ohio State University | Recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Therapy for Physician Well-Being and BurnoutNCT06814522 · University of California, San Diego | Recruiting | Phase 1 / Phase 2 | 1 |
| Psilocybin Efficacy With or Without Pimavanserin PretreatmentNCT07610135 · Johns Hopkins University | Recruiting | Phase 1 / Phase 2 | 1 |
| The Efficacy of Psilocybin Therapy for Depression in Parkinson's DiseaseNCT07610369 · Yale University | Recruiting | Phase 2 | 1 |
| Outpatient Buprenorphine Induction With Psilocybin for Opioid Use DisorderNCT06067737 · Johns Hopkins University | Recruiting | Phase 2 | 1 |
| Psilocybin on Brain Mechanisms of Motivation in OUDNCT06810310 · University of Pennsylvania | Recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Therapy for Sexual Assault-Related PTSDNCT06902974 · Sunstone Medical | Recruiting | Phase 2 | 1 |
| 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use DisorderNCT05452772 · Johns Hopkins University | Recruiting | Phase 2 | 3 |
| Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSDNCT06386003 · Unity Health Toronto | Recruiting | Phase 2 | 1 |
| Mindfulness-based Psilocybin Therapy for PTSDNCT07104916 · Anthony P King | Recruiting | Phase 2 | 1 |
| Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Caregivers of Patients With Advanced CancerNCT07048743 · University Health Network, Toronto | Recruiting | Phase 2 | 1 |
| Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy VolunteersNCT06626139 · Robin Carhart-Harris, PhD, MA | Recruiting | Phase 2 | 1 |
| Subjective Experience Following PsilocybinNCT06768944 · University of Calgary | Recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung CancerNCT07216404 · Alan Davis | Recruiting | Phase 2 | 1 |
| Psilocybin Therapy for Psychological Distress in Palliative PatientsNCT06782724 · University Medical Center Groningen | Recruiting | Phase 2 | 4 |
| Cancer Related Major Depression Treated With a Single Dose of PsilocybinNCT06319378 · Section for Affective Disorders; Northern Stockholm Psychiatry | Recruiting | Phase 2 | 4 |
| A Randomized Neuroimaging Trial of Psilocybin in DepressionNCT06072898 · Sunnybrook Health Sciences Centre | Recruiting | Phase 2 | 1 |
| Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory DepressionNCT06898606 · Federal University of Latin American Integration | Recruiting | Phase 1 / Phase 2 | 1 |
| Study of Psilocybin for Anorexia in Young AdultsNCT06399263 · Marissa Raymond-Flesch, MD, MPH | Recruiting | Phase 2 | 2 |
| Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment DisorderNCT07072728 · Psyence Australia Pty Ltd | Recruiting | Phase 2 | 3 |
| RCT of Psilocybin-assisted CBT for DepressionNCT07281352 · University of California, Los Angeles | Recruiting | Phase 1 / Phase 2 | 1 |
| Psilocybin for Opioid Use Disorder (OUD)NCT06796062 · NYU Langone Health | Recruiting | Phase 2 | 5 |
| State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing TraumaNCT06888128 · Baylor College of Medicine | Recruiting | Phase 2 | 1 |
| Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid MedicationNCT05585229 · University of British Columbia | Recruiting | Phase 2 | 1 |
| Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator TrialNCT06405607 · University of Iowa | Recruiting | Phase 2 | 1 |
| Psilocybin rTMS for Treatment Resistant DepressionNCT06132178 · University of Texas at Austin | Recruiting | Phase 2 | 1 |
| Pragmatic Trial of Psilocybin Therapy in Palliative CareNCT05403086 · Charles S. Grob, M.D. | Recruiting | Phase 2 | 5 |
| Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCDNCT04882839 · Beersheva Mental Health Center | Recruiting | Phase 2 | 1 |
| Psilocybin Microdosing With Psychotherapy for Treatment-Resistant DepressionNCT07183748 · Beersheva Mental Health Center | Recruiting | Phase 2 | 1 |
| Wellcome Leap Psilocybin for OUDNCT06786325 · Anna Rose Childress, Ph.D. | Recruiting | Phase 2 | 1 |
| Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive DisorderNCT06592833 · Icahn School of Medicine at Mount Sinai | Recruiting | Phase 2 | 1 |
| Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAINNCT06731335 · Unity Health Toronto | Recruiting | Phase 2 | 2 |
| Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept StudyNCT06225232 · McMaster University | Recruiting | Phase 2 | 1 |
| Psilocybin for Hospitalized Patients with Treatment-resistant DepressionNCT06378229 · University Hospital, Ghent | Recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Therapy for Severe Alcohol Use DisorderNCT06160232 · Brugmann University Hospital | Recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Psychotherapy for Alcohol Use DisorderNCT05995769 · University of Calgary | Recruiting | Phase 2 | 1 |
| The RECAP2 Study: Midazolam and PsilocybinNCT06692192 · University of Wisconsin, Madison | Recruiting | Phase 1 | 1 |
| Safety and Tolerability Trial of Psilocybin in Healthy Older AdultsNCT07516405 · University of Colorado, Denver | Recruiting | Phase 1 | 6 |
| The ENHANCE Study: taVNS and PsilocybinNCT05866471 · University of Wisconsin, Madison | Recruiting | Phase 1 | 1 |
| Psilocybin in Chronic Low Back Pain and DepressionNCT06355414 · Johns Hopkins University | Recruiting | Phase 1 | 1 |
| Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.NCT07347405 · Francisco A Moreno | Recruiting | Phase 1 | 1 |
| Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the BrainNCT05265546 · University of California, Berkeley | Recruiting | Phase 1 | 1 |
| Adjunctive Effects of Psilocybin and a Formulation of BuprenorphineNCT04161066 · University of Wisconsin, Madison | Recruiting | Phase 1 | 1 |
| Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)NCT06160284 · Yale University | Recruiting | Phase 1 | 1 |
| A Study of Psychedelics in Healthy Older Adults With Low Well-beingNCT07386730 · Jennifer Mitchell | Recruiting | Phase 1 | 1 |
| Group Psilocybin-Assisted Therapy for Post-Traumatic Stress DisorderNCT07506395 · University of New Mexico | Recruiting | Phase 1 | 1 |
| Study of Psilocybin Assisted Psychotherapy to Address Fear of RecurrenceNCT06430541 · University of Colorado, Denver | Recruiting | Phase 1 | 2 |
| Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic EffectsNCT07490353 · Medical University of Vienna | Recruiting | Phase 1 | 1 |
| Psilocybin-assisted Treatment for Cannabis Use DisorderNCT06660381 · Johns Hopkins University | Recruiting | Phase 1 | 1 |
| Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage CancerNCT06818994 · Gustavo Vazquez | Recruiting | Phase 1 | 1 |
| Open-Label Psilocybin Study in Transdiagnostic PopulationNCT06442423 · Yale University | Recruiting | Phase 1 | 1 |
| Investigation of Psychedelic Effects in Psychoactive SubstancesNCT06772753 · Johns Hopkins University | Recruiting | Phase 1 | 1 |
| Psychedelic Healing: Adjunct Therapy Harnessing Opened MalleabilityNCT07053917 · Johns Hopkins University | Recruiting | Phase 1 | 1 |
| Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy VolunteersNCT07079930 · Hadassah Medical Organization | Recruiting | Phase 1 | 1 |
| Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted TherapyNCT06615908 · University of Calgary | Recruiting | Phase 1 | 1 |
| Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based ProgramsNCT06815653 · University College, London | Recruiting | Phase 1 | 1 |
| Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older AdultsNCT06367738 · University of California, Berkeley | Recruiting | Phase 1 | 1 |
| Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)NCT06989957 · Johns Hopkins University | Recruiting | Phase 1 | 1 |
| Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of ConsciousnessNCT06796361 · University Hospital, Basel, Switzerland | Recruiting | Phase 1 | 1 |
| Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy ParticipantsNCT06899334 · University Hospital, Basel, Switzerland | Recruiting | Phase 1 | 1 |
| The Neurobiological Effect of 5-HT2AR ModulationNCT03289949 · Gitte Moos Knudsen | Recruiting | Phase 1 | 1 |
| Psilocybin Administration With 5-HT1a BlockadeNCT07565493 · Johns Hopkins University | Recruiting | Early Phase 1 | 1 |
| Effects of Psilocybin in Patients With Amyotrophic Lateral SclerosisNCT06656702 · Johns Hopkins University | Recruiting | Early Phase 1 | 1 |
| Psilocybin as a Treatment for Chronic Pain in SmokersNCT07118332 · Yale University | Recruiting | Early Phase 1 | 2 |
| Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSDNCT07737054 · Tel-Aviv Sourasky Medical Center | Recruiting | Early Phase 1 | 1 |
| Changes in Self-awareness Induced by Psychoactive Substances: an Experimental Study With Psilocybin.NCT07732166 · Pontifícia Universidade Católica do Rio de Janeiro | Recruiting | Early Phase 1 | 1 |
| Mechanistic Studies of Psilocybin in Headache DisordersNCT06464367 · Yale University | Recruiting | Early Phase 1 | 1 |
| Psilocybin for Prolonged Grief DisorderNCT06724289 · University of Virginia | Recruiting | Early Phase 1 | 1 |
| Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's DiseaseNCT04123314 · Johns Hopkins University | Recruiting | Early Phase 1 | 1 |
| Psilocybin-facilitated Treatment for Chronic PainNCT05068791 · University of Alabama at Birmingham | Recruiting | Early Phase 1 | 1 |
| PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harmNCT06798636 · Imperial College London | Recruiting | Early Phase 1 | 1 |
| Psilocybin for Methamphetamine AddictionNCT06899594 · Kevin Murnane | Recruiting | Early Phase 1 | 1 |
| The Impact of Psilocybin on Pain in Fibromyalgia PatientsNCT06368492 · Maastricht University | Recruiting | Not applicable | 2 |
| "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"NCT06564818 · Cybin IRL Limited | Active, not recruiting | Phase 3 | 45 |
| Efficacy, Safety, and Tolerability of COMP360 in Participants With TRDNCT05624268 · COMPASS Pathways | Completed | Phase 3 | 40 |
| Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRDNCT05711940 · COMPASS Pathways | Active, not recruiting | Phase 3 | 116 |
| Psilocybin for Major Depressive Disorder (MDD)NCT06308653 · Usona Institute | Active, not recruiting | Phase 3 | 29 |
| Psilocybin-Assisted Therapy in Treatment-Resistant DepressionNCT06303739 · University of North Carolina, Chapel Hill | Active, not recruiting | Phase 3 | 1 |
| Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II DisorderNCT06943573 · Lakshmi N Yatham | Not yet recruiting | Phase 3 | 3 |
| Frontline Clinician Psilocybin StudyNCT05163496 · University of Washington | Completed | Phase 3 | 1 |
| Psilocybin-Assisted Physical Therapy in Chronic Low Back PainNCT07306364 · Yale University | Not yet recruiting | Phase 2 | 1 |
| Psilocybin for Methamphetamine Use DisorderNCT07774702 · Peter Hendricks | Not yet recruiting | Phase 2 | 1 |
| PsiloStudy: Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)NCT06853912 · Nathan Brashares Sackett | Active, not recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use DisorderNCT07296094 · Brigham and Women's Hospital | Not yet recruiting | Phase 2 | 1 |
| Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring OpioidsNCT06827054 · Roswell Park Cancer Institute | Not yet recruiting | Phase 2 | 1 |
| NeuroGuard: Psilocybin Trial for Preventing Chemo-induced NeuropathyNCT07227909 · M.D. Anderson Cancer Center | Not yet recruiting | Phase 2 | 1 |
| Psilocybin Therapy for Methamphetamine Use Disorder and HIVNCT07756736 · Nicky Mehtani, MD, MPH | Not yet recruiting | Phase 2 | 1 |
| Neuroplasticity Enhancement From Cognitive Training Reinforced by PsilocybinNCT07721467 · National Institute on Aging (NIA) | Not yet recruiting | Phase 2 | 1 |
| Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic TherapiesNCT07745569 · University of New Mexico | Not yet recruiting | Phase 2 | — |
| Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic MalignanciesNCT07336238 · University of Washington | Active, not recruiting | Phase 2 | 1 |
| PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL)NCT04754061 · Ottawa Hospital Research Institute | Active, not recruiting | Phase 1 / Phase 2 | 2 |
| Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of PsilocybinNCT06341426 · University Health Network, Toronto | Active, not recruiting | Phase 2 | 2 |
| Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced CancerNCT06416085 · University Health Network, Toronto | Active, not recruiting | Phase 2 | 1 |
| The Acute Effects of Psilocybin on Cognition, Memory, and Brain FunctionNCT07079852 · Manoj Doss | Not yet recruiting | Phase 1 / Phase 2 | 1 |
| Psilocybin-Assisted TherapyNCT07332143 · Emory University | Not yet recruiting | Phase 2 | 1 |
| Psilocybin for Treatment-Resistant DepressionNCT06230757 · University of Colorado, Denver | Completed | Phase 2 | 1 |
| Psilocybin-Assisted Therapy as a Treatment for DepressionNCT07582120 · Washington University School of Medicine | Not yet recruiting | Phase 2 | 1 |
| Psilocybin-facilitated Treatment for Cocaine UseNCT02037126 · University of Alabama at Birmingham | Completed | Phase 2 | 1 |
| Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner ViolenceNCT06885996 · University of Calgary | Not yet recruiting | Phase 2 | 2 |
| Psilocybin for Treatment of OCD-2NCT06992999 · Francisco A Moreno | Not yet recruiting | Phase 1 / Phase 2 | 1 |
| Does Psilocybin Require Psychedelic Effects to Treat Depression?NCT05710237 · Centre for Addiction and Mental Health | Completed | Phase 2 | 1 |
| Two Doses of Psilocybin for the Treatment of MDD in Adults With CancerNCT05947383 · Sunstone Medical | Active, not recruiting | Phase 2 | 1 |
| Study of Psilocybin Under Anesthesia Controlled by EEGNCT07479550 · Stanford University | Not yet recruiting | Phase 2 | 1 |
| Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of DepressionNCT07565909 · University of Washington | Not yet recruiting | Phase 2 | — |
| Group PACBT for DepressionNCT07566104 · University of California, Los Angeles | Not yet recruiting | Phase 2 | 1 |
| Psilocybin Therapy for Chronic Low Back PainNCT05351541 · Joshua Woolley, MD, PhD | Active, not recruiting | Phase 1 / Phase 2 | 1 |
| A Study of Psilocybin for Major Depressive Disorder (MDD)NCT03866174 · Usona Institute | Completed | Phase 2 | 11 |
| Psilocybin-Enhanced Psychotherapy for Methamphetamine Use DisorderNCT04982796 · Portland VA Research Foundation, Inc | Active, not recruiting | Phase 1 / Phase 2 | 1 |
| Understanding Music and Mindfulness Preferences in Psilocybin-Assisted PsychotherapyNCT07373535 · Kyle Greenway | Not yet recruiting | Phase 2 | 2 |
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use DisorderNCT07499583 · Indiana University | Not yet recruiting | Phase 1 / Phase 2 | 2 |
| Psilocybin-assisted Therapy for Treatment of Alcohol Use DisorderNCT05416229 · Anders Fink-Jensen, MD, DMSci | Completed | Phase 2 | 1 |
| Precision Phenotyping of Behavioral Risk and Response to Electromagnetic and Psychedelic TherapiesNCT07484906 · University of New Mexico | Withdrawn | Phase 2 | — |
| Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use DisorderNCT04620759 · Johns Hopkins University | Active, not recruiting | Phase 2 | 1 |
| Psilocybin for the Treatment of Veterans With Post-Traumatic Stress DisorderNCT05554094 · Ohio State University | Active, not recruiting | Phase 2 | 1 |
| Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive ImpairmentNCT06041152 · Centre for Addiction and Mental Health | Active, not recruiting | Phase 2 | 1 |
| Inpatient Buprenorphine Induction With Psilocybin for Opioid Use DisorderNCT06005662 · Johns Hopkins University | Withdrawn | Phase 2 | 1 |
| Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice CareNCT04950608 · Yvan Beaussant, MD, MSci | Completed | Phase 2 | 1 |
| Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use DisorderNCT07405606 · Centre for Addiction and Mental Health | Not yet recruiting | Phase 2 | 1 |
| Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)NCT06206265 · TRYP Therapeutics | Active, not recruiting | Phase 2 | 1 |
| Psilocybin AsSisted pSychotherapy for the treatmENt of Gambling disordER : a Pilot StudyNCT07391332 · Nantes University Hospital | Not yet recruiting | Phase 2 | 1 |
| Microdosing Psychedelics to Improve MoodNCT05259943 · Rotem Petranker | Completed | Phase 2 | 1 |
| The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal IdeationNCT05220410 · Sheppard Pratt Health System | Completed | Phase 2 | 1 |
| Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality DisorderNCT05399498 · University of Chicago | Completed | Phase 2 | 1 |
| Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who StutterNCT07296328 · NYU Langone Health | Not yet recruiting | Phase 2 | 1 |
| Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use DisorderNCT05421065 · Peggy C Nopoulos | Active, not recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Therapy for the Treatment of Cancer-Related Anxiety in Patients With Metastatic CancerNCT05847686 · University of Washington | Completed | Phase 1 / Phase 2 | 1 |
| Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ)NCT07210112 · Centre Hospitalier St Anne | Not yet recruiting | Phase 2 | 1 |
| Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electrical Activity MarkersNCT06746441 · Khyber Medical University Peshawar | Completed | Phase 2 | 1 |
| A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive DisorderNCT05733546 · COMPASS Pathways | Active, not recruiting | Phase 2 | 5 |
| The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderNCT05312151 · COMPASS Pathways | Completed | Phase 2 | 3 |
| Open-label Study to Assess the Safety and Efficacy of Psilocybin With Psychotherapy in Adult Participants With FibromyalgiaNCT05128162 · Kevin Boehnke | Completed | Phase 2 | 1 |
| Effects of Psilocybin in Advanced-Stage Cancer Patients With AnxietyNCT00302744 · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Completed | Phase 1 / Phase 2 | 1 |
| Efficacy and Safety of Psilocybin in Treatment-Resistant Major DepressionNCT04670081 · Central Institute of Mental Health, Mannheim | Completed | Phase 2 | 2 |
| Psilocybin Therapy for Depression and Anxiety in Parkinson's DiseaseNCT04932434 · Joshua Woolley, MD, PhD | Completed | Phase 2 | 1 |
| Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept StudyNCT05481736 · COMPASS Pathways | Completed | Phase 2 | 5 |
| Evaluation of Psilocybin (TRP-8802) in the Treatment of Binge Eating DisorderNCT05035927 · TRYP Therapeutics | Completed | Phase 2 | 1 |
| PEX010-Assisted Therapy for Stimulant Use Disorder: A Safety, Feasibility and Efficacy StudyNCT06666010 · Filament Health Corp. | Not yet recruiting | Phase 2 | — |
| Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative MechanismsNCT03429075 · Imperial College London | Completed | Phase 2 | 1 |
| Psilocybin Therapy for Depression in Bipolar II DisorderNCT05065294 · University of California, San Francisco | Active, not recruiting | Phase 2 | 1 |
| Psilocybin-Assisted Psychotherapy in Adults With Alcohol Use Disorder (AUD)NCT05646303 · Clairvoyant Therapeutics | Unknown status | Phase 2 | 12 |
| An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)NCT04433858 · Sheppard Pratt Health System | Active, not recruiting | Phase 2 | 2 |
| Psilocybin for Major Depressive DisorderNCT05675800 · Washington University School of Medicine | Withdrawn | Phase 2 | — |
| Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility StudyNCT04718792 · Anders Fink-Jensen, MD, DMSci | Unknown status | Phase 2 | 1 |
| Psychedelic-assisted Group Program for First RespondersNCT06471959 · Empower Research Inc | Unknown status | Phase 1 / Phase 2 | 1 |
| Psilocybin as a Treatment for Anorexia Nervosa: A Pilot StudyNCT04505189 · Imperial College London | Completed | Phase 1 / Phase 2 | 1 |
| Psilocybin-assisted Therapy for Alcohol Use DisorderNCT06444243 · University of Sydney | Unknown status | Phase 2 | — |
| An Investigation of Psilocybin on Behavioural and Cognitive Symptoms of Adults With Fragile X SyndromeNCT05832255 · Nova Mentis Life Science Corp | Suspended | Phase 2 | 1 |
| The Effect of Psilocybin on MDD Symptom Severity and Synaptic DensityNCT04630964 · Section for Affective Disorders; Northern Stockholm Psychiatry | Completed | Phase 2 | 1 |
| A Study of a Psilocybin Analog (CYB003) in Healthy Participants With and Without Major Depressive DisorderNCT05385783 · Cybin IRL Limited | Completed | Phase 1 / Phase 2 | 3 |
| Psilocybin for Opioid Use Disorder in Patients on Methadone Maintenance With Ongoing Opioid UseNCT05242029 · Johns Hopkins University | Withdrawn | Phase 2 | — |
| The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDDNCT05381974 · Massachusetts General Hospital | Withdrawn | Phase 2 | 1 |
| Psilocybin-Assisted Psychotherapy for Anxiety in People With Stage IV MelanomaNCT00979693 · Multidisciplinary Association for Psychedelic Studies | Withdrawn | Phase 2 | 1 |
| Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSDNCT06141876 · Apex Labs Ltd. | Unknown status | Phase 2 | — |
| The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant DepressionNCT04739865 · COMPASS Pathways | Completed | Phase 2 | 2 |
| Effects and Therapeutic Potential of Psilocybin in Alcohol DependenceNCT01534494 · University of New Mexico | Completed | Phase 2 | 1 |
| Clinical and Mechanistic Effects of Psilocybin in Alcohol Addicted PatientsNCT04141501 · University of Zurich | Completed | Phase 2 | 1 |
| Psilocybin for Treatment-Resistant DepressionNCT05029466 · Brain and Cognition Discovery Foundation | Completed | Phase 2 | 1 |
| Effect of SSRIs on Response to Psilocybin TherapyNCT05594667 · Cybin Therapeutics Inc. | Withdrawn | Phase 2 | 1 |
| Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress DisorderNCT05243329 · Halucenex Life Sciences Inc. | Unknown status | Phase 2 | 1 |
| Evaluation of Psilocybin-assisted Psychotherapy (PaP) for the Treatment of Post-traumatic Stress Disorder (PTSD) in Military VeteransNCT05876481 · Combat Stress | Unknown status | Phase 2 | 1 |
| The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant DepressionNCT03775200 · COMPASS Pathways | Completed | Phase 2 | 25 |
| Safety and Efficacy of Psilocybin for Body Dysmorphic DisorderNCT04656301 · New York State Psychiatric Institute | Completed | Phase 2 | 1 |
| PET Synaptogenesis After Psilocybin In DEpression RecoveryNCT05601648 · Washington University School of Medicine | Withdrawn | Phase 2 | 1 |
| Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use DisorderNCT04410913 · Keith Heinzerling | Active, not recruiting | Phase 2 | 1 |
| A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol DependenceNCT02061293 · NYU Langone Health | Completed | Phase 2 | 2 |
| The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression.NCT04433845 · Sheppard Pratt Health System | Unknown status | Phase 2 | 1 |
| Prophylactic Effects of Psilocybin on Chronic Cluster HeadacheNCT04280055 · Gitte Moos Knudsen | Terminated | Phase 1 / Phase 2 | 1 |
| Evaluation of Psilocybin in Anorexia Nervosa: Safety and EfficacyNCT04661514 · University of California, San Diego | Completed | Phase 2 | 1 |
| Assessing the Efficacy of Micro-dosed Psilocybin on Reducing Anxiety & Depression Levels in AdultsNCT04989972 · Wake Network, Inc. | Withdrawn | Phase 2 | 1 |
| Psilocybin Versus Ketamine in Treatment-Resistant DepressionNCT05383313 · National Institute of Mental Health, Czech Republic | Unknown status | Phase 2 | 1 |
| Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of ConceptNCT03715127 · University of Zurich | Completed | Phase 2 | 1 |
| Effects of Psilocybin in Major Depressive DisorderNCT03181529 · Johns Hopkins University | Completed | Phase 2 | 1 |
| The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive DisorderNCT04593563 · Maryland Oncology Hematology, PA | Unknown status | Phase 2 | 1 |
| Psilocybin in Depression Resistant to Standard TreatmentsNCT04959253 · King's College London | Unknown status | Phase 2 | 1 |
| Persisting Effects of PsilocybinNCT02971605 · Johns Hopkins University | Completed | Phase 1 / Phase 2 | 1 |
| Psychopharmacology of Psilocybin in Cancer PatientsNCT00465595 · Johns Hopkins University | Completed | Phase 2 | 1 |
| Psilocybin and DepressionNCT03380442 · University of Helsinki | Unknown status | Phase 2 | — |
| Psilocybin as a Novel Therapy for Residual AnhedoniaNCT07607938 · NYU Langone Health | Not yet recruiting | Phase 1 | 1 |
| Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal CancersNCT05220046 · University of Nebraska | Completed | Phase 1 | 1 |
| Psilocybin Effects on Healthy Aging Biomarkers and Purpose in LifeNCT07719088 · Charles Raison | Not yet recruiting | Phase 1 | 1 |
| Safety for Home Administration of Microdose Psilocybin UseNCT06450210 · Johns Hopkins University | Completed | Phase 1 | 1 |
| Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar DepressionNCT06506019 · University Health Network, Toronto | Active, not recruiting | Phase 1 | 1 |
| Psilocybin Brain Stimulation and Imaging Pilot StudyNCT06835699 · Johns Hopkins University | Completed | Phase 1 | 1 |
| Psilocybin for Treatment-Resistant Depression in AutismNCT06731621 · Centre for Addiction and Mental Health | Active, not recruiting | Phase 1 | 1 |
| Psilocybin After Trauma Surgery for PainNCT07406828 · Trent Emerick | Not yet recruiting | Phase 1 | 1 |
| Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility StudyNCT06988319 · Oregon Health and Science University | Not yet recruiting | Phase 1 | 1 |
| Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSDNCT07275970 · Scottsdale Research Institute | Active, not recruiting | Phase 1 | 1 |
| Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCDNCT06299319 · Centre for Addiction and Mental Health | Active, not recruiting | Phase 1 | 1 |
| Identification of a Safe and Non-Psychedelic Dose of PsilocybinNCT07710027 · Diamond Therapeutics Inc. | Completed | Phase 1 | 1 |
| The Effects of Psilocybin on Social ConnectednessNCT07693153 · Yale University | Not yet recruiting | Phase 1 | 1 |
| Consciousness and Psilocybin Effects on Well-Being: The CoPEWell StudyNCT07360301 · University of Wisconsin, Madison | Not yet recruiting | Phase 1 | 1 |
| Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy SubjectsNCT06884514 · University Hospital, Basel, Switzerland | Completed | Phase 1 | 1 |
| A Study of Psilocybin for PTSDNCT06407635 · Johns Hopkins University | Active, not recruiting | Phase 1 | 1 |
| Neural and Physiological Correlates of Psychedelic Sub-statesNCT05698511 · Robin Carhart-Harris, PhD, MA | Active, not recruiting | Phase 1 | 1 |
| Effects of Repeated Psilocybin Dosing in OCDNCT05370911 · Yale University | Active, not recruiting | Phase 1 | 2 |
| Psilocybin-assisted CBT for DepressionNCT05227612 · University of California, Los Angeles | Completed | Phase 1 | 1 |
| Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use DisorderNCT05322954 · University of Wisconsin, Madison | Terminated | Phase 1 | 1 |
| The Effects of Psilocybin in Healthy Volunteers: Psychological, Biochemical and Electrophysiological Biomarkers.NCT07433452 · Gabriella Gobbi | Not yet recruiting | Phase 1 | — |
| A Study Assessing Brain Activity, Safety, Tolerability, and Pharmacokinetics Following Multiple Doses of MLS101 (Psilocybin) in Healthy VolunteersNCT07050368 · MycoMedica Life Sciences PBC | Completed | Phase 1 | 1 |
| Psilocybin-assisted Therapy for Phantom Limb PainNCT05224336 · University of California, San Diego | Completed | Phase 1 | 1 |
| Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy HumansNCT06081179 · University of Zurich | Completed | Phase 1 | 1 |
| Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive DisorderNCT03554174 · Yale University | Active, not recruiting | Phase 1 | 1 |
| A Second Psilocybin Group Therapy for the Treatment of Cancer-Related Anxiety in Partial Responders With Metastatic CancerNCT06644170 · University of Washington | Completed | Phase 1 | 1 |
| PRoMiSS: Psilocybin and the Role of Music in Set and SettingNCT07180108 · Johns Hopkins University | Enrolling by invitation | Phase 1 | 1 |
| Effects of Psilocybin in Post-Treatment Lyme DiseaseNCT05305105 · Johns Hopkins University | Completed | Phase 1 | 1 |
| Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic PainNCT05506982 · Emory University | Completed | Phase 1 | 2 |
| Visual Surround Suppression and Perceptual Expectation Under PsilocybinNCT04424225 · University of Minnesota | Terminated | Phase 1 | 1 |
| A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple Doses of MLS101 in Healthy ParticipantsNCT06643637 · MycoMedica Life Sciences PBC | Completed | Phase 1 | 1 |
| Comparing the Effects of Psilocin and Psilocybin in Healthy AdultsNCT05317689 · University of California, San Francisco | Active, not recruiting | Phase 1 | 1 |
| Psilocybin With Intracranial Neural SensingNCT06919640 · Joshua Woolley, MD, PhD | Enrolling by invitation | Phase 1 | 1 |
| Consciousness, Psilocybin, and Well-BeingNCT05592379 · University of Wisconsin, Madison | Completed | Phase 1 | 1 |
| Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy SubjectsNCT05523401 · University Hospital, Basel, Switzerland | Completed | Phase 1 | 1 |
| Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.NCT03356483 · Yale University | Completed | Phase 1 | 1 |
| PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related BurnoutNCT05557643 · University of Utah | Completed | Phase 1 | 1 |
| PsilOCD: A Pharmacological-Challenge Feasibility StudyNCT06258031 · Imperial College London | Completed | Phase 1 | 1 |
| A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MLS101 in Healthy ParticipantsNCT06326606 · MycoMedica Life Sciences PBC | Completed | Phase 1 | 1 |
| Psilocybin for Treatment of Obsessive Compulsive DisorderNCT03300947 · University of Arizona | Completed | Phase 1 | 1 |
| Effects of Psilocybin-facilitated Experience on the Psychology and Effectiveness of Professional Leaders in ReligionNCT02243813 · Johns Hopkins University | Completed | Phase 1 | 1 |
| Repeat Dosing of Psilocybin in Migraine HeadacheNCT04218539 · Yale University | Completed | Phase 1 | 1 |
| Comparative Acute Effects of LSD, Psilocybin and MescalineNCT04227756 · University Hospital, Basel, Switzerland | Completed | Phase 1 | 1 |
| Safety and Tolerability of Psilocybin in Post-Traumatic Stress DisorderNCT05562973 · Johns Hopkins University | Withdrawn | Phase 1 | — |
| Psilocybin for the Treatment of Cluster HeadacheNCT02981173 · Yale University | Completed | Phase 1 | 1 |
| Psilocybin for the Treatment of Migraine HeadacheNCT03341689 · Yale University | Completed | Phase 1 | 1 |
| Effects of Psilocybin in Concussion HeadacheNCT03806985 · Yale University | Terminated | Phase 1 | 1 |
| Evaluation of Safety, Rate and Extent of Absorption of Psilocin MucateNCT06035900 · Lobe Sciences Ltd. | Completed | Phase 1 | 1 |
| An Evaluation of Psilocybin's Effect on Cardiac Repolarization and the Effect of Food on Psilocybin's PharmacokineticsNCT05478278 · Usona Institute | Completed | Phase 1 | 1 |
| Pilot RECAP Study in Healthy VolunteersNCT04842045 · University of Wisconsin, Madison | Completed | Phase 1 | 1 |
| Bioavailability Study of Psilocybin in Normal AdultsNCT05467761 · University of Wisconsin, Madison | Withdrawn | Phase 1 | 1 |
| Effects of Psilocybin in Anorexia NervosaNCT04052568 · Johns Hopkins University | Completed | Phase 1 | 1 |
| Northwest Therapies Trauma Psilocybin Study Compassionate Use StudyNCT05042466 · NWTraumatherapies | Unknown status | Phase 1 | 1 |
| Phase 1b Study in Patients With Short-Lasting Unilateral Neuralgiform Headache Attacks (SUNHA)NCT04905121 · Beckley Psytech Limited | Terminated | Phase 1 | 1 |
| The Effects of Psilocybin-Facilitated Experience on the Psychology and Effectiveness of Religious ProfessionalsNCT02421263 · NYU Langone Health | Completed | Phase 1 | 1 |
| Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS SurvivorsNCT02950467 · Joshua Woolley | Completed | Phase 1 | 1 |
| Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy SubjectsNCT03912974 · University Hospital, Basel, Switzerland | Completed | Phase 1 | 1 |
| UW Psilocybin Pharmacokinetics StudyNCT02163707 · University of Wisconsin, Madison | Completed | Phase 1 | 1 |
| Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term MeditatorsNCT02145091 · Johns Hopkins University | Completed | Phase 1 | 1 |
| Psilocybin and Spiritual PracticeNCT00802282 · Johns Hopkins University | Completed | Phase 1 | 1 |
| Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term MeditatorsNCT01988311 · Johns Hopkins University | Completed | Phase 1 | 1 |
| Psilocybin Microdosing on Cognition, Mood and Quality of LifeNCT07449351 · Yale University | Not yet recruiting | Early Phase 1 | 1 |
| Safety Profile of Psilocybin for Cocaine Use DisorderNCT06102434 · University of California, Los Angeles | Suspended | Early Phase 1 | 1 |
| Effects of Psilocybin in Obsessive Compulsive DisorderNCT05546658 · Johns Hopkins University | Active, not recruiting | Early Phase 1 | 1 |
| Exploratory Study of Low Dose PsilocybinNCT05227742 · University of Alabama at Birmingham | Withdrawn | Early Phase 1 | 1 |
| Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)NCT06760533 · NYU Langone Health | Not yet recruiting | Early Phase 1 | 1 |
| Precision Functional Brain Mapping in PsilocybinNCT04501653 · Washington University School of Medicine | Completed | Early Phase 1 | 1 |
| Study of Psilocybin Enhanced Group Psychotherapy in Patients With CancerNCT04522804 · University of Utah | Completed | Early Phase 1 | 1 |
| A Community of Practice Program With Psilocybin-assisted Therapy for End-of-Life PatientsNCT05958758 · The Roots to Thrive Society for Psychedelic Therapy | Unknown status | Early Phase 1 | — |
| Mood and Cognitive Effects of Psilocybin in Healthy ParticipantsNCT05252598 · Optimi Health Corporation | Withdrawn | Early Phase 1 | — |
| Direct Comparison of Altered States of Consciousness Induced by LSD and PsilocybinNCT03604744 · University Hospital, Basel, Switzerland | Completed | Early Phase 1 | 1 |
| Psilocybin Cancer Anxiety StudyNCT00957359 · NYU Langone Health | Completed | Early Phase 1 | 1 |
| Psilocybin-Assisted Group Integration Psychotherapy for Treatment-Resistant DepressionNCT07737990 · Joshua Rosenblat | Enrolling by invitation | Not applicable | 1 |
| Psilocybin in Functional Neurological DisorderNCT05723276 · King's College London | Completed | Not applicable | 1 |
| Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic PsychedelicsNCT06624137 · Yale University | Terminated | N/A | 2 |
| PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive DisorderNCT04353921 · Usona Institute | Terminated | N/A | 1 |
| Retrospective Observational Study of Intensity Effects in Psychedelic-assisted TreatmentNCT07164287 · University Hospital, Geneva | Active, not recruiting | N/A | 1 |
| Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on AlcoholismNCT07189988 · Healing Advocacy Fund | Active, not recruiting | N/A | 1 |
| Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given PsilocybinNCT07164755 · King's College London | Active, not recruiting | N/A | 1 |
| Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic SeizuresNCT06647056 · Centre Hospitalier Universitaire de Nīmes | Completed | Not applicable | 1 |
| Effect of Psilocybin on the Positive Valence System in Treatment-resistant DepressionNCT06650800 · Centre Hospitalier Universitaire de Nīmes | Completed | Not applicable | 1 |
| Psilocybin in Adults With and Without Autism Spectrum DisorderNCT05651126 · King's College London | Completed | Not applicable | 1 |
| Low-Income Group Psilocybin Assisted Therapy for DepressionNCT06372197 · Matthew Hicks | Completed | Not applicable | 1 |
| Optimizing Microdosing and MeditationNCT06560658 · National University of Natural Medicine | Withdrawn | Not applicable | 1 |
| Psilocybin-facilitated Smoking Cessation Treatment: A Pilot StudyNCT01943994 · Johns Hopkins University | Completed | Not applicable | 2 |
| The Role of Personal Experience for the Therapeutic Attitude in the Context of Substance-assisted Therapy TrainingNCT05570708 · Felix Mueller | Enrolling by invitation | Not applicable | 1 |
| Psilocybin-assisted Interpersonal Therapy for DepressionNCT05581797 · University of Otago | Completed | Not applicable | 1 |
| Psilocybin in Alcohol Use Disorder With Comorbid DepressionNCT06235411 · Centre Hospitalier Universitaire de Nīmes | Completed | Not applicable | 1 |
| The Effects of Psilocybin on Shared Experience in Film ProcessingNCT06529939 · Western University, Canada | Unknown status | Not applicable | — |
| Psilocybin in Patients With Fibromyalgia: EEG-measured Brain Biomarkers of ActionNCT05548075 · Imperial College London | Unknown status | N/A | 1 |
| Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)NCT04519957 · COMPASS Pathways | Completed | N/A | 8 |
| Naturalistic Study of Microdosing With PsilocybinNCT05160220 · National Council of Scientific and Technical Research, Argentina | Completed | Not applicable | 1 |
| Characterization of Altered Waking States of Consciousness in Healthy HumansNCT03853577 · University of Zurich | Completed | Not applicable | 1 |
| Beyond the Self and Back: Neuropharmacological Mechanisms Underlying the Dissolution of the SelfNCT03736980 · University of Zurich | Completed | Not applicable | — |