Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
NCT06624137 · Yale University
What it is testing
Summary
Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.
What counts as success
Primary outcome measures
Hierarchial Gaussian Filter (HGF)-estimated average precision-weighted prediction error change in the conditioned hallucinations and probabilistic reversal learning tasks
Measured over Immediately post drug administration (when psychologically acceptable), 1 day post drug administration, 5-14 days post drug administration, and 4-6 weeks post drug administration
Auditory and visual conditioned hallucination rate change
Measured over Immediately post drug administration (when psychologically acceptable), 1 day post drug administration, 5-14 days post drug administration, and 4-6 weeks post drug administration
Perseverative and jumping-to-conclusion error total change in probabilistic reversal learning task
Measured over Immediately post drug administration (when psychologically acceptable), 1 day post drug administration, 5-14 days post drug administration, and 4-6 weeks post drug administration
Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) score change
Measured over 1 day post drug administration, 5-14 days post drug administration, and 4-6 weeks post drug administration
Southampton Mindfulness Questionnaire (SMQ) score change
Measured over 1 day post drug administration, 5-14 days post drug administration, and 4-6 weeks post drug administration
HGF-estimated ratio of perceptual belief-to-sensory evidence weighting change
Measured over Immediately post drug administration (when psychologically acceptable), 1 day post drug administration, 5-14 days post drug administration, and 4-6 weeks post drug administration
Aberrant Salience Inventory (ASI) score change
Measured over 1 day post drug administration, 5-14 days post drug administration, and 4-6 weeks post drug administration
Change in the exponent of the 1/f power spectrum law from resting state EEG
Measured over Period of peak drug effect and 1 day after drug administration
Change in resting state delta, alpha, theta, low gamma, medium gamma, and high gamma bands
Measured over Period of peak drug effect and 1 day after drug administration
A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.
Who can take part
Eligibility, as published
Where
2 study sites
| Facility | City | Region | Country |
|---|---|---|---|
| Connecticut Mental Health Center | Hamden | Connecticut | United States |
| West Haven VA Medical Center | West Haven | Connecticut | United States |
On the registry
Contact the trial directly
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NCT06624137 on ClinicalTrials.gov →
Last updated in the registry 2026-07-09. Registry records change; this page reflects the data build of 2026-08-25.
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