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Indication

Major Depression

16 registered trials testing LSD, Psilocybin, Ketamine, DMT for this indication, 5 recruiting now.

16
Registered trials
5
Recruiting
1
In Phase 3

Substances tested

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This registry is rebuilt every day. If no trial is recruiting for you today, that can change within weeks.

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Trials

All 16 trials for Major Depression

TrialStatusPhaseSubstanceSites
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionNCT07226232 · VA Office of Research and DevelopmentRecruitingPhase 3psilocybin5
Inhaled DMT for Major Depressive DisorderNCT07562191 · Universidade Federal do Rio Grande do NorteRecruitingPhase 2dmt5
Ketamine Alcohol (in Treatment-Resistant Depression)NCT02122562 · Mark NiciuRecruitingPhase 2ketamine1
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionNCT03973268 · National Institute of Mental Health (NIMH)RecruitingPhase 1ketamine1
University of Iowa Interventional Psychiatry Service Patient RegistryNCT04480918 · Mark NiciuRecruitingN/Aketamine1
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.NCT03156504 · Mayo ClinicCompletedPhase 4ketamine4
Research Study for Major Depressive Disorder: Investigation of Glutamate MedicationsNCT00419003 · Baylor College of MedicineCompletedPhase 4ketamine1
Effects of Sevoflurane and Ketamine on QT in Electroconvulsive TherapyNCT01870219 · Inonu UniversityCompletedPhase 4ketamine1
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic TherapiesNCT07745569 · University of New MexicoNot yet recruitingPhase 2psilocybin—
Study of Psilocybin Under Anesthesia Controlled by EEGNCT07479550 · Stanford UniversityNot yet recruitingPhase 2psilocybin1
Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant DepressionNCT02914769 · Universidade Federal do Rio Grande do NorteCompletedPhase 1 / Phase 2dmt1
Study of Depression-Ketamine-Brain FunctionNCT01135758 · Markus KOSELTerminatedPhase 2ketamine1
Shortened LSD Intervention for Major Depressive DisorderNCT07503002 · Johns Hopkins UniversityNot yet recruitingPhase 1lsd1
Open-Label Dose-Ranging Study of Oral SM-001 in Healthy AdultsNCT05894902 · Advanced Integrative Medical Science InstituteUnknown statusPhase 1dmt1
Treatment Response In ECT PatientsNCT07463911 · Nurdan SağbaşActive, not recruitingN/Aketamine1
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in DepressionNCT01309581 · James MurroughTerminatedNot applicableketamine1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.