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Indication

Depression - Major Depressive Disorder

17 registered trials testing Psilocybin, Ketamine, DMT, Ibogaine for this indication, 9 recruiting now.

Sponsors register this under 2 different names, all collected here: Depression - Major Depressive Disorder · Depression / Major Depressive Disorder

17
Registered trials
9
Recruiting
1
In Phase 3

Substances tested

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This registry is rebuilt every week from the federal registry. If no trial is recruiting for you today, that can change within weeks.

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Trials

All 17 trials for Depression - Major Depressive Disorder

TrialStatusPhaseSubstanceSites
Biomarker-Guided Antidepressant SelectionNCT07680140 · Weill Medical College of Cornell UniversityRecruitingPhase 4ketamine1
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL LimitedRecruitingPhase 3psilocybin79
Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ)NCT07210112 · Centre Hospitalier St AnneRecruitingPhase 2psilocybin1
Psilocybin to Treat Depression in Spinal Cord InjuryNCT07251491 · James J. Peters Veterans Affairs Medical CenterRecruitingPhase 1 / Phase 2psilocybin1
Mindfulness-based Psilocybin Therapy for PTSDNCT07104916 · Anthony P KingRecruitingPhase 2psilocybin1
Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic EffectsNCT07490353 · Medical University of ViennaRecruitingPhase 1psilocybin1
Open-Label Psilocybin Study in Transdiagnostic PopulationNCT06442423 · Yale UniversityRecruitingPhase 1psilocybin1
ACT_for Alcohol Use Disorder and DepressionNCT06620276 · Centre hospitalier de l'Université de Montréal (CHUM)RecruitingNot applicableketamine1
Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant DepressionNCT07422519 · Hospital Universitari Vall d'Hebron Research InstituteRecruitingNot applicableketamine1
Group PACBT for DepressionNCT07566104 · University of California, Los AngelesNot yet recruitingPhase 2psilocybin1
Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal DistressNCT07810023 · Endeavor HealthEnrolling by invitationNot applicableketamine1
Trifecta Research StudyNCT07717866 · Axial Therapeutic ResearchActive, not recruitingN/Admt, ibogaine1
Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and AnhedoniaNCT07199179 · University Hospital, MontpellierActive, not recruitingN/Aketamine1
Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given PsilocybinNCT07164755 · King's College LondonActive, not recruitingN/Apsilocybin1
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy RecommendationNCT07097025 · Dr.Yoav DomanyCompletedN/Aketamine2
Chart Review of Patients Undergoing Ketamine Treatments for DepressionNCT07099235 · Sunnybrook Health Sciences CentreCompletedN/Aketamine1
Sustained Ketamine Effectiveness for Suicidal IdeationNCT06806475 · University Hospital, MontpellierCompletedN/Aketamine1

Records from ClinicalTrials.gov API v2, data build 2026-10-06. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.