Skip to content
lsd.com

Indication

Depression - Major Depressive Disorder

16 registered trials testing Psilocybin, Ketamine, DMT, Ibogaine for this indication, 7 recruiting now.

16
Registered trials
7
Recruiting
1
In Phase 3

Substances tested

Being studied with

Stay told

When a new trial opens

Research alerts

Get a notification when a trial for Depression - Major Depressive Disorder trials starts recruiting

This registry is rebuilt every day. If no trial is recruiting for you today, that can change within weeks.

This form sends your email address and the topic of this page to Brevo, our email provider, which stores them on servers in the European Union. We never sell that address, never share it with anyone, and never use it for advertising. One email deletes it. What is held, and where.

Trials

All 16 trials for Depression - Major Depressive Disorder

TrialStatusPhaseSubstanceSites
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderNCT06793397 · Cybin IRL LimitedRecruitingPhase 3psilocybin68
Psilocybin to Treat Depression in Spinal Cord InjuryNCT07251491 · James J. Peters Veterans Affairs Medical CenterRecruitingPhase 1 / Phase 2psilocybin1
Mindfulness-based Psilocybin Therapy for PTSDNCT07104916 · Anthony P KingRecruitingPhase 2psilocybin1
Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic EffectsNCT07490353 · Medical University of ViennaRecruitingPhase 1psilocybin1
Open-Label Psilocybin Study in Transdiagnostic PopulationNCT06442423 · Yale UniversityRecruitingPhase 1psilocybin1
ACT_for Alcohol Use Disorder and DepressionNCT06620276 · Centre hospitalier de l'Université de Montréal (CHUM)RecruitingNot applicableketamine1
Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant DepressionNCT07422519 · Hospital Universitari Vall d'Hebron Research InstituteRecruitingNot applicableketamine1
Biomarker-Guided Antidepressant SelectionNCT07680140 · Weill Medical College of Cornell UniversityNot yet recruitingPhase 4ketamine1
Group PACBT for DepressionNCT07566104 · University of California, Los AngelesNot yet recruitingPhase 2psilocybin1
Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ)NCT07210112 · Centre Hospitalier St AnneNot yet recruitingPhase 2psilocybin1
Trifecta Research StudyNCT07717866 · Axial Therapeutic ResearchActive, not recruitingN/Admt, ibogaine1
Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and AnhedoniaNCT07199179 · University Hospital, MontpellierActive, not recruitingN/Aketamine1
Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given PsilocybinNCT07164755 · King's College LondonActive, not recruitingN/Apsilocybin1
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy RecommendationNCT07097025 · Dr.Yoav DomanyCompletedN/Aketamine2
Chart Review of Patients Undergoing Ketamine Treatments for DepressionNCT07099235 · Sunnybrook Health Sciences CentreCompletedN/Aketamine1
Sustained Ketamine Effectiveness for Suicidal IdeationNCT06806475 · University Hospital, MontpellierCompletedN/Aketamine1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.