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RecruitingPhase 1

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

NCT06070649 · Yale University

Recruiting
Status
Accepting participants
Phase 1
Phase
63
Target enrolment
1
Study sites
1 US states

What it is testing

Summary

This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • Safety and tolerability of DMT in women and men with AUD

    Measured over Day 0 through Day 56

  • The effects of DMT, plus psychotherapy, on alcohol consumption

    Measured over Day 0 through Day 56

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

21 Years to 65 Years
Ages
All
Sex
Not accepted
Healthy volunteers
Inclusion Criteria: * Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) diagnosis of Alcohol Use Disorder * Medically healthy * Ability to provide consent Exclusion Criteria: * Unstable medical conditions

Where

1 study site

FacilityCityRegionCountry
Connecticut Mental Health CenterNew HavenConnecticutUnited States

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT06070649 on ClinicalTrials.gov →

Last updated in the registry 2026-08-18. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits