Lysergic acid diethylamide

LSD

50 registered trials on the federal registry, 5 of them in Phase 3, and 8 recruiting now.

Registered trials

Recruiting

In Phase 3

With results posted

Open now

8 recruiting LSD trials

Trial	Status	Phase	Sites
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc.	Recruiting	Phase 3	30
LSD Treatment for Persons With Alcohol Use DisorderNCT05474989 · Felix Mueller	Recruiting	Phase 2	2
Lysergic Acid Diethylamide (LSD) in Palliative CareNCT05883540 · University Hospital, Basel, Switzerland	Recruiting	Phase 2	4
LSD to Improve Cluster Headache Impact TrialNCT05477459 · Radboud University Medical Center	Recruiting	Phase 2	2
Lysergic Acid Diethylamide (LSD) as Treatment for Cluster HeadacheNCT03781128 · University Hospital, Basel, Switzerland	Recruiting	Phase 2	1
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy ParticipantsNCT06899334 · University Hospital, Basel, Switzerland	Recruiting	Phase 1	1
Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSDNCT07461532 · Northern Jiangsu People's Hospital	Recruiting	Not applicable	1
Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSDNCT07309471 · University Hospital, Basel, Switzerland	Recruiting	Not applicable	1

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All 50 LSD trials

Trial	Status	Phase	Sites
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)NCT07592689 · Definium Therapeutics US, Inc.	Recruiting	Phase 3	30
LSD Treatment for Persons With Alcohol Use DisorderNCT05474989 · Felix Mueller	Recruiting	Phase 2	2
Lysergic Acid Diethylamide (LSD) in Palliative CareNCT05883540 · University Hospital, Basel, Switzerland	Recruiting	Phase 2	4
LSD to Improve Cluster Headache Impact TrialNCT05477459 · Radboud University Medical Center	Recruiting	Phase 2	2
Lysergic Acid Diethylamide (LSD) as Treatment for Cluster HeadacheNCT03781128 · University Hospital, Basel, Switzerland	Recruiting	Phase 2	1
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy ParticipantsNCT06899334 · University Hospital, Basel, Switzerland	Recruiting	Phase 1	1
Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSDNCT07461532 · Northern Jiangsu People's Hospital	Recruiting	Not applicable	1
Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSDNCT07309471 · University Hospital, Basel, Switzerland	Recruiting	Not applicable	1
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)NCT06809595 · Definium Therapeutics US, Inc.	Active, not recruiting	Phase 3	36
A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)NCT06941844 · Definium Therapeutics US, Inc.	Active, not recruiting	Phase 3	22
A Phase 3 Trial of DT120 for Generalized Anxiety Disorder (Voyage)NCT06741228 · Definium Therapeutics US, Inc.	Active, not recruiting	Phase 3	34
Sodium Lactate and Brain Relaxation (LSD)NCT04488874 · Centre Hospitalier Universitaire de Besancon	Completed	Phase 3	1
Safety and Efficacy of Low Dose MM120 for ADHD Proof of Concept TrialNCT05200936 · Definium Therapeutics US, Inc.	Completed	Phase 2	2
A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety SymptomsNCT05407064 · Definium Therapeutics US, Inc.	Completed	Phase 2	22
LSD Therapy for Persons Suffering From Major DepressionNCT03866252 · University Hospital, Basel, Switzerland	Completed	Phase 2	1
Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related AnxietyNCT00920387 · Multidisciplinary Association for Psychedelic Studies	Completed	Phase 2	1
The Effect of LSD on Neural Synchrony, Prosocial Behavior, and Relationship QualityNCT05670184 · Maastricht University	Unknown status	Phase 1 / Phase 2	1
LSD Treatment in Persons Suffering From Anxiety Symptoms in Severe Somatic Diseases or in Psychiatric Anxiety DisordersNCT03153579 · University Hospital, Basel, Switzerland	Completed	Phase 2	2
Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) PatientsNCT00736307 · Royan Institute	Completed	Phase 1 / Phase 2	2
Shortened LSD Intervention for Major Depressive DisorderNCT07503002 · Johns Hopkins University	Not yet recruiting	Phase 1	1
Effect of Ketanserin, Olanzapine, and Lorazepam After LSD Administration on the Acute Response to LSD in Healthy SubjectsNCT05964647 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Effects of LSD on Neuroplasticity in Healthy SubjectsNCT05177419 · University of Fribourg	Completed	Phase 1	1
Effects of SERT Inhibition on the Subjective Response to LSD in Healthy SubjectsNCT05175430 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
LSD Base and LSD Tartrate Bioequivalence and Bioavailability in Healthy SubjectsNCT04865653 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Mood Effects of Serotonin AgonistsNCT03790358 · University of Chicago	Completed	Phase 1	2
Comparative Acute Effects of LSD, Psilocybin and MescalineNCT04227756 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Mood Effects of Serotonin Agonists ExtendedNCT03934710 · University of Chicago	Completed	Phase 1	1
A Dose-Ranging Study of 50 µg to 100 µg LSD in Healthy VolunteersNCT05674669 · Eleusis Therapeutics	Completed	Phase 1	1
Effects of MDMA Co-administration on the Response to LSD in Healthy SubjectsNCT04516902 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Effect of Ketanserin After LSD AdministrationNCT04558294 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
A Double-blind, Placebo-controlled Study to Evaluate Very Low Dose LSD in Healthy Volunteers Aged 55-75 YearsNCT04421105 · Eleusis Therapeutics	Completed	Phase 1	—
Mood Effects of Serotonin Agonists: DepressionNCT07017478 · University of Chicago	Completed	Early Phase 1	1
Drug Effects on Mood and Behavior - ExpectancyNCT07061886 · University of Chicago	Completed	Early Phase 1	1
LSD Occupancy of the Serotonin 2A Receptor in the Human BrainNCT05953038 · Rigshospitalet, Denmark	Active, not recruiting	Early Phase 1	1
Direct Comparison of Altered States of Consciousness Induced by LSD and PsilocybinNCT03604744 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Role of the Serotonin 5-HT2A Receptor in LSD-induced Altered States of Consciousness (LDR-Study)NCT03321136 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Role of Dopamine, Serotonin and 5-HT2A Receptors in Emotion ProcessingNCT03019822 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Psychological, Physiological, Endocrine, and Pharmacokinetic Effects of LSD in a Controlled StudyNCT01878942 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Neuronal Correlates of Altered States of ConsciousnessNCT02308969 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic PsychedelicsNCT06624137 · Yale University	Terminated	N/A	2
LSD-Perceptual-Choice-StudyNCT05976698 · University Hospital, Basel, Switzerland	Completed	Not applicable	1
Long-term Efficacy and Safety of LSD Versus TIPS for Cirrhotic Portal Hypertension Bleeding and HypersplenismNCT07490405 · Northern Jiangsu People's Hospital	Not yet recruiting	N/A	1
Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)NCT07585786 · Northern Jiangsu People's Hospital	Not yet recruiting	N/A	—
Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)NCT07588334 · Northern Jiangsu People's Hospital	Not yet recruiting	N/A	1
Acute Effects of Aerobic Exercise Intensity on Lower-Limb Muscle Strength and Power in Youth GymnastsNCT07415395 · Chaoran Han	Completed	Not applicable	1
Retrospective Observational Study of Intensity Effects in Psychedelic-assisted TreatmentNCT07164287 · University Hospital, Geneva	Active, not recruiting	N/A	1
Microdosing LSD in Women With Premenstrual DisordersNCT07189299 · Friederike Holze	Not yet recruiting	Not applicable	1
Salivary Oxytocin as a Biomarker in Psychedelic Assisted PsychotherapyNCT06557239 · Tatiana Aboulafia Brakha	Completed	N/A	1
The Role of Personal Experience for the Therapeutic Attitude in the Context of Substance-assisted Therapy TrainingNCT05570708 · Felix Mueller	Enrolling by invitation	Not applicable	1
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy VolunteersNCT02451072 · Psychiatric University Hospital, Zurich	Completed	Not applicable	1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. A trial counts for LSD only where the substance is named in its title, summary or interventions. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.