Dimethyltryptamine and ayahuasca

DMT

69 registered trials on the federal registry, and 12 recruiting now.

Registered trials

Recruiting

In Phase 3

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Open now

12 recruiting DMT trials

Trial	Status	Phase	Sites
Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical TrialNCT07747324 · University of Sao Paulo	Recruiting	Phase 1 / Phase 2	1
Inhaled DMT for Major Depressive DisorderNCT07562191 · Universidade Federal do Rio Grande do Norte	Recruiting	Phase 2	5
Ayahuasca, Esketamine and PTSDNCT07317206 · University of Sao Paulo	Recruiting	Phase 2	1
The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)NCT06070649 · Yale University	Recruiting	Phase 1	1
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in HumansNCT06671977 · Deepak C. D'Souza	Recruiting	Phase 1	1
Acute Effects of Intravenous 5-MeO-DMT in Healthy ParticipantsNCT07444788 · University Hospital, Basel, Switzerland	Recruiting	Phase 1	1
Investigation of Psychedelic Effects in Psychoactive SubstancesNCT06772753 · Johns Hopkins University	Recruiting	Phase 1	1
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy ParticipantsNCT06899334 · University Hospital, Basel, Switzerland	Recruiting	Phase 1	1
Pharmacokinetics of GH001 Delivered Via a Proprietary Aerosol Delivery Device in Healthy SubjectsNCT06511947 · GH Research Ireland Limited	Recruiting	Phase 1	1
Antidepressant Response of DMT Masked With PropofolNCT06927076 · University Hospital, Basel, Switzerland	Recruiting	Not applicable	1
Ayahuasca, Esketamine and Body Image PerceptionNCT07317219 · University of Sao Paulo	Recruiting	Not applicable	1
Ayahuasca, Esketamine and Premenstrual SymptomsNCT07317232 · University of Sao Paulo	Recruiting	Not applicable	1

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All 69 DMT trials

Trial	Status	Phase	Sites
Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical TrialNCT07747324 · University of Sao Paulo	Recruiting	Phase 1 / Phase 2	1
Inhaled DMT for Major Depressive DisorderNCT07562191 · Universidade Federal do Rio Grande do Norte	Recruiting	Phase 2	5
Ayahuasca, Esketamine and PTSDNCT07317206 · University of Sao Paulo	Recruiting	Phase 2	1
The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)NCT06070649 · Yale University	Recruiting	Phase 1	1
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in HumansNCT06671977 · Deepak C. D'Souza	Recruiting	Phase 1	1
Acute Effects of Intravenous 5-MeO-DMT in Healthy ParticipantsNCT07444788 · University Hospital, Basel, Switzerland	Recruiting	Phase 1	1
Investigation of Psychedelic Effects in Psychoactive SubstancesNCT06772753 · Johns Hopkins University	Recruiting	Phase 1	1
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy ParticipantsNCT06899334 · University Hospital, Basel, Switzerland	Recruiting	Phase 1	1
Pharmacokinetics of GH001 Delivered Via a Proprietary Aerosol Delivery Device in Healthy SubjectsNCT06511947 · GH Research Ireland Limited	Recruiting	Phase 1	1
Antidepressant Response of DMT Masked With PropofolNCT06927076 · University Hospital, Basel, Switzerland	Recruiting	Not applicable	1
Ayahuasca, Esketamine and Body Image PerceptionNCT07317219 · University of Sao Paulo	Recruiting	Not applicable	1
Ayahuasca, Esketamine and Premenstrual SymptomsNCT07317232 · University of Sao Paulo	Recruiting	Not applicable	1
Tecfidera and the Gut MicrobiotaNCT02471560 · Biogen	Completed	Phase 4	7
A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants With Generalized Anxiety Disorder (GAD)NCT06051721 · Cybin IRL Limited	Completed	Phase 2	6
Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)NCT04772222 · University of Utah	Completed	Phase 2	5
Ayahuasca and Esketamine for Major DepressionNCT07212946 · University of Sao Paulo	Completed	Phase 2	1
Trifecta Research StudyNCT06810765 · Johns Hopkins University	Withdrawn	Phase 2	1
A Trial of GH001 in Patients With Treatment-resistant DepressionNCT05800860 · GH Research Ireland Limited	Completed	Phase 2	11
Efficacy of Sublingual 5-MeO-DMT for Reducing Anxiety and Depression in MCINCT06812221 · Biomind Labs Inc.	Completed	Phase 1 / Phase 2	1
Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant DepressionNCT02914769 · Universidade Federal do Rio Grande do Norte	Completed	Phase 1 / Phase 2	1
Safety, Tolerability, and Efficacy of Sublingual Microdoses of 5-MeO-DMT for Depression and AnxietyNCT06816667 · Biomind Labs Inc.	Completed	Phase 1 / Phase 2	1
Phase 2 Clinical Trial of GH001 in Postpartum DepressionNCT05804708 · GH Research Ireland Limited	Terminated	Phase 2	4
Phase 2 Clinical Trial of GH001 in Bipolar II DisorderNCT05839509 · GH Research Ireland Limited	Terminated	Phase 2	7
Safety, Tolerability and Antidepressant Effects of DMT in Patients With DepressionNCT06094907 · Universidade Federal do Rio Grande do Norte	Completed	Phase 2	1
SPL026 (DMT Fumarate) in Healthy Subjects and MDD PatientsNCT04673383 · Small Pharma Ltd	Completed	Phase 1 / Phase 2	2
Ayahuasca Assisted Psychotherapy for GriefNCT06150859 · Beckley Med Foundation	Unknown status	Phase 2	1
Clinical Study of GH001 in DepressionNCT04698603 · GH Research Ireland Limited	Completed	Phase 1 / Phase 2	1
Neural Effects of Intravenous N,N-dimethyltryptamine (DMT)NCT07693257 · Jon Dean	Not yet recruiting	Phase 1	1
Pharmacokinetics and Safety of GH001 Delivered Via a GH001 Aerosol Delivery System in Healthy SubjectsNCT07540494 · GH Research Ireland Limited	Not yet recruiting	Phase 1	1
Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy ParticipantsNCT06180759 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Fixed Order, Open-Label, Dose-Escalation Study of DMT in HumansNCT04711915 · Yale University	Active, not recruiting	Phase 1	1
Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)NCT05695495 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Molecular Imaging Study of Harmine/DMT: a Basic Research ApproachNCT06252506 · Insel Gruppe AG, University Hospital Bern	Completed	Phase 1	2
Single and Repeat Doses of DMT in Healthy SubjectsNCT05559931 · Algernon Pharmaceuticals	Active, not recruiting	Phase 1	1
SPL026 With or Without SSRIs in Participants With MDDNCT05553691 · Small Pharma Ltd	Completed	Phase 1	2
Acute Dose-dependent Effects of DMT in Healthy SubjectsNCT05384678 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
IM and IV SPL026 Drug Product in Healthy ParticipantsNCT05644093 · Small Pharma Ltd	Completed	Phase 1	1
Single Ascending Dose Study With BPL-003 in Healthy SubjectsNCT05347849 · Beckley Psytech Limited	Completed	Phase 1	1
Safety and Pharmacokinetics of GH002 in Healthy VolunteersNCT05753956 · GH Research Ireland Limited	Completed	Phase 1	1
Pharmacokinetics, Safety, and Tolerability of Intramuscular 5-MeO-DMT in Healthy VolunteersNCT05698095 · Usona Institute	Completed	Phase 1	1
Dose-finding Study for the Combination of DMT and Harmine in Healthy SubjectsNCT05829603 · Reconnect Labs	Completed	Phase 1	1
Safety and Tolerability of DMT in Healthy AdultsNCT05901012 · Universidade Federal do Rio Grande do Norte	Completed	Phase 1	1
Safety of GH001 in Healthy VolunteersNCT04640831 · GH Research Ireland Limited	Completed	Phase 1	1
Open-Label Dose-Ranging Study of Oral SM-001 in Healthy AdultsNCT05894902 · Advanced Integrative Medical Science Institute	Unknown status	Phase 1	1
Clinical Study of DMT in Healthy AdultsNCT05573568 · Biomind Labs Inc.	Completed	Phase 1	1
Effects of Dimethyltryptamine in Healthy SubjectsNCT04353024 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Single Ascending Dose Study With 5-MeO-DMT in Healthy SubjectsNCT05032833 · Beckley Psytech Limited	Completed	Phase 1	1
Pharmacokinetics of GH001 in Healthy VolunteersNCT05163691 · GH Research Ireland Limited	Completed	Phase 1	1
Mindfulness and PsychedelicsNCT05780216 · Milan Scheidegger	Completed	Early Phase 1	1
Neurodynamics of Prosocial Emotional Processing Following Serotonergic Stimulation With N,N-Dimethyltryptamine (DMT) and Harmine in Healthy SubjectsNCT04716335 · Psychiatric University Hospital, Zurich	Completed	Early Phase 1	1
Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial DystrophyNCT03275896 · Singapore National Eye Centre	Unknown status	Early Phase 1	1
Trifecta Research StudyNCT07717866 · Axial Therapeutic Research	Active, not recruiting	N/A	1
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic PsychedelicsNCT06624137 · Yale University	Terminated	N/A	2
A Innovative Web-based Dance Movement TherapyNCT07474246 · Chin-Tsung Shen	Completed	Not applicable	1
Dance Movement Therapy for Radio-oncological PatientsNCT07001033 · University of Erlangen-Nürnberg Medical School	Completed	Not applicable	1
Cladribine Tablets as an Exit Therapy StrategyNCT06887426 · University Hospital, Strasbourg, France	Not yet recruiting	N/A	1
An Intervention Integrating Physical Therapy Exercise and Dance Movement Therapy for Preventing Falls in Older AdultsNCT05948735 · University of Haifa	Completed	Not applicable	1
Dance/Movement Therapy for Bone Mineral Density in SchizophreniaNCT05716802 · Hebei Province Veterans Hospital	Completed	Not applicable	1
Effect of eHealth on AB Use of Children With Acute, Uncomplicated URTIsNCT06140446 · Max Nieuwdorp	Unknown status	Not applicable	1
Dance and Movement Therapy in Patients With SchizophreniaNCT05500651 · Amasya University	Completed	Not applicable	1
Programme Evaluation on Effectiveness of The Use of Movement-based x 'Elderspirituality - Fu Le Mun Sum' Intervention to Support Elderly People With Depressive SymptomsNCT05308082 · The University of Hong Kong	Completed	Not applicable	1
MIH and Hypersensitivity in ChildrenNCT05705037 · Università degli Studi di Brescia	Unknown status	Not applicable	1
Entheogen ResurgenceNCT05042765 · Vireo Health	Completed	N/A	1
Mindfulness-based Dance/Movement Therapy for Chronic Low Back PainNCT03986489 · Drexel University	Unknown status	Not applicable	1
Delphinus SoftVue™ ROC Reader Study (DMT SV RRS3)NCT04260620 · Delphinus Medical Technologies, Inc.	Completed	N/A	1
Dance Movement Therapy in the Treatment of Depressed Patients: A Randomised Controlled TrialNCT04421651 · University of Jyvaskyla	Completed	Not applicable	—
Effectiveness of Digital Manipulation of Thyroid Cartilage and Fluency Shaping Therapy for the Management of Stuttering in AdultNCT03628755 · Isra University	Completed	Not applicable	1
Dancing for Better Aging: Evaluating the Impact of a Dance/Movement Therapy (D/MT) Program for Older AdultsNCT02455258 · Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal	Completed	Not applicable	1
Unified Cognitive-Behavioral Therapy (CBT) vs. Combined CBT and Dance/Movement Therapy (DMT) for Anxiety DisordersNCT02304796 · Shalvata Mental Health Center	Unknown status	Not applicable	1

Records from ClinicalTrials.gov API v2, data build 2026-08-25. A trial counts for DMT only where the substance is named in its title, summary or interventions. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.