3,4-Methylenedioxymethamphetamine

MDMA

117 registered trials on the federal registry, 8 of them in Phase 3, and 26 recruiting now.

117

Registered trials

Recruiting

In Phase 3

With results posted

Open now

26 recruiting MDMA trials

Trial	Status	Phase	Sites
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use DisorderNCT07118839 · VA Office of Research and Development	Recruiting	Phase 2 / Phase 3	2
MDMA-assisted Massed Prolonged Exposure for PTSDNCT06117306 · Healing Breakthrough	Recruiting	Phase 3	1
Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral InjuryNCT06394284 · Herzog Hospital	Recruiting	Phase 3	1
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress DisorderNCT05790239 · Stephen Robert Marder	Recruiting	Phase 2	2
MDMA-Assisted CBCT for PTSD vs CBCT RCTNCT06044675 · Remedy	Recruiting	Phase 2	1
Ecstasy to Alleviate SEvere Chronic Neuropathic Pain TrialNCT07301632 · Unity Health Toronto	Recruiting	Phase 2	1
Tolerability of MDMA in SchizophreniaNCT05770375 · Anya Bershad, MD, PhD	Recruiting	Phase 1 / Phase 2	1
Preliminary Effectiveness of Individual and Group MDMA-assisted Therapy for Israeli Veterans With PTSD and Moral Injury.NCT05732155 · HaEmek Medical Center, Israel	Recruiting	Phase 2	1
MDMA Therapy in Veterans With PTSDNCT07569159 · Sunstone Medical	Recruiting	Phase 2	1
MDMA-Assisted Massed Exposure Therapy for PTSDNCT07288151 · Emory University	Recruiting	Phase 2	1
MDMA-assisted Therapy for Adjustment Disorder (AD) in Dyads of Patients With Cancer and a Concerned Significant OtherNCT05584826 · Sunstone Medical	Recruiting	Phase 2	1
A Phase 2A Trial of DT402 for Autism Spectrum DisorderNCT07303907 · Definium Therapeutics US, Inc.	Recruiting	Phase 2	1
MDMA for Co-occurring PTSD and OUD After ChildbirthNCT05219175 · University of New Mexico	Recruiting	Phase 2	1
Group vs Individual MDMA-Assisted Therapy for PTSD After the October 7, 2023 EventsNCT07469098 · Sheba Medical Center	Recruiting	Phase 2	2
MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)NCT05783817 · Carolyn Rodriguez	Recruiting	Phase 2	1
MDMA in Borderline Personality DisorderNCT06683014 · Yale University	Recruiting	Phase 2	1
MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress DisorderNCT05837845 · Patricia Suppes	Recruiting	Phase 2	1
Dose Optimization of MDMA-Assisted Therapy for PTSDNCT06418178 · Bronx VA Medical Center	Recruiting	Phase 2	1
MDMA for AUD/PTSD ComorbidityNCT05943665 · Carolina L Haass-Koffler	Recruiting	Phase 2	1
MDMA Assisted Therapy for BNNCT07542145 · Icahn School of Medicine at Mount Sinai	Recruiting	Phase 1	1
MDMA-Assisted Therapy for Mental Healthcare ProvidersNCT07102576 · Rachel Yehuda	Recruiting	Phase 1	1
Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy ParticipantsNCT07494214 · University Hospital, Basel, Switzerland	Recruiting	Phase 1	1
Investigation of Psychedelic Effects in Psychoactive SubstancesNCT06772753 · Johns Hopkins University	Recruiting	Phase 1	1
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)NCT06989957 · Johns Hopkins University	Recruiting	Phase 1	1
MDMA-assisted Therapy for FibromyalgiaNCT06066853 · Spaulding Rehabilitation Hospital	Recruiting	Early Phase 1	1
Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy ControlsNCT06789705 · University Hospital, Basel, Switzerland	Recruiting	Not applicable	1

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All 117 MDMA trials

Trial	Status	Phase	Sites
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use DisorderNCT07118839 · VA Office of Research and Development	Recruiting	Phase 2 / Phase 3	2
MDMA-assisted Massed Prolonged Exposure for PTSDNCT06117306 · Healing Breakthrough	Recruiting	Phase 3	1
Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral InjuryNCT06394284 · Herzog Hospital	Recruiting	Phase 3	1
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress DisorderNCT05790239 · Stephen Robert Marder	Recruiting	Phase 2	2
MDMA-Assisted CBCT for PTSD vs CBCT RCTNCT06044675 · Remedy	Recruiting	Phase 2	1
Ecstasy to Alleviate SEvere Chronic Neuropathic Pain TrialNCT07301632 · Unity Health Toronto	Recruiting	Phase 2	1
Tolerability of MDMA in SchizophreniaNCT05770375 · Anya Bershad, MD, PhD	Recruiting	Phase 1 / Phase 2	1
Preliminary Effectiveness of Individual and Group MDMA-assisted Therapy for Israeli Veterans With PTSD and Moral Injury.NCT05732155 · HaEmek Medical Center, Israel	Recruiting	Phase 2	1
MDMA Therapy in Veterans With PTSDNCT07569159 · Sunstone Medical	Recruiting	Phase 2	1
MDMA-Assisted Massed Exposure Therapy for PTSDNCT07288151 · Emory University	Recruiting	Phase 2	1
MDMA-assisted Therapy for Adjustment Disorder (AD) in Dyads of Patients With Cancer and a Concerned Significant OtherNCT05584826 · Sunstone Medical	Recruiting	Phase 2	1
A Phase 2A Trial of DT402 for Autism Spectrum DisorderNCT07303907 · Definium Therapeutics US, Inc.	Recruiting	Phase 2	1
MDMA for Co-occurring PTSD and OUD After ChildbirthNCT05219175 · University of New Mexico	Recruiting	Phase 2	1
Group vs Individual MDMA-Assisted Therapy for PTSD After the October 7, 2023 EventsNCT07469098 · Sheba Medical Center	Recruiting	Phase 2	2
MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)NCT05783817 · Carolyn Rodriguez	Recruiting	Phase 2	1
MDMA in Borderline Personality DisorderNCT06683014 · Yale University	Recruiting	Phase 2	1
MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress DisorderNCT05837845 · Patricia Suppes	Recruiting	Phase 2	1
Dose Optimization of MDMA-Assisted Therapy for PTSDNCT06418178 · Bronx VA Medical Center	Recruiting	Phase 2	1
MDMA for AUD/PTSD ComorbidityNCT05943665 · Carolina L Haass-Koffler	Recruiting	Phase 2	1
MDMA Assisted Therapy for BNNCT07542145 · Icahn School of Medicine at Mount Sinai	Recruiting	Phase 1	1
MDMA-Assisted Therapy for Mental Healthcare ProvidersNCT07102576 · Rachel Yehuda	Recruiting	Phase 1	1
Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy ParticipantsNCT07494214 · University Hospital, Basel, Switzerland	Recruiting	Phase 1	1
Investigation of Psychedelic Effects in Psychoactive SubstancesNCT06772753 · Johns Hopkins University	Recruiting	Phase 1	1
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)NCT06989957 · Johns Hopkins University	Recruiting	Phase 1	1
MDMA-assisted Therapy for FibromyalgiaNCT06066853 · Spaulding Rehabilitation Hospital	Recruiting	Early Phase 1	1
Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy ControlsNCT06789705 · University Hospital, Basel, Switzerland	Recruiting	Not applicable	1
Epigenetics and MDMA-Assisted Psychotherapy for PTSDNCT06189027 · University of Southern California	Completed	Phase 3	1
MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSDNCT05979844 · Dr. Leslie Morland	Completed	Phase 3	1
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)NCT03537014 · Resilient Pharmaceuticals	Completed	Phase 3	15
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)NCT04077437 · Resilient Pharmaceuticals	Completed	Phase 3	14
A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSDNCT04714359 · Resilient Pharmaceuticals	Completed	Phase 3	15
MDMA-AT for PTSD in Young Adults With Childhood TraumaNCT07765693 · Jenna M. Traynor	Not yet recruiting	Phase 2	1
Clinical Trial of MDMA-Assisted Therapy for Military Service Members With Posttraumatic Stress DisorderNCT07704762 · U.S. Army Medical Research and Development Command	Not yet recruiting	Phase 2	—
MDMA Plus Exposure Therapy for PTSDNCT05746572 · Emory University	Enrolling by invitation	Phase 2	1
MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers and First RespondersNCT05455996 · Nautilus Sanctuary	Not yet recruiting	Phase 2	3
Social Anxiety MDMA-Assisted Therapy InvestigationNCT05138068 · Jason B Luoma	Completed	Phase 2	1
High-Intensity Inpatient MDMA-Assisted Psychotherapy for PTSDNCT06954025 · ARQ National Psychotrauma Centre	Enrolling by invitation	Phase 2	1
MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSDNCT04264026 · VA Loma Linda Health Care System	Completed	Phase 2	1
Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSDNCT04784143 · Resilient Pharmaceuticals	Terminated	Phase 2	1
Group MDMA-therapy for Veterans With PTSDNCT05961527 · Portland VA Research Foundation, Inc	Completed	Phase 1 / Phase 2	1
Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada)NCT03485287 · Resilient Pharmaceuticals	Completed	Phase 2	2
MDMA-Assisted Psychotherapy in People With Posttraumatic Stress DisorderNCT00090064 · Resilient Pharmaceuticals	Completed	Phase 2	1
Randomized, Double-blind, Placebo-Controlled Pilot Study of MDMA-assisted Therapy for PTSDNCT01689740 · Resilient Pharmaceuticals	Completed	Phase 2	1
Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - IsraelNCT00402298 · Resilient Pharmaceuticals	Terminated	Phase 2	1
Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress DisorderNCT01211405 · Resilient Pharmaceuticals	Completed	Phase 2	1
Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSDNCT01793610 · Resilient Pharmaceuticals	Completed	Phase 2	1
Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSDNCT01958593 · Resilient Pharmaceuticals	Terminated	Phase 2	1
Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic AdultsNCT02008396 · Resilient Pharmaceuticals	Completed	Phase 2	1
MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening IllnessNCT02427568 · Resilient Pharmaceuticals	Completed	Phase 2	1
Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSDNCT03282123 · Resilient Pharmaceuticals	Completed	Phase 2	12
MDMA-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic PTSDNCT02876172 · Resilient Pharmaceuticals	Completed	Phase 1 / Phase 2	1
MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in AdolescentsNCT06353282 · University of California, Los Angeles	Withdrawn	Phase 2	1
Open Label Study of MDMA-assisted Psychotherapy for Treatment of PTSD With Optional fMRI Sub-StudyNCT04030169 · MAPS Europe B.V.	Completed	Phase 2	6
A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD)NCT05067244 · Remedy	Completed	Phase 2	1
Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSDNCT04968938 · Resilient Pharmaceuticals	Withdrawn	Phase 2	—
A Multi-Site Study of MDMA-Assisted Psychotherapy for Eating DisordersNCT04454684 · Resilient Pharmaceuticals	Withdrawn	Phase 2	—
Study of Feasibility and Safety of MDMA-Assisted Group Therapy for the Treatment of PTSD in VeteransNCT05173831 · Resilient Pharmaceuticals	Withdrawn	Phase 2	—
Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress DisorderNCT00353938 · Resilient Pharmaceuticals	Completed	Phase 2	1
Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy TrialNCT01458327 · Resilient Pharmaceuticals	Completed	Phase 2	1
MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress DisorderNCT05709353 · University of Sydney	Unknown status	Phase 2	2
MDMA-assisted Therapy in People With Anxiety Related to Advanced Stage CancerNCT00252174 · Brigham and Women's Hospital	Terminated	Phase 2	1
Study of Midomafetamine in Healthy AdultsNCT07584720 · Resilient Pharmaceuticals	Active, not recruiting	Phase 1	1
Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy SubjectsNCT06884514 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD.NCT03752918 · Yale University	Withdrawn	Phase 1	1
Comparative Acute Effects of R-MDMA and S-MDMA in Healthy ParticipantsNCT06905652 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy HumansNCT06081179 · University of Zurich	Completed	Phase 1	1
Acute Effects of 3,4-methylenedioxymethamphetamine (MDMA) With and Without a Booster DoseNCT05809271 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy SubjectsNCT05523401 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Evaluation of MDMA on Startle ResponseNCT03181763 · Resilient Pharmaceuticals	Completed	Phase 1	1
Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy VolunteersNCT01404754 · Resilient Pharmaceuticals	Completed	Phase 1	3
Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-2)NCT04073433 · Resilient Pharmaceuticals	Withdrawn	Phase 1	—
MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic FunctionNCT03606538 · Resilient Pharmaceuticals	Not yet recruiting	Phase 1	1
Food Effects on Bioavailability of MDMA in Healthy VolunteersNCT05147402 · Resilient Pharmaceuticals	Completed	Phase 1	1
Effects of MDMA-like Substances in Healthy SubjectsNCT04847206 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Acute Effects of R- and S-MDMA in Healthy SubjectsNCT05277636 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Effect of Stimulant Drugs on Social PerceptionNCT03790618 · University of Chicago	Completed	Phase 1	1
Effects of MDMA Co-administration on the Response to LSD in Healthy SubjectsNCT04516902 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Abuse Potential and Human Pharmacology of MethyloneNCT05488171 · Germans Trias i Pujol Hospital	Unknown status	Phase 1	1
Neurobiology and Pharmacokinets of Acute MDMA AdministrationNCT01148342 · National Institute on Drug Abuse (NIDA)	Completed	Phase 1	1
Bristol Imperial MDMA in Alcoholism StudyNCT04158778 · Imperial College London	Unknown status	Phase 1	1
Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA)NCT01386177 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Emotional Effects of Methylphenidate and MDMA in Healthy SubjectsNCT01465685 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Influence of Bupropion on the Effects of MDMANCT01771874 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Abuse Liability and Human Pharmacology of MephedroneNCT02232789 · Parc de Salut Mar	Completed	Phase 1	1
Interaction Between Reboxetine and 3,4-Methylenedioxymethamphetamine: Pharmacodynamics (PD) and Pharmacokinetics (PK)NCT00886886 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)NCT00990067 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA)NCT01136278 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
-Methylenedioxymethamphetamine (MDMA, Ecstasy) Induced Changes in Drug Metabolism: Gender and Genetic PolymorphismsNCT01447472 · Parc de Salut Mar	Completed	Phase 1	1
Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)NCT00895804 · University Hospital, Basel, Switzerland	Completed	Phase 1	1
MDMA-Assisted Therapy for Pathological NarcissismNCT06565494 · University of Washington	Active, not recruiting	Early Phase 1	1
Effects of Drugs on Responses to Brain and Emotional ProcessesNCT04053036 · University of Chicago	Completed	Early Phase 1	1
Prosocial Effects of MDMANCT05948683 · University of Chicago	Completed	Early Phase 1	1
Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social FunctionNCT05379959 · University of Chicago	Completed	Early Phase 1	1
Drug Effects on Interpersonal InteractionNCT05123716 · University of Chicago	Completed	Early Phase 1	1
Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear ExtinctionNCT03527316 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Effects of MDMA and Methylphenidate on Social CognitionNCT01616407 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Role of Dopamine, Serotonin and 5-HT2A Receptors in Emotion ProcessingNCT03019822 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Effects of Methylphenidate, Modafinil, and MDMA on Emotion-processing in Humans: A Pharmaco-fMRI StudyNCT01951508 · University Hospital, Basel, Switzerland	Completed	Early Phase 1	1
Circulating Oxytocin Changes in Response to MDMA vs. Placebo in Adult Patients With Autism Spectrum Disorder and Matched Healthy ControlsNCT07555132 · University Hospital, Basel, Switzerland	Not yet recruiting	Not applicable	1
Stanford Regulating Circuits of the Brain Study - MDMANCT04060108 · Stanford University	Completed	N/A	1
The Role of Personal Experience for the Therapeutic Attitude in the Context of Substance-assisted Therapy TrainingNCT05570708 · Felix Mueller	Enrolling by invitation	Not applicable	1
Exploring Mechanisms of Action in MDMA-assisted Psychotherapy for PTSDNCT02102802 · Resilient Pharmaceuticals	Completed	N/A	1
Correlates of Anxiety Associated With a Life-threatening IllnessNCT02954562 · Resilient Pharmaceuticals	Completed	N/A	1
A Multi-site Expanded Access Program for MDMA-assisted Psychotherapy for Patients With Treatment-resistant PTSDNCT04438512 · Resilient Pharmaceuticals	No longer available	N/A	2
Long-Term Safety and Effectiveness of MDMA-Assisted Therapy for PTSDNCT05066282 · Resilient Pharmaceuticals	Completed	N/A	4
Perceptions of MDMA-Assisted Therapy Among Veterans With PTSDNCT05895318 · Albany Research Institute, Inc.	Completed	N/A	1
Sustaining Remission From PTSD Using Tuned Vibroacoustic Stimulation (TVS) Following MDMA-Assisted PsychotherapyNCT05274230 · Apollo Neuroscience, Inc.	Unknown status	Not applicable	1
Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy ControlsNCT04648137 · University Hospital, Basel, Switzerland	Completed	Not applicable	1
Pharmacological Interaction Between Carvedilol and Methylenedioxymethamphetamine (MDMA)NCT01270672 · University Hospital, Basel, Switzerland	Completed	Not applicable	1
Effects of MDMA on Emotional and Social MemoriesNCT03050541 · University of Chicago	Completed	Not applicable	—
Effects of MDMA on Social and Emotional ProcessingNCT01849419 · University of Chicago	Completed	Not applicable	1
Role of Serotonin in Acute and Subacute MDMA EffectsNCT00838305 · California Pacific Medical Center Research Institute	Completed	Not applicable	1
Study of the Effects of MDMA/Ecstasy on Water Regulation, Sleep, and Cognition.NCT01053403 · California Pacific Medical Center Research Institute	Completed	Not applicable	1
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET ImagingNCT01296802 · University of Zurich	Completed	Not applicable	1
Naturalistic Study Into the Hangover Effects of MDMANCT01400204 · Utrecht Institute for Pharmaceutical Sciences	Completed	N/A	1
Functional Brain Imaging in Recreational Users of EcstasyNCT00254306 · Hadassah Medical Organization	Completed	N/A	1
The NeXT Study; The Netherlands XTC Toxicity StudyNCT00235768 · UMC Utrecht	Completed	N/A	3

Records from ClinicalTrials.gov API v2, data build 2026-08-25. A trial counts for MDMA only where the substance is named in its title, summary or interventions. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.