Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults

Inclusion Criteria: * Healthy adults: men and women ages 25-65 years of age * Previous experience with a psychedelic drug * Vital Signs within normal limits for temperature (oral), respiratory rate, heart rate * Normal blood pressure (for age) in the absence of antihypertensive drugs * Normal complete blood count and differential, platelets, coagulation ((PT/PTT) * Liver function tests ≤ 1.5X upper limits of normal * Renal function (BUN, serum Creatinine) - within normal limits * Able to understand and willing to comply with Study Protocol requirements. * Willing to abstain from alcohol for at least 72 hours prior to and following Study Day 0 * No use of recreational drugs for at least 14 days prior to Study Day 0. * Women who are not pregnant or lactating. Exclusion Criteria (None can apply): * Body Mass Index \> 30 or \< 20 * Systemic condition that includes, but is not limited to: hematological, immunological, hepatic, renal, cardiac, neurological conditions that is under current treatment or causes abnormal physical or laboratory parameters. * History of seizures * History of drug or alcohol abuse * History of psychiatric disorder or history of significant trauma, as defined by DSM- V. * Use of SSRIs, MAO inhibitors, or other psychoactive compounds either pharmaceutical drugs or botanical in origin (i.e., 5-HTP, St John's Wort) * Any condition which, in the opinion of the Investigators, would preclude the use of the test article or the successful completion of the study.